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Conserved domains on  [gi|242556202|pdb|2WFR|A]
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Chain A, Desert Hedgehog Protein N-product

Protein Classification

HH_signal and Hint domain-containing protein( domain architecture ID 10471241)

HH_signal and Hint domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HH_signal pfam01085
Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. ...
 2-147 2.30e-109

Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.


:

Pssm-ID: 460055  Cd Length: 161  Bit Score: 308.15  E-value: 2.30e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WFR_A          2 LVPLLYKQFVPGVPERTLGASGPAEGRVARGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWP 81
Cdd:pfam01085  16 LTPLVYKQHVPNVSENTLGASGPSEGKITRNSPRFKELVPNYNPDIIFRDEEGTGADRLMTKRCKDKLNILAILVMNQWP 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
2WFR_A         82 GVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVS 147
Cdd:pfam01085  96 GVKLRVTEAWDEDGHHPPDSLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESRAHIHCS 161
 
Name Accession Description Interval E-value
HH_signal pfam01085
Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. ...
 2-147 2.30e-109

Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.


Pssm-ID: 460055  Cd Length: 161  Bit Score: 308.15  E-value: 2.30e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WFR_A          2 LVPLLYKQFVPGVPERTLGASGPAEGRVARGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWP 81
Cdd:pfam01085  16 LTPLVYKQHVPNVSENTLGASGPSEGKITRNSPRFKELVPNYNPDIIFRDEEGTGADRLMTKRCKDKLNILAILVMNQWP 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
2WFR_A         82 GVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVS 147
Cdd:pfam01085  96 GVKLRVTEAWDEDGHHPPDSLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESRAHIHCS 161
YcbK COG3108
Uncharacterized conserved protein YcbK, DUF882 family [Function unknown];
98-148 1.10e-04

Uncharacterized conserved protein YcbK, DUF882 family [Function unknown];


Pssm-ID: 442342  Cd Length: 138  Bit Score: 39.90  E-value: 1.10e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
2WFR_A       98 AQDSLHYEGRALDITTSDRDRNKyglLARLAVEAGFDWV-YYESRNHVHVSV 148
Cdd:COG3108  82 AKNSLHMLGKAADIRIPGVSLSQ---LRRAALALGRGGVgYYPRSGFVHVDT 130
 
Name Accession Description Interval E-value
HH_signal pfam01085
Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. ...
 2-147 2.30e-109

Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.


Pssm-ID: 460055  Cd Length: 161  Bit Score: 308.15  E-value: 2.30e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WFR_A          2 LVPLLYKQFVPGVPERTLGASGPAEGRVARGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWP 81
Cdd:pfam01085  16 LTPLVYKQHVPNVSENTLGASGPSEGKITRNSPRFKELVPNYNPDIIFRDEEGTGADRLMTKRCKDKLNILAILVMNQWP 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
2WFR_A         82 GVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVS 147
Cdd:pfam01085  96 GVKLRVTEAWDEDGHHPPDSLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESRAHIHCS 161
YcbK COG3108
Uncharacterized conserved protein YcbK, DUF882 family [Function unknown];
98-148 1.10e-04

Uncharacterized conserved protein YcbK, DUF882 family [Function unknown];


Pssm-ID: 442342  Cd Length: 138  Bit Score: 39.90  E-value: 1.10e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
2WFR_A       98 AQDSLHYEGRALDITTSDRDRNKyglLARLAVEAGFDWV-YYESRNHVHVSV 148
Cdd:COG3108  82 AKNSLHMLGKAADIRIPGVSLSQ---LRRAALALGRGGVgYYPRSGFVHVDT 130
Peptidase_M15_3 pfam08291
Peptidase M15;
98-147 1.50e-03

Peptidase M15;


Pssm-ID: 429903  Cd Length: 109  Bit Score: 36.56  E-value: 1.50e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
2WFR_A         98 AQDSLHYEGRALDITTSDRDRNKyglLARLAVEAGFDWV-YYESRNHVHVS 147
Cdd:pfam08291  62 ASQSQHLTGLAADITVGGVNFEE---LAQILRNAGPTGVgIYRHNRFVHVD 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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