|
Name |
Accession |
Description |
Interval |
E-value |
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
1-341 |
0e+00 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 583.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 1 MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEV 80
Cdd:PRK01216 1 MIILFVDFDYFFAQVEEVLNPSLKGKPVVVCVYSGRFEDSGAVATANYEARKLGIKAGMPIVEAKKILPNAVYLPMRKEV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 81 YQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKP 160
Cdd:PRK01216 81 YQQVSNRIMKLLREYSEKIEIASIDEAYLDISDKVKNYQDAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 161 NGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTR 240
Cdd:PRK01216 161 NGIKVIDDEEVKRFINELDIADIPGIGDITAEKLKKLGVNKLVDTLRIEFDELKGIIGEAKAKYLFSLARNEYNEPVRAR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 241 VRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKrIPKAIHVVAVTEDLDIVSRGRTFPHGISKETAYSESVKLLQ 320
Cdd:PRK01216 241 VRKSIGRYVTLPRNTRDLEEIKPYLKRAIEEAYYKLDG-IPKAIHVVAIMEDLDIVSRGRTFTHGISKETAYREAVRLLQ 319
|
330 340
....*....|....*....|.
2RDI_A 321 KILEEDERKIRRIGVRFSKFI 341
Cdd:PRK01216 320 KILEEDERKIRRIGVRFSKII 340
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
4-340 |
2.40e-125 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 362.61 E-value: 2.40e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 4 LFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRfedsGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQ 83
Cdd:cd03586 1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSDR----GVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYRE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 84 VSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGI 163
Cdd:cd03586 77 VSRQIMEILREYTPLVEPLSIDEAYLDVTDYVRLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 164 KVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGmIGEAKAKYLISLARDEYNEPIRT-RVR 242
Cdd:cd03586 157 TVIPPEDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKK-LFGKSGRRLYELARGIDNRPVEPdRER 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 243 KSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDK--RIPKAIHVVAVTEDLDIVSRGRTFPHGI-SKETAYSESVKLL 319
Cdd:cd03586 236 KSIGVERTFSEDLTDPEELLEELLELAEELAERLRKrgLKGRTVTVKLKYADFSTRTRSRTLPEPTdDAEDIYELALELL 315
|
330 340
....*....|....*....|.
2RDI_A 320 QKILeeDERKIRRIGVRFSKF 340
Cdd:cd03586 316 EELL--DGRPIRLLGVRLSGL 334
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
4-338 |
1.76e-122 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 355.90 E-value: 1.76e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 4 LFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGrfeDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQ 83
Cdd:cd00424 1 LHIDFDNFFASVEQLARPELKGRPVVVVPFNS---DSTCVIACSYEARKYGVKRGMPVREARKMCPNLILVPARLDLYRR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 84 VSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEK-ITVTVGISKNKVFAKIAADMAKPNG 162
Cdd:cd00424 78 LSERLLSELEEVAPLVEVASIDELFLDLTGSARLLGLGSEVALRIKRHIAEQLGgITASIGIASNKLLAKLAAKYAKPDG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 163 IKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPI-RTRV 241
Cdd:cd00424 158 LTILDPEDLPGFLSKLPLTDLPGIGAVTAKRLEAVGINPIGDLLAASPDALLALWGGVSGERLWYALRGIDDEPLsPPRP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 242 RKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDK--RIPKAIHVVAVTED------LDIVSRGRTFPHGISKETAYS 313
Cdd:cd00424 238 RKSFSHERVLPRDSRNAEDARPLLRLLLEKLARRLRRdgRGATRLRLWLRTVDgrwsghADIPSRSAPRPISTEDGELLH 317
|
330 340
....*....|....*....|....*.
2RDI_A 314 ESVKLLQKILE-EDERKIRRIGVRFS 338
Cdd:cd00424 318 ALDKLWRALLDdKGPRRLRRLGVRLS 343
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
1-338 |
8.50e-104 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 307.84 E-value: 8.50e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 1 MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRfedsGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEV 80
Cdd:COG0389 1 RRILHVDMDAFYASVEQRDRPELRGKPVAVGGDNNR----GVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFEL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 81 YQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKP 160
Cdd:COG0389 77 YRDVSRRVMAILERYTPLVEPLSIDEAFLDVTGSARLFGSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 161 NGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAkAKYLISLARDEYNEPIRT- 239
Cdd:COG0389 157 DGLTVIPPGEVAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKV-GERLYRLARGIDPRPVEPr 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 240 RVRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKR--IPKAIHVVAVTEDLDIVSRGRTFPHGI-SKETAYSESV 316
Cdd:COG0389 236 RPRKSIGVERTFGEDLTDLEELEAALRRLAERLAERLRRQglGARTVTVKLRTSDFRTTTRSRTLPEPTdDTAELLRAAR 315
|
330 340
....*....|....*....|..
2RDI_A 317 KLLQKILEEdERKIRRIGVRFS 338
Cdd:COG0389 316 ELLERIYRP-GRPVRLLGVRLS 336
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
9-335 |
4.91e-70 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 221.92 E-value: 4.91e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 9 DYFYAQVEEVLNPSLKGKPVVVcvfSGRFEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRI 88
Cdd:PRK02406 2 DCFYAAVEMRDNPELRGKPVAV---GGSPGRRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 89 MNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDD 168
Cdd:PRK02406 79 REIFRRYTDLIEPLSLDEAYLDVTDNKLCIGSATLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVITP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 169 EEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLK---GMIGEakakYLISLARDEYNEPIRT-RVRKS 244
Cdd:PRK02406 159 EEVDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIrhfGKFGR----RLYERARGIDERPVKPdRERKS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 245 IGRIVTMKRNSRNLEEIKpylfRAIEESYYKLDKRIPKA-----IHVVAV---TEDLDIVSRGRTfPHGISKETAYsesv 316
Cdd:PRK02406 235 VGVERTFAEDLYDLEACL----AELPRLAEKLERRLERAkpdkrIKTVGVklkFADFQQTTKEHT-ADPLDKADLI---- 305
|
330 340
....*....|....*....|.
2RDI_A 317 KLLQKILEE--DERKIRRIGV 335
Cdd:PRK02406 306 ELLAQALLRrlGGRGVRLLGV 326
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
2-340 |
5.39e-65 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 209.19 E-value: 5.39e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 2 IVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRfedsGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVY 81
Cdd:PRK14133 4 VIIHVDMDAFFASVEQMDNPKLKGKPVIVGGISER----GVVSTCSYEARKYGVHSAMPVFMAKKRCPHGIFLPVRHERY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 82 QQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDyreAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPN 161
Cdd:PRK14133 80 KEVSKNIFKILYEVTPIVEPVSIDEAYLDITNIKEE---PIKIAKYIKKKVKKETGLTLSVGISYNKFLAKLASDWNKPD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 162 GIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRV 241
Cdd:PRK14133 157 GIKIITEDMIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKLSREFLIEYFGKFGVEIYERIRGIDYREVEVSRE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 242 RKSIGRIVTMKRNSRNLEEIKPYLFR---AIEESYYKldKRI-PKAIHVVAVTEDLDIVSRGRTFPHGI-SKETAYSESV 316
Cdd:PRK14133 237 RKSIGKETTLKKDTKDKEELKKYLKDfsnIISEELKK--RNLyGKTVTVKIKTSDFQTHTKSKTLNDYIrDKEEIYNVAC 314
|
330 340
....*....|....*....|....
2RDI_A 317 KLLQKIleEDERKIRRIGVRFSKF 340
Cdd:PRK14133 315 EILEHI--NIKEPIRLIGLSVSNL 336
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
6-156 |
4.65e-56 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 179.31 E-value: 4.65e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 6 VDFDYFYAQVEEVLNPSLKGKPVVVcvfsGRFEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVS 85
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAV----GGGNGRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRAS 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
2RDI_A 86 SRIMNLLREY-SEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAAD 156
Cdd:pfam00817 77 RKIFEILRRFsTPKVEQASIDEAFLDLTGLEKLFGAEEALAKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
3-338 |
1.05e-53 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 182.83 E-value: 1.05e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 3 VLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRfedsGAVATANYEARKFGVKAGIPIVEAKKILPN-AVYLPMRKEVY 81
Cdd:PRK03348 7 VLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGGR----GVVAGASYEARVFGARSAMPMHQARRLVGNgAVVLPPRFVVY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 82 QQVSSRIMNLLREYSEKIEIASIDEAYLDIS-------DKVRDYREaynlglEIKNKILEKEKITVTVGISKNKVFAKIA 154
Cdd:PRK03348 83 RAASRRVFDTLRELSPVVEQLSFDEAFVEPAelagasaEEVEAFAE------RLRARVREETGLPASVGAGSGKQIAKIA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 155 ADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYN 234
Cdd:PRK03348 157 SGLAKPDGIRVVPPGEERELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAALSEAEVANLLGATVGPALHRLARGIDD 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 235 EPIRTRVR-KSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKL--DKRIPKAIHVVAVTEDLDIVSRGRTFPHG-ISKET 310
Cdd:PRK03348 237 RPVAERAEaKQISAESTFAVDLTTRAQLREAIERIAEHAHRRLlkDGRGARTVTVKLRKSDFSTLTRSATLPYAtDDAAV 316
|
330 340
....*....|....*....|....*....
2RDI_A 311 AYSESVKLLqkiLEEDER-KIRRIGVRFS 338
Cdd:PRK03348 317 LAATARRLL---LDPDEIgPIRLVGVGFS 342
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
2-335 |
1.25e-53 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 181.38 E-value: 1.25e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 2 IVLFVDFDYFYAQVEEVLNPSLKGKPVVVcvfSGRFED-SGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEV 80
Cdd:PRK01810 6 VIFHVDMNSFFASVEIAYDPSLQGKPLAV---AGNEKErKGIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRRPNFDR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 81 YQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYReAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKP 160
Cdd:PRK01810 83 YREASRQMFQILSEFTPLVQPVSIDEGYLDITDCYALGS-PLEIAKMIQQRLLTELQLPCSIGIAPNKFLAKMASDMKKP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 161 NGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKyLISLARDEYNEPI--- 237
Cdd:PRK01810 162 LGITVLRKRDVPEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGINGVR-LQRRANGIDDRPVdpe 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 238 RTRVRKSIGRIVTMKRNSRNLEEIKPyLFRAIEESyykLDKRIpKAIHVVAVTEDLDI-------VSRGRTFPHGI-SKE 309
Cdd:PRK01810 241 AIYQFKSVGNSTTLSHDMDEEKELLD-VLRRLSKS---VSKRL-QKKTVVSYNVQIMIryhdrrtITRSKTLKNPIwEKR 315
|
330 340
....*....|....*....|....*.
2RDI_A 310 TAYSESVKLLQKilEEDERKIRRIGV 335
Cdd:PRK01810 316 DIFQAASRLFKQ--HWNGDPVRLLGV 339
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
2-339 |
5.40e-52 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 176.74 E-value: 5.40e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 2 IVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDsgaVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVY 81
Cdd:cd01701 48 IIMHVDFDCFFVSVSIRNRPDLKGKPVAVCHGKGPNSE---IASCNYEARSYGIKNGMWVGQAKKLCPQLVTLPYDFEAY 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 82 QQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREA-YNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKP 160
Cdd:cd01701 125 EEVSLTFYEILASYTDNIEAVSCDEALIDITSLLEETYELpEELAEAIRNEIRETTGCSASVGIGPNILLARLATRKAKP 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 161 NGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTL--SIEFDKLKGMIGEAKAKYLISLARDEYNEPIR 238
Cdd:cd01701 205 DGQYHLSAEKVEEFLSQLKVGDLPGVGSSLAEKLVKLFGDTCGGLElrSKTKEKLQKVLGPKTGEKLYDYCRGIDDRPVT 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 239 T-RVRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLdKRIPKAIHVVAVT------------------EDLDIVSRG 299
Cdd:cd01701 285 GeKERKSVSAEINYGIRFTNVDDVEQFLQRLSEELSKRL-EESNVTGRQITLKlmkrapgapieppkymghGICDSFSKS 363
|
330 340 350 360
....*....|....*....|....*....|....*....|
2RDI_A 300 RTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSK 339
Cdd:cd01701 364 STLGVATDDSGVIGTEAKKLFRDLSIPPEELRGVGIQVTK 403
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
2-339 |
3.74e-48 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 167.10 E-value: 3.74e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 2 IVLFVDFDYFYAQVEEVLNPSLKGKPVVVcvfSGRFED-SGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEV 80
Cdd:PRK03103 4 VILLVDMQSFYASVEKAANPELKGRPVIV---SGDPERrSGVVLAACPLAKAYGVKTAERLWEAQQKCPDLVVVKPRMQR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 81 YQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMA-- 158
Cdd:PRK03103 81 YIDVSLQITRILEDFTDLVEPFSIDEQFLDVTGSQKLFGSPLEIAQKIQQRIMRETGVYARVGIGPNKLLAKMACDNFak 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 159 -KPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLK---GMIGEAkakyLISLARDEYN 234
Cdd:PRK03103 161 kNPDGLFTLDKEDVPADLWPLPVRKLFGVGSRMEKHLRRMGIRTIGQLANTPLERLKkrwGINGEV----LWRTANGIDY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 235 EPIRTRV---RKSIGRIVTMKRNSRNLEEIKPYLFRAIEE--SYYKLDKRIPKAIHVVAVTEDLD---IVSRGRTFPH-- 304
Cdd:PRK03103 237 SPVTPHSldrQKAIGHQMTLPRDYRGFEEIKVVLLELCEEvcRRARAKGYMGRTVSVSLRGADFDwptGFSRQMTLPEpt 316
|
330 340 350
....*....|....*....|....*....|....*
2RDI_A 305 GISKETaYSESVKLLQKILeeDERKIRRIGVRFSK 339
Cdd:PRK03103 317 NLAMEV-YEAACKLFHRHW--DGKPVRRVGVTLSN 348
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
3-336 |
7.58e-46 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 159.42 E-value: 7.58e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 3 VLFVDFDYFYAQVEEVLNPSLKGKPVVVcvfSGR---FEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKE 79
Cdd:PRK03352 7 VLHVDLDQFIAAVELLRRPELAGLPVIV---GGNgdpTEPRKVVTCASYEARAFGVRAGMPLRTAARRCPDAVFLPSDPA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 80 VYQQVSSRIMNLLREYSEKIEIASIDEAYL--DISDKvrdyrEAynLGLEIKNKILEKEKITVTVGISKNKVFAKIAADM 157
Cdd:PRK03352 84 AYDAASEEVMATLRDLGVPVEVWGWDEAFLgvDTDDP-----EA--LAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 158 AKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPI 237
Cdd:PRK03352 157 AKPAGVFRLTDANWMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLAAADPAELAATFGPTTGPWLLLLARGGGDTEV 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 238 RT--RVRKSIGRIVTMKRN----SRNLEEIKPYLFRAIEEsyYKLDKRIPKAIHVVAVTEDLDIVSRGRTFPH-GISKET 310
Cdd:PRK03352 237 SAepWVPRSRSREVTFPQDltdrAEVESAVRELARRVLDE--VVAEGRPVTRVAVKVRTATFYTRTKIRKLPEpTTDPDV 314
|
330 340
....*....|....*....|....*.
2RDI_A 311 AYSESVKLLQKIlEEDeRKIRRIGVR 336
Cdd:PRK03352 315 IEAAALDVLDRF-ELD-RPVRLLGVR 338
|
|
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
4-200 |
1.23e-43 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 153.47 E-value: 1.23e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 4 LFVDFDYFYAQVEEVLNPSLKGKPVVV------CVfsgrfedsgaVAtANYEARKFGVKAGIPIVEAKKILP--NAVYLP 75
Cdd:cd01700 1 ALVDCNSFYASCERVFRPLLLGRPLVVlsnndgCV----------IA-RSPEAKALGIKMGSPYFKVPDLLErhGVAVFS 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 76 MRKEVYQQVSSRIMNLLREYSEKIEIASIDEAYLDISDkVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAA 155
Cdd:cd01700 70 SNYALYGDMSRRIMSILERFSPDVEVYSIDESFLDLTG-SLRFGDLEELARKIRRRILQETGIPVTVGIGPTKTLAKLAN 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
2RDI_A 156 DMAKPN----GIKVIDDEEVKR-LIRELDIADVPGIGNITAEKLKKLGIN 200
Cdd:cd01700 149 DLAKKKnpygGVVDLTDEEVRDkLLKILPVGDVWGIGRRTAKKLNAMGIH 198
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
3-319 |
1.37e-43 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 154.76 E-value: 1.37e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 3 VLFVDFDYFYAQVEEVLNPSLKGKPVVVcvfsgrfeDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQ 82
Cdd:PRK03858 6 ILHADLDSFYASVEQRDDPALRGRPVIV--------GGGVVLAASYEAKAYGVRTAMGGRQARRLCPQAVVVPPRMSAYS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 83 QVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNG 162
Cdd:PRK03858 78 RASKAVFEVFRDTTPLVEGLSIDEAFLDVGGLRRISGTPVQIAARLRRRVREEVGLPITVGVARTKFLAKVASQVAKPDG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 163 IKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVR 242
Cdd:PRK03858 158 LLVVPPDRELAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAELPESALVSLLGPAAGRHLHALAHNRDPRRVETGRR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 243 -KSIGRIVTMKRNSRNLEEIKPYLFRAIEesyyKLDKRIPKAIHVV-AVT-----EDLDIVSRGRTFPHGISKETAYSES 315
Cdd:PRK03858 238 rRSVGAQRALGRGPNSPAEVDAVVVALVD----RVARRMRAAGRTGrTVVlrlrfDDFTRATRSHTLPRPTASTATLLAA 313
|
....
2RDI_A 316 VKLL 319
Cdd:PRK03858 314 ARDL 317
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
6-338 |
4.29e-41 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 148.54 E-value: 4.29e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 6 VDFDYFYAQVEEVLNPSLKGKPVVVCvfSGRfedSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVS 85
Cdd:PRK02794 41 IDCDAFYASVEKRDNPELRDKPVIIG--GGK---RGVVSTACYIARIHGVRSAMPMFKALKLCPDAVVIKPDMEKYVRVG 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 86 SRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKE-KITVTVGISKNKVFAKIAADMAKPNGIK 164
Cdd:PRK02794 116 REVRAMMQALTPLVEPLSIDEAFLDLSGTERLHGAPPAVVLARFARRVEREiGITVSVGLSYNKFLAKIASDLDKPRGFS 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 165 VIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLK---GMIGEAkakyLISLARDEYNEPIRT-R 240
Cdd:PRK02794 196 VIGRAEALAFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRADEADLMrrfGSMGLR----LWRLARGIDDRKVSPdR 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 241 VRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLdKRIPKAIHVVAV---TEDLDIVSRGRTFPHGI-SKETAYSESV 316
Cdd:PRK02794 272 EAKSVSAETTFETDLSDFEDLEPILWRLSEKVSRRL-KAAGLAGRTVTLklkTADFRLRTRRRTLEDPTqLADRIFRTAR 350
|
330 340
....*....|....*....|..
2RDI_A 317 KLLQKilEEDERKIRRIGVRFS 338
Cdd:PRK02794 351 ELLEK--ETDGTAFRLIGIGVS 370
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
6-325 |
8.25e-35 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 130.51 E-value: 8.25e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 6 VDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFedsgAVataNYEARKFGVKAGIPIVEAKKILPN------AVYLPMRK- 78
Cdd:cd01702 3 IDMDAFFAQVEQVRLGLLRNDPVAVVQWNSII----AV---SYAARAFGVTRFMTIDEAKKKCPDlilahvATYKKGEDe 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 79 ----------------EVYQQVSSRIMNLLREYSEKIEIASIDEAYLDIsdkvrdyreAYNLGLEIKNKILEKEKITVTV 142
Cdd:cd01702 76 adyhenpsparhkvslDPYRRASRKILNILKRFGDVVEKASIDEAYLDL---------GSRIVEEIRQQVYDELGYTCSA 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 143 GISKNKVFAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLK-KLGINKLVDTLSIEF--DKLKGMIGE 219
Cdd:cd01702 147 GIAHNKMLAKLASGMNKPNAQTILRNDAVASFLSSLPITSIRGLGGKLGEEIIdLLGLPTEGDVAGFRSseSDLQEHFGE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 220 AKAKYLISLARDEYNEPIRTRVR-KSIGRIVTMKR-NSRNLEEIKPYL--FRA-IEESYYKLDK---RIPKAIhVVAVTE 291
Cdd:cd01702 227 KLGEWLYNLLRGIDHEPVKPRPLpKSMGSSKNFPGkTALSTEDVQHWLlvLASeLNSRLEDDRYennRRPKTL-VLSLRQ 305
|
330 340 350
....*....|....*....|....*....|....*
2RDI_A 292 DLDIVSRGRTFP-HGISKETAYSESVKLLQKILEE 325
Cdd:cd01702 306 RGDGVRRSRSCAlPRYDAQKIVKDAFKLIKAINEE 340
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
4-200 |
8.90e-30 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 117.19 E-value: 8.90e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 4 LFVDFDYFYAQVEEVLNPSLKGKPVVVcvfsgrfEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYL------Pmr 77
Cdd:cd01703 1 IHLDLDCFYAQVEEIRDPSLKSKPLGI-------QQKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVngedltP-- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 78 kevYQQVSSRIMNLLREYS--EKIEIASIDEAYLDISDkVRdYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAA 155
Cdd:cd01703 72 ---FRDMSKKVYRLLRSYSwnDRVERLGFDENFMDVTE-MR-LLVASHIAYEMRERIENELGLTCCAGIASNKLLAKLVG 146
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
2RDI_A 156 DMAKPNGIKVIDDEEVKRLIRELDIAD---VPGIGNITAEKLKKLGIN 200
Cdd:cd01703 147 SVNKPNQQTTLLPPSCADLMDFMDLHDlrkIPGIGYKTAAKLEAHGIS 194
|
|
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
6-204 |
7.52e-28 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 112.55 E-value: 7.52e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 6 VDFDYFYAQVEEVLNPSLKGKPVVVCVfsgrfEDSGAVATANYEARKFGVKAGIPIVEAKKI-LPNAVY-LPMRKEVYQQ 83
Cdd:PRK03609 5 CDVNSFYASCETVFRPDLRGKPVVVLS-----NNDGCVIARSAEAKALGIKMGDPWFKQKDLfRRCGVVcFSSNYELYAD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 84 VSSRIMNLLREYSEKIEIASIDEAYLDISDkVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAK---P 160
Cdd:PRK03609 80 MSNRVMSTLEELSPRVEIYSIDEAFCDLTG-VRNCRDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKkwqR 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
2RDI_A 161 NGIKVIDDEEVKR---LIRELDIADVPGIGNITAEKLKKLGINKLVD 204
Cdd:PRK03609 159 QTGGVVDLSNLERqrkLLSLQPVEEVWGVGRRISKKLNAMGIKTALD 205
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
6-278 |
2.37e-26 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 109.72 E-value: 2.37e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 6 VDFDYFYAQVEEVLNPSLKGKPVVVCVFSgrfedsgAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVS 85
Cdd:PTZ00205 138 LDMDMFYAAVEIKKHPEYAAIPLAIGTMT-------MLQTANYVARGRGIRQGMPGFLALKICPNLLILPPDFDAYNEES 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 86 SRIMNLLREYSEKIEIASIDEAYLDISDKVRDY---REAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNG 162
Cdd:PTZ00205 211 NTVRRIVAEYDPNYISFGLDELTLEVSAYIERFegtKTAEDVASELRVRVFGETKLTASAGIGPTAALAKIASNINKPNG 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 163 ---IKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGI-------NKLVDTLSIEFDK-----LKGMIGEAKAKYLIS 227
Cdd:PTZ00205 291 qhdLNLHTRGDVMTYVRDLGLRSVPGVGKVTEALLKGLGIttlsdiyNRRVELCYILHNNlfrflLGASIGIMQWPDAAT 370
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
2RDI_A 228 LARDEYNEPIRTRVRKSIG--RIVTMKRNSRNLEEIKPYLFraiEESYYKLDK 278
Cdd:PTZ00205 371 AANTENCEGATGGQRKAISseRSFTTPRTKEGLQEMVDTVF---NGAYEEMRK 420
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
4-204 |
4.25e-11 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 63.17 E-value: 4.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 4 LFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRfedsGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQ 83
Cdd:cd03468 1 LALWFPRLPLDALLRNRPADDEAPLAVVERKKA----GRILACNAAARAAGVRPGMPLAEALALCPNLQVVEYDPEADAR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 84 VSSRIMNLLREYSEKIEIASIDEAYLDISdkvrdyREAYNLGLEIKNKI-----LEKEKITVTVGISKNKVFAKIAADMA 158
Cdd:cd03468 77 ALQELALWLLRFTPLVALDGPDGLLLDVT------GCLHLFGGEDALAAslraaLATLGLSARAGIADTPGAAWLLARAG 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
2RDI_A 159 KPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVD 204
Cdd:cd03468 151 GGRGVLRREALAAALVLLAPLPVAALRLPPETVELLARLGLRTLGD 196
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
242-341 |
5.05e-09 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 53.33 E-value: 5.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 242 RKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKL--DKRIPKAIHVVAVTEDLDIVSRGRTFPHGI-SKETAYSESVKL 318
Cdd:pfam11799 1 RKSIGAERTFGRDLTDLEELREALLELAEELAERLrrQGLVARTVTVKIRYSDFRTITRSVTLPSPTdDTDEIYRAALRL 80
|
90 100
....*....|....*....|...
2RDI_A 319 LQKILeeDERKIRRIGVRFSKFI 341
Cdd:pfam11799 81 LRRLY--RGRPVRLLGVSLSNLV 101
|
|
| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
168-199 |
4.33e-06 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 42.77 E-value: 4.33e-06
10 20 30
....*....|....*....|....*....|..
2RDI_A 168 DEEVKRLIRELDIADVPGIGNITAEKLKKLGI 199
Cdd:pfam11798 1 PDDVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
|
|
| radA |
PRK04301 |
DNA repair and recombination protein RadA; Validated |
176-261 |
2.67e-04 |
|
DNA repair and recombination protein RadA; Validated
Pssm-ID: 235273 [Multi-domain] Cd Length: 317 Bit Score: 42.17 E-value: 2.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RDI_A 176 RELDIADVPGIGNITAEKLKKLGINKLVD--TLSIEFDKLKGMIGEAKAKYLISLARD-------EYNEPIRTRvRKSIG 246
Cdd:PRK04301 4 KEKDLEDLPGVGPATAEKLREAGYDTVEAiaVASPKELSEAAGIGESTAAKIIEAAREaadiggfETALEVLER-RKNVG 82
|
90
....*....|....*
2RDI_A 247 RIVTmkrNSRNLEEI 261
Cdd:PRK04301 83 KITT---GSKELDEL 94
|
|
| |
