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Conserved domains on  [gi|146387024|pdb|2OI9|C]
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Chain C, T cell receptor beta chain

Protein Classification

T-cell receptor beta chain V region( domain architecture ID 10147293)

T-cell receptor beta chain V (variable) region participates in the antigen recognition of an alpha-beta T cell antigen-specific receptor essential to the immune response; it is present on the cell surface of T lymphocytes to recognize peptide-major histocompatibility (pMH) complexes displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 4-109 1.28e-50

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


:

Pssm-ID: 409480  Cd Length: 110  Bit Score: 155.90  E-value: 1.28e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OI9_C        4 VTQSPRNKVAVTGEKVTLSCNQTNNHNNMYWYRQDTGHELRLIYYSYGAGSTEKGDIP-DGYKASRPSQENFSLTLESAT 82
Cdd:cd05899   1 VTQSPRYLIKRRGQSVTLRCSQKSGHDNMYWYRQDPGKGLQLLFYSYGGGLNEEGDLPgDRFSASRPSLTRSSLTIKSAE 80

                        90       100       110
                ....*....|....*....|....*....|
2OI9_C       83 PSQTSVYFCAS---GGGGTLYFGAGTRLSV 109
Cdd:cd05899  81 PEDSAVYLCASslgGGADEAYFGPGTRLTV 110
 
Name Accession Description Interval E-value
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 4-109 1.28e-50

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 155.90  E-value: 1.28e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OI9_C        4 VTQSPRNKVAVTGEKVTLSCNQTNNHNNMYWYRQDTGHELRLIYYSYGAGSTEKGDIP-DGYKASRPSQENFSLTLESAT 82
Cdd:cd05899   1 VTQSPRYLIKRRGQSVTLRCSQKSGHDNMYWYRQDPGKGLQLLFYSYGGGLNEEGDLPgDRFSASRPSLTRSSLTIKSAE 80

                        90       100       110
                ....*....|....*....|....*....|
2OI9_C       83 PSQTSVYFCAS---GGGGTLYFGAGTRLSV 109
Cdd:cd05899  81 PEDSAVYLCASslgGGADEAYFGPGTRLTV 110
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 6-110 1.95e-21

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 81.74  E-value: 1.95e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OI9_C          6 QSPRNKVAVTGEKVTLSC----NQTNNHNNMYWYRQDTGHELRLIYYSYGAGSTEKGDiPDGYKASR-PSQENFSLTLES 80
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCtyssSMSEASTSVYWYRQPPGKGPTFLIAYYSNGSEEGVK-KGRFSGRGdPSNGDGSLTIQN 79

                          90       100       110
                  ....*....|....*....|....*....|
2OI9_C         81 ATPSQTSVYFCASGGGGTLYFGAGTRLSVL 110
Cdd:pfam07686  80 LTLSDSGTYTCAVIPSGEGVFGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 8-109 3.04e-10

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 52.51  E-value: 3.04e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OI9_C           8 PRNKVAVTGEKVTLSCNQTNN-HNNMYWYRQDtgheLRLIYYsygagstekgdiPDGYKASRPSQeNFSLTLESATPSQT 86
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSpPPEVTWYKQG----GKLLAE------------SGRFSVSRSGS-TSTLTISNVTPEDS 63

                           90       100
                   ....*....|....*....|...
2OI9_C          87 SVYFCASGGGGTLYFGaGTRLSV 109
Cdd:smart00410  64 GTYTCAATNSSGSASS-GTTLTV 85
 
Name Accession Description Interval E-value
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 4-109 1.28e-50

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 155.90  E-value: 1.28e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OI9_C        4 VTQSPRNKVAVTGEKVTLSCNQTNNHNNMYWYRQDTGHELRLIYYSYGAGSTEKGDIP-DGYKASRPSQENFSLTLESAT 82
Cdd:cd05899   1 VTQSPRYLIKRRGQSVTLRCSQKSGHDNMYWYRQDPGKGLQLLFYSYGGGLNEEGDLPgDRFSASRPSLTRSSLTIKSAE 80

                        90       100       110
                ....*....|....*....|....*....|
2OI9_C       83 PSQTSVYFCAS---GGGGTLYFGAGTRLSV 109
Cdd:cd05899  81 PEDSAVYLCASslgGGADEAYFGPGTRLTV 110
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 4-109 1.12e-35

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 118.21  E-value: 1.12e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OI9_C        4 VTQSPRNKVAVTGEKVTLSCNQTN--NHNNMYWYRQDTGHELRLIYYSYGAGSTEKGDIPDGYKASRPSQENFSLTLESA 81
Cdd:cd00099   1 VTQSPRSLSVQEGESVTLSCEVSSsfSSTYIYWYRQKPGQGPEFLIYLSSSKGKTKGGVPGRFSGSRDGTSSFSLTISNL 80

                        90       100       110
                ....*....|....*....|....*....|.
2OI9_C       82 TPSQTSVYFCA---SGGGGTLYFGAGTRLSV 109
Cdd:cd00099  81 QPEDSGTYYCAvseSGGTDKLTFGSGTRLTV 111
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 6-110 1.95e-21

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 81.74  E-value: 1.95e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OI9_C          6 QSPRNKVAVTGEKVTLSC----NQTNNHNNMYWYRQDTGHELRLIYYSYGAGSTEKGDiPDGYKASR-PSQENFSLTLES 80
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCtyssSMSEASTSVYWYRQPPGKGPTFLIAYYSNGSEEGVK-KGRFSGRGdPSNGDGSLTIQN 79

                          90       100       110
                  ....*....|....*....|....*....|
2OI9_C         81 ATPSQTSVYFCASGGGGTLYFGAGTRLSVL 110
Cdd:pfam07686  80 LTLSDSGTYTCAVIPSGEGVFGKGTRLTVL 109
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 4-109 1.14e-19

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 77.31  E-value: 1.14e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OI9_C        4 VTQSPRNKVAVTGEKVTLSCN-QTNNHNNMYWYRQDTGHELR-LIYYSYGAGSTEKGDIPDGYKASRPSqenFSLTLESA 81
Cdd:cd04983   1 VTQSPQSLSVQEGENVTLNCNySTSTFYYLFWYRQYPGQGPQfLIYISSDSGNKKKGRFSATLDKSRKS---SSLHISAA 77

                        90       100       110
                ....*....|....*....|....*....|.
2OI9_C       82 TPSQTSVYFCA---SGGGGTLYFGAGTRLSV 109
Cdd:cd04983  78 QLSDSAVYFCAlseSGGTGKLTFGKGTRLTV 108
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 4-109 1.09e-14

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 64.72  E-value: 1.09e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OI9_C        4 VTQSPRNKVAVTGEKVTLSC--NQTNNHNNMYWYRQDTGHELRLIYYSygaGSTEKGDIPDGYKASrPSQENFSLTLESA 81
Cdd:cd04980   3 MTQSPASLSVSPGERVTISCkaSQSISSNYLAWYQQKPGQAPKLLIYY---ASTLHSGVPSRFSGS-GSGTDFTLTISSV 78

                        90       100
                ....*....|....*....|....*...
2OI9_C       82 TPSQTSVYFCASGGGGTLYFGAGTRLSV 109
Cdd:cd04980  79 EPEDAAVYYCQQGYTFPYTFGGGTKLEI 106
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 4-109 1.72e-11

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 56.32  E-value: 1.72e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OI9_C        4 VTQSPRNKVAVtGEKVTLSC---NQTNNHNNMYWYRQDTGHELR-LIYYSYGAGStekgDIPDGYKASRpSQENFSLTLE 79
Cdd:cd04984   2 LTQPSSLSVSP-GETVTITCtgsSGNISGNYVNWYQQKPGSAPRyLIYEDKHRPS----GIPDRFSGSK-SGNTASLTIS 75

                        90       100       110
                ....*....|....*....|....*....|
2OI9_C       80 SATPSQTSVYFCASGGGGTLYFGAGTRLSV 109
Cdd:cd04984  76 GAQTEDEADYYCQVWDSNSYVFGGGTKLTV 105
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 4-109 3.85e-11

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 55.83  E-value: 3.85e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OI9_C        4 VTQSPRNKVAVTGEKVTLSCNQTNNHNN---MYWYRQDTGHEL-RLIYYSYGAGSTEKGDIPDG-YKASRPSQE-NFSLT 77
Cdd:cd04982   1 LEQPQLSITREESKSVTISCKVSGIDFSttyIHWYRQKPGQALeRLLYVSSTSAVRKDSGKTKNkFEARKDVGKsTSTLT 80

                        90       100       110
                ....*....|....*....|....*....|....*.
2OI9_C       78 LESATPSQTSVYFCASGGGGTLY----FGAGTRLSV 109
Cdd:cd04982  81 ITNLEKEDSATYYCAYWESGSGYyikvFGSGTKLIV 116
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 8-109 3.04e-10

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 52.51  E-value: 3.04e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OI9_C           8 PRNKVAVTGEKVTLSCNQTNN-HNNMYWYRQDtgheLRLIYYsygagstekgdiPDGYKASRPSQeNFSLTLESATPSQT 86
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSpPPEVTWYKQG----GKLLAE------------SGRFSVSRSGS-TSTLTISNVTPEDS 63

                           90       100
                   ....*....|....*....|...
2OI9_C          87 SVYFCASGGGGTLYFGaGTRLSV 109
Cdd:smart00410  64 GTYTCAATNSSGSASS-GTTLTV 85
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 4-109 2.13e-09

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 50.98  E-value: 2.13e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OI9_C        4 VTQSPRNKVAVTGEKVTLSCNQTNNHNNMY--WYRQDTGHELRLIYYSYgagSTEKGDIPDGYKAS-RPSQENFSLTLES 80
Cdd:cd07706   2 VTQAQPDVSVQVGEEVTLNCRYETSWTNYYlfWYKQLPSGEMTFLIRQD---SSEQNAKSGRYSVNfQKAQKSISLTISA 78

                        90       100       110
                ....*....|....*....|....*....|..
2OI9_C       81 ATPSQTSVYFCASGGGG---TLYFGAGTRLSV 109
Cdd:cd07706  79 LQLEDSAKYFCALSLPYdtdKLIFGKGTRLTV 110
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 6-109 2.59e-09

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409497  Cd Length: 116  Bit Score: 50.91  E-value: 2.59e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OI9_C        6 QSPRNKVAVTGEKVTLSC--NQTNNHNNMYWYRQDTGHELR-----LIYYSYGAGST--EKGDIPDGYKASRPSQENFSL 76
Cdd:cd07700   3 QTPGSLLVQTNQTVKMSCeaKTSPKNTRIYWLRQRQAPSKDshfefLASWDPSKGIVygEGVDQEKLIILSDSDSSRYIL 82

                        90       100       110
                ....*....|....*....|....*....|...
2OI9_C       77 TLESATPSQTSVYFCASGGGGTLYFGAGTRLSV 109
Cdd:cd07700  83 SLMSVKPEDSGTYFCMTVGSPELIFGTGTKLSV 115
IGv smart00406
Immunoglobulin V-Type;
19-92 8.88e-09

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 48.53  E-value: 8.88e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OI9_C          19 VTLSC---NQTNNHNNMYWYRQDTGHELRLIYYSYGAGSTEkgdIPDGYKA-----SRPSQENFSLTLESATPSQTSVYF 90
Cdd:smart00406   2 VTLSCkfsGSTFSSYYVSWVRQPPGKGLEWLGYIGSNGSSY---YQESYKGrftisKDTSKNDVSLTISNLRVEDTGTYY 78


                   ..
2OI9_C          91 CA 92
Cdd:smart00406  79 CA 80
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 16-109 5.97e-07

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 44.61  E-value: 5.97e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OI9_C       16 GEKVTLSCNQ---TNNHNNMYWYRQDTGHELRLI-YYSYGAGSTEKGDIPDGyKAS---RPSQENFSLTLESATPSQTSV 88
Cdd:cd04981  13 GQSLKLSCKAsgfTFTSYGMGWVRQAPGKGLEWIgLIYPGGGDTYYADSFKG-RFTitrDTSKSTAYLQLNSLTSEDTAV 91

                        90       100
                ....*....|....*....|....*.
2OI9_C       89 YFCASGGGGTL-----YFGAGTRLSV 109
Cdd:cd04981  92 YYCARGLGGYGysyfdYWGQGTTVTV 117
IgV_SIRP cd16097
Immunoglobulin (Ig)-like variable (V) domain of the Signal-Regulatory Protein (SIRP); The ...
 4-110 2.19e-04

Immunoglobulin (Ig)-like variable (V) domain of the Signal-Regulatory Protein (SIRP); The members here are composed of the immunoglobulin (Ig)-like domain of the Signal-Regulatory Protein (SIRP). The SIRPs belong to the "paired receptors" class of membrane proteins that comprise several genes coding for proteins with similar extracellular regions, but very different transmembrane/cytoplasmic regions with different (activating or inhibitory) signaling potentials. They are commonly on NK cells, but are also on many myeloid cells. Their extracellular region contains three immunoglobulin superfamily domains, a single V-set, and two C1-set IgSF domains. Their cytoplasmic tails that contain either ITIMs or transmembrane regions have positively charged residues that allow an association with adaptor proteins, such as DAP12/KARAP, containing ITAMs. There are 3 distinct SIRP members: alpha, beta, and gamma. SIRP alpha (also known as CD172a or SRC homology 2 domain-containing protein tyrosine phosphatase substrate 1/Shps-1) is a membrane receptor that interacts with a ligand CD47 expressed on many cells and gives an inhibitory signal through immunoreceptor tyrosine-based inhibition motifs in the cytoplasmic region that interact with phosphatases SHP-1 and SHP-2. SIRP beta has a short cytoplasmic region and associates with a transmembrane adapter protein DAP12 containing immunoreceptor tyrosine-based activation motifs to give an activating signal. SIRP gamma contains a very short cytoplasmic region lacking obvious signaling motifs, but also binds CD47 with much less affinity. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409516  Cd Length: 111  Bit Score: 37.92  E-value: 2.19e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OI9_C        4 VTQsPRNKVAVT-GEKVTLSCNQTN--NHNNMYWYRqDTGHELRLIYysygagSTEKGDIPDGYKASRPSQEN---FSLT 77
Cdd:cd16097   2 VIQ-PEKSVSVAaGESATLHCTVTSliPVGPIQWFR-GAGPGRELIY------NQKEGHFPRVTTVSDLTKRNnmdFSIR 73

                        90       100       110
                ....*....|....*....|....*....|....*...
2OI9_C       78 LESATPSQTSVYFCASGGGGT-----LYFGAGTRLSVL 110
Cdd:cd16097  74 ISNITPADAGTYYCVKFRKGSpddveFKSGAGTELSVR 111
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 4-91 3.01e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 36.77  E-value: 3.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OI9_C          4 VTQSPRNKVAVTGEKVTLSCN-QTNNHNNMYWYRQDtghelrliyysygagsteKGDIPDGYKASRPSQENFSLTLESAT 82
Cdd:pfam13927   4 ITVSPSSVTVREGETVTLTCEaTGSPPPTITWYKNG------------------EPISSGSTRSRSLSGSNSTLTISNVT 65


                  ....*....
2OI9_C         83 PSQTSVYFC 91
Cdd:pfam13927  66 RSDAGTYTC 74
IgV_CD8_alpha cd05720
Immunoglobulin (Ig)-like variable (V) domain of Cluster of Differentiation (CD) 8 alpha chain; ...
 7-104 4.44e-04

Immunoglobulin (Ig)-like variable (V) domain of Cluster of Differentiation (CD) 8 alpha chain; The members here are composed of the immunoglobulin (Ig)-like variable domain of the Cluster of Differentiation (CD) 8 alpha. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. The Ig domain of CD8 alpha binds to antibodies. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409385  Cd Length: 110  Bit Score: 37.08  E-value: 4.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OI9_C        7 SPRNKVAVTGEKVTLSCNQTNNHNN-MYWYRQDTGHELRLIYYSYGAGSTeKGDIPDGYKASR----PSQENFSLTLESA 81
Cdd:cd05720   4 SPRKRDAQLGQKVELVCEVLNSVPQgCSWLFQPRGSAPQPTFLLYLSSSN-KTKWAEGLDSKRfsgsRSGSSYVLTLKDF 82

                        90       100
                ....*....|....*....|...
2OI9_C       82 TPSQTSVYFCASGGGGTLYFGAG 104
Cdd:cd05720  83 RKEDEGYYFCSVISNSVLYFSSF 105
IgV_TCR_gammadelta cd20988
Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the ...
 16-109 6.04e-04

Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409580  Cd Length: 114  Bit Score: 36.77  E-value: 6.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OI9_C       16 GEKVTLSCN---QTNNHNNMYWYRQDTGHELRLIYYS---YGAGstekgdIPDGYKASRPSQENFS-LTLESATPSQTSV 88
Cdd:cd20988  13 GKPVTLKCSmkgEAISNYYINWYRKTQGNTMTFIYREggiYGPG------FKDNFRGDIDSSNNLAvLKILEASERDEGS 86

                        90       100
                ....*....|....*....|....*..
2OI9_C       89 YFCASG--GGGTLY----FGAGTRLSV 109
Cdd:cd20988  87 YYCASDtpGGGREYdpliFGKGTYLTV 113
IgV_B7-H2 cd20935
Immunoglobulin Variable (IgV) domain of B7-H2 (B7 homolog 2); The members here are composed of ...
 13-91 2.31e-03

Immunoglobulin Variable (IgV) domain of B7-H2 (B7 homolog 2); The members here are composed of the immunoglobulin variable (IgV) domain of B7-H2 (B7 homolog 2 also known as ICOSL (inducible T cell costimulator ligand) or CD275). B7-H2 is a ligand for the T-cell-specific cell surface receptor ICOS and acts as a costimulatory signal for T-cell proliferation and cytokine secretion. The interaction of ICOS with ICOSL (B7-H2) regulates T cell activation and expansion, is involved in T cell dependent B cell activation, and T-helper cell differentiation. It is a member of the B7 family of immune regulatory proteins and shares homology with other B7 ligands, such as B7-1, B7-2, B7-H1 (PD-L1), PD-L2, and B7-H3. The extracellular domains of B7 proteins contain two Ig-like domains and all members have short cytoplasmic domains. These ligands are typically expressed on antigen presenting cells (such as macrophages, B cells and dendritic cells) and have the ability to regulate T-cell proliferation and function. Tumor cells are also capable of expressing the B7 family members in order to evade immune surveillance.


Pssm-ID: 409529  Cd Length: 113  Bit Score: 35.22  E-value: 2.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OI9_C       13 AVTGEKVTLSC----NQTNNHNNMYWYRQDTGHELRLIYYSYGAGSTEKGD---------IPDGYKasrpsQENFSLTLE 79
Cdd:cd20935   5 AMVGSDVELSCicpeGSRFDLNDLYVYWQISESETVVTYHLPQNSSLENVDshyrnrallSLDSMK-----QGDFSLRLF 79

                        90
                ....*....|..
2OI9_C       80 SATPSQTSVYFC 91
Cdd:cd20935  80 NVTPQDEQKFHC 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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