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Conserved domains on  [gi|295321476|pdb|2KR6|A]
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Chain A, Presenilin-1

Protein Classification

A22B family peptidase( domain architecture ID 3497)

A22B family peptidase similar to Arabidopsis thaliana signal peptide peptidase-like 1, an intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Presenilin super family cl47627
Presenilin; Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It ...
 1-166 4.92e-52

Presenilin; Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It has been found that presenilin-1 binds to beta-catenin in-vivo. This family also contains SPE proteins from C.elegans.


The actual alignment was detected with superfamily member pfam01080:

Pssm-ID: 460052  Cd Length: 394  Bit Score: 170.48  E-value: 4.92e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2KR6_A          1 MVWL-----VNMAEGDPEAQRRVSKNSKYN-AESTERESQDTVAENDDggfSEEWEAQRDSHLGPHRSTPESRAAVQELS 74
Cdd:pfam01080 220 MVWLyagsqVAMSDEGTSARTVKQTISNYSkNEASESEFSQSSRSSRT---ANPDSGLTWPTSPPELSSERSEEAQSPLS 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2KR6_A         75 SSILAGEDPEE--------RGVKLGLGDFIFYSVLVGKASAtaSGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPI 146
Cdd:pfam01080 297 SSTEESSEPEEnrnklndsRGVKLGLGDFIFYSVLVGKAAM--YGDWNTVIACFVAILIGLCLTLLLLAIFKKALPALPI 374

                         170       180
                  ....*....|....*....|
2KR6_A        147 SITFGLVFYFATDYLVQPFM 166
Cdd:pfam01080 375 SIAFGLIFYFSTRFLVEPFV 394
 
Name Accession Description Interval E-value
Presenilin pfam01080
Presenilin; Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It ...
 1-166 4.92e-52

Presenilin; Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It has been found that presenilin-1 binds to beta-catenin in-vivo. This family also contains SPE proteins from C.elegans.


Pssm-ID: 460052  Cd Length: 394  Bit Score: 170.48  E-value: 4.92e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2KR6_A          1 MVWL-----VNMAEGDPEAQRRVSKNSKYN-AESTERESQDTVAENDDggfSEEWEAQRDSHLGPHRSTPESRAAVQELS 74
Cdd:pfam01080 220 MVWLyagsqVAMSDEGTSARTVKQTISNYSkNEASESEFSQSSRSSRT---ANPDSGLTWPTSPPELSSERSEEAQSPLS 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2KR6_A         75 SSILAGEDPEE--------RGVKLGLGDFIFYSVLVGKASAtaSGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPI 146
Cdd:pfam01080 297 SSTEESSEPEEnrnklndsRGVKLGLGDFIFYSVLVGKAAM--YGDWNTVIACFVAILIGLCLTLLLLAIFKKALPALPI 374

                         170       180
                  ....*....|....*....|
2KR6_A        147 SITFGLVFYFATDYLVQPFM 166
Cdd:pfam01080 375 SIAFGLIFYFSTRFLVEPFV 394
PSN smart00730
Presenilin, signal peptide peptidase, family; Presenilin 1 and presenilin 2 are polytopic ...
 82-162 9.48e-24

Presenilin, signal peptide peptidase, family; Presenilin 1 and presenilin 2 are polytopic membrane proteins, whose genes are mutated in some individuals with Alzheimer's disease. Distant homologues, present in eukaryotes and archaea, also contain conserved aspartic acid residues which are predicted to contribute to catalysis. At least one member of this family has been shown to possess signal peptide peptidase activity.


Pssm-ID: 214793  Cd Length: 249  Bit Score: 93.47  E-value: 9.48e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2KR6_A          82 DPEERGVKLGLGDFIFYSVLVGKASATAS---GDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFAT 158
Cdd:smart00730 166 DEEERFSMLGLGDIVFPGILVASAARFDVsvrSDSNYFLACFVAYGIGLILTLVLLALFKKAQPALPYLVPFTLVFYLLT 245


                   ....
2KR6_A         159 DYLV 162
Cdd:smart00730 246 ALLR 249
 
Name Accession Description Interval E-value
Presenilin pfam01080
Presenilin; Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It ...
 1-166 4.92e-52

Presenilin; Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It has been found that presenilin-1 binds to beta-catenin in-vivo. This family also contains SPE proteins from C.elegans.


Pssm-ID: 460052  Cd Length: 394  Bit Score: 170.48  E-value: 4.92e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2KR6_A          1 MVWL-----VNMAEGDPEAQRRVSKNSKYN-AESTERESQDTVAENDDggfSEEWEAQRDSHLGPHRSTPESRAAVQELS 74
Cdd:pfam01080 220 MVWLyagsqVAMSDEGTSARTVKQTISNYSkNEASESEFSQSSRSSRT---ANPDSGLTWPTSPPELSSERSEEAQSPLS 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2KR6_A         75 SSILAGEDPEE--------RGVKLGLGDFIFYSVLVGKASAtaSGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPI 146
Cdd:pfam01080 297 SSTEESSEPEEnrnklndsRGVKLGLGDFIFYSVLVGKAAM--YGDWNTVIACFVAILIGLCLTLLLLAIFKKALPALPI 374

                         170       180
                  ....*....|....*....|
2KR6_A        147 SITFGLVFYFATDYLVQPFM 166
Cdd:pfam01080 375 SIAFGLIFYFSTRFLVEPFV 394
PSN smart00730
Presenilin, signal peptide peptidase, family; Presenilin 1 and presenilin 2 are polytopic ...
 82-162 9.48e-24

Presenilin, signal peptide peptidase, family; Presenilin 1 and presenilin 2 are polytopic membrane proteins, whose genes are mutated in some individuals with Alzheimer's disease. Distant homologues, present in eukaryotes and archaea, also contain conserved aspartic acid residues which are predicted to contribute to catalysis. At least one member of this family has been shown to possess signal peptide peptidase activity.


Pssm-ID: 214793  Cd Length: 249  Bit Score: 93.47  E-value: 9.48e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2KR6_A          82 DPEERGVKLGLGDFIFYSVLVGKASATAS---GDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFAT 158
Cdd:smart00730 166 DEEERFSMLGLGDIVFPGILVASAARFDVsvrSDSNYFLACFVAYGIGLILTLVLLALFKKAQPALPYLVPFTLVFYLLT 245


                   ....
2KR6_A         159 DYLV 162
Cdd:smart00730 246 ALLR 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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