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Conserved domains on  [gi|118138319|pdb|2IBG|D]
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Chain D, CG9211-PA

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10045852)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

CATH:  2.60.40.10
Gene Ontology:  GO:0005515
PubMed:  19576999|9837732|8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 4-102 1.63e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 1.63e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IBG_D        4 PPTPPNVTRLSDESVMLRWMVPRNDGLPIVIFKVQYRMVGkRKNWQTtndnipygkpkWNSELGKSFTASVTDLKPQHTY 83
Cdd:cd00063   3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKG-SGDWKE-----------VEVTPGSETSYTLTGLKPGTEY 70

                        90
                ....*....|....*....
2IBG_D       84 RFRILAVYSNNDNKESNTS 102
Cdd:cd00063  71 EFRVRAVNGGGESPPSESV 89
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
64-190 2.83e-05

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.22  E-value: 2.83e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IBG_D       64 SELGKSFTASVTD--LKPQHTYRFRILAVysNNDNKESNTSAKFYLQPGAAldPMPVPELLEIEEYSETAVVLHWSLASD 141
Cdd:COG3401 277 TKVATVTTTSYTDtgLTNGTTYYYRVTAV--DAAGNESAPSNVVSVTTDLT--PPAAPSGLTATAVGSSSITLSWTASSD 352

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
2IBG_D      142 ADehlITGYYaYYRPSSSAGEYFKATiEGAHARSFKIAPLETATMYEFK 190
Cdd:COG3401 353 AD---VTGYN-VYRSTSGGGTYTKIA-ETVTTTSYTDTGLTPGTTYYYK 396
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 4-102 1.63e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 1.63e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IBG_D        4 PPTPPNVTRLSDESVMLRWMVPRNDGLPIVIFKVQYRMVGkRKNWQTtndnipygkpkWNSELGKSFTASVTDLKPQHTY 83
Cdd:cd00063   3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKG-SGDWKE-----------VEVTPGSETSYTLTGLKPGTEY 70

                        90
                ....*....|....*....
2IBG_D       84 RFRILAVYSNNDNKESNTS 102
Cdd:cd00063  71 EFRVRAVNGGGESPPSESV 89
fn3 pfam00041
Fibronectin type III domain;
4-99 9.79e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.57  E-value: 9.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IBG_D          4 PPTPPNVTRLSDESVMLRWMVPRNDGLPIVIFKVQYRMVGKRKNWQTTNDNIPygkpkwnselgkSFTASVTDLKPQHTY 83
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT------------TTSVTLTGLKPGTEY 69

                          90
                  ....*....|....*.
2IBG_D         84 RFRILAVYSNNDNKES 99
Cdd:pfam00041  70 EVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 4-93 8.35e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 8.35e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IBG_D           4 PPTPPNVTRLSDESVMLRWMVPRNDGL--PIVIFKVQYRmvGKRKNWQTTNDNipygkpkwnselGKSFTASVTDLKPQH 81
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPPDDGItgYIVGYRVEYR--EEGSEWKEVNVT------------PSSTSYTLTGLKPGT 68

                           90
                   ....*....|..
2IBG_D          82 TYRFRILAVYSN 93
Cdd:smart00060  69 EYEFRVRAVNGA 80
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
64-190 2.83e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.22  E-value: 2.83e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IBG_D       64 SELGKSFTASVTD--LKPQHTYRFRILAVysNNDNKESNTSAKFYLQPGAAldPMPVPELLEIEEYSETAVVLHWSLASD 141
Cdd:COG3401 277 TKVATVTTTSYTDtgLTNGTTYYYRVTAV--DAAGNESAPSNVVSVTTDLT--PPAAPSGLTATAVGSSSITLSWTASSD 352

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
2IBG_D      142 ADehlITGYYaYYRPSSSAGEYFKATiEGAHARSFKIAPLETATMYEFK 190
Cdd:COG3401 353 AD---VTGYN-VYRSTSGGGTYTKIA-ETVTTTSYTDTGLTPGTTYYYK 396
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 119-192 5.04e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.94  E-value: 5.04e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
2IBG_D      119 PELLEIEEYSETAVVLHWSlASDADEHLITGYYAYYRPSSSaGEYFKATIEGAHARSFKIAPLETATMYEFKLQ 192
Cdd:cd00063   4 PTNLRVTDVTSTSVTLSWT-PPEDDGGPITGYVVEYREKGS-GDWKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 4-102 1.63e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 1.63e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IBG_D        4 PPTPPNVTRLSDESVMLRWMVPRNDGLPIVIFKVQYRMVGkRKNWQTtndnipygkpkWNSELGKSFTASVTDLKPQHTY 83
Cdd:cd00063   3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKG-SGDWKE-----------VEVTPGSETSYTLTGLKPGTEY 70

                        90
                ....*....|....*....
2IBG_D       84 RFRILAVYSNNDNKESNTS 102
Cdd:cd00063  71 EFRVRAVNGGGESPPSESV 89
fn3 pfam00041
Fibronectin type III domain;
4-99 9.79e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.57  E-value: 9.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IBG_D          4 PPTPPNVTRLSDESVMLRWMVPRNDGLPIVIFKVQYRMVGKRKNWQTTNDNIPygkpkwnselgkSFTASVTDLKPQHTY 83
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT------------TTSVTLTGLKPGTEY 69

                          90
                  ....*....|....*.
2IBG_D         84 RFRILAVYSNNDNKES 99
Cdd:pfam00041  70 EVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 4-93 8.35e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 8.35e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IBG_D           4 PPTPPNVTRLSDESVMLRWMVPRNDGL--PIVIFKVQYRmvGKRKNWQTTNDNipygkpkwnselGKSFTASVTDLKPQH 81
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPPDDGItgYIVGYRVEYR--EEGSEWKEVNVT------------PSSTSYTLTGLKPGT 68

                           90
                   ....*....|..
2IBG_D          82 TYRFRILAVYSN 93
Cdd:smart00060  69 EYEFRVRAVNGA 80
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
64-190 2.83e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.22  E-value: 2.83e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IBG_D       64 SELGKSFTASVTD--LKPQHTYRFRILAVysNNDNKESNTSAKFYLQPGAAldPMPVPELLEIEEYSETAVVLHWSLASD 141
Cdd:COG3401 277 TKVATVTTTSYTDtgLTNGTTYYYRVTAV--DAAGNESAPSNVVSVTTDLT--PPAAPSGLTATAVGSSSITLSWTASSD 352

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
2IBG_D      142 ADehlITGYYaYYRPSSSAGEYFKATiEGAHARSFKIAPLETATMYEFK 190
Cdd:COG3401 353 AD---VTGYN-VYRSTSGGGTYTKIA-ETVTTTSYTDTGLTPGTTYYYK 396
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 119-192 5.04e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.94  E-value: 5.04e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
2IBG_D      119 PELLEIEEYSETAVVLHWSlASDADEHLITGYYAYYRPSSSaGEYFKATIEGAHARSFKIAPLETATMYEFKLQ 192
Cdd:cd00063   4 PTNLRVTDVTSTSVTLSWT-PPEDDGGPITGYVVEYREKGS-GDWKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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