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Conserved domains on  [gi|146387242|pdb|2EJN|B]
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Chain B, Major allergen I polypeptide chain 1, chain 2

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UTG smart00096
Uteroglobin;
2-71 7.25e-32

Uteroglobin;


:

Pssm-ID: 128407  Cd Length: 69  Bit Score: 108.38  E-value: 7.25e-32
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2EJN_B           2 EICPAVKRDVDLFLTGTPDEYVEQVAQYKALPVVLENARILKNCVDAkMTEEDKENALSLLDKIYTSPLC 71
Cdd:smart00096   1 EICPGFKRVIELLLLGTPSSYEASLKQFKPDPDMLEAGRQLKKLVDT-LPQETRENILKLTEKIYTSPLC 69
Feld-I_B pfam09252
Allergen Fel d I-B chain; Members of this family of cat allergens adopt a helical structure ...
 78-144 4.40e-31

Allergen Fel d I-B chain; Members of this family of cat allergens adopt a helical structure consisting of eight alpha helices, in a Uteroglobin-like fold. They are one of the most important causes of allergic asthma worldwide.


:

Pssm-ID: 462724  Cd Length: 67  Bit Score: 106.28  E-value: 4.40e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
2EJN_B         78 CPIFYDVFFAVANGNELLLDLSLTKVNATEPERTAMKKIQDCYVENGLISRVLDGLVMTTISSSKDC 144
Cdd:pfam09252   1 CPPFYGVYGAVLSGSRTLLNAELSLFNATDEEKVAFEKIQDCYNEEGLKAKLLDPQIMTSILFSPEC 67
 
Name Accession Description Interval E-value
UTG smart00096
Uteroglobin;
2-71 7.25e-32

Uteroglobin;


Pssm-ID: 128407  Cd Length: 69  Bit Score: 108.38  E-value: 7.25e-32
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2EJN_B           2 EICPAVKRDVDLFLTGTPDEYVEQVAQYKALPVVLENARILKNCVDAkMTEEDKENALSLLDKIYTSPLC 71
Cdd:smart00096   1 EICPGFKRVIELLLLGTPSSYEASLKQFKPDPDMLEAGRQLKKLVDT-LPQETRENILKLTEKIYTSPLC 69
Feld-I_B pfam09252
Allergen Fel d I-B chain; Members of this family of cat allergens adopt a helical structure ...
 78-144 4.40e-31

Allergen Fel d I-B chain; Members of this family of cat allergens adopt a helical structure consisting of eight alpha helices, in a Uteroglobin-like fold. They are one of the most important causes of allergic asthma worldwide.


Pssm-ID: 462724  Cd Length: 67  Bit Score: 106.28  E-value: 4.40e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
2EJN_B         78 CPIFYDVFFAVANGNELLLDLSLTKVNATEPERTAMKKIQDCYVENGLISRVLDGLVMTTISSSKDC 144
Cdd:pfam09252   1 CPPFYGVYGAVLSGSRTLLNAELSLFNATDEEKVAFEKIQDCYNEEGLKAKLLDPQIMTSILFSPEC 67
Uteroglobin pfam01099
Uteroglobin family; Uteroglobin is a homodimer of two identical 70 amino acid polypeptides ...
 2-71 2.11e-22

Uteroglobin family; Uteroglobin is a homodimer of two identical 70 amino acid polypeptides linked by two disulphide bridges. The precise role of uteroglobin has still to be elucidated.


Pssm-ID: 460063  Cd Length: 90  Bit Score: 84.96  E-value: 2.11e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2EJN_B          2 EICPAVKRDVDLFLTGTPDEYVEQVAQYKALPVVLENARILKNCVDaKMTEEDKENALSLLDKIYTSPLC 71
Cdd:pfam01099  22 DGCPALEEVVEKFLFGSEEEYKESLEKYNPPPEAVEAKLELKQCFD-KLSNETRLNIAKLLEKILLSPLC 90
Secretoglobin cd00633
Secretoglobins are relatively small, secreted, disulphide-bridged dimeric proteins with ...
 4-71 6.22e-18

Secretoglobins are relatively small, secreted, disulphide-bridged dimeric proteins with encoding genes sharing substantial sequence similarity. Their family subunits may be grouped into five subfamilies, A-E. Uteroglobin (subfamily A), which is identical to Clara cell protein (CC10), forms a globular shaped homodimer with a large hydrophobic pocket located between the two dimers. The uteroglobin monomer structure is composed of four alpha helices that do not form a canonical four helix-bundle motif but rather a boomerang-shaped structure in which helices H1, H3, and H4 are able to bind a homodimeric partner. The hydrophobic pocket binds steroids, particularly progesterone, with high specificity. However, the true biological function of uteroglobin is poorly understood. In mammals, uteroglobin has immunosuppressive and anti-inflammatory properties through the inhibition of phospholipase A2. The other four main subfamilies of secretoglobins are found in heterodimeric combinations, with B and C subfamilies disulphide-bridged to the E and D subfamilies, respectively. [See review by Laukaitis C.M. _ Karn R.C. (2005). Biological Journal of the Linnean Society 84, 493]. These include rat prostatic steroid-binding protein (PBP or prostatein), human mammaglobin (or heteroglobin), lipophilins, major cat allergen Fel dI, the hamster Harderian gland proteins and mouse salivary androgen-binding protein (ABP). Example of such a heterodimer: ABPalpha-like sequences are closely related to cat Fel dI chain 1, whereas ABPbeta-gamma-like sequences are closely related to Fel dI chain 2. Thus, the heterodimeric structure of ABPalpha-beta and ABPalpha-gamma is recapitulated by the sequence-similar Fel dI chains 1 and 2. This conservation of primary and quaternary structure indicates that the genome of the eutherian common ancestor of cats, rodents, and primates contained a similar gene pair.


Pssm-ID: 238346  Cd Length: 67  Bit Score: 72.72  E-value: 6.22e-18
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
2EJN_B        4 CPAVKRDVDLFLTGTPDEYVEQVAQYKALPVVLENARILKNCVDaKMTEEDKENALSLLDKIYTSPLC 71
Cdd:cd00633   1 CPALESVIEGFLLGSEEEYKAELEKFNATPEAVEAKEKLKQCVD-EQSLETKENIAKLLEKILASPLC 67
Secretoglobin cd00633
Secretoglobins are relatively small, secreted, disulphide-bridged dimeric proteins with ...
 78-144 1.69e-14

Secretoglobins are relatively small, secreted, disulphide-bridged dimeric proteins with encoding genes sharing substantial sequence similarity. Their family subunits may be grouped into five subfamilies, A-E. Uteroglobin (subfamily A), which is identical to Clara cell protein (CC10), forms a globular shaped homodimer with a large hydrophobic pocket located between the two dimers. The uteroglobin monomer structure is composed of four alpha helices that do not form a canonical four helix-bundle motif but rather a boomerang-shaped structure in which helices H1, H3, and H4 are able to bind a homodimeric partner. The hydrophobic pocket binds steroids, particularly progesterone, with high specificity. However, the true biological function of uteroglobin is poorly understood. In mammals, uteroglobin has immunosuppressive and anti-inflammatory properties through the inhibition of phospholipase A2. The other four main subfamilies of secretoglobins are found in heterodimeric combinations, with B and C subfamilies disulphide-bridged to the E and D subfamilies, respectively. [See review by Laukaitis C.M. _ Karn R.C. (2005). Biological Journal of the Linnean Society 84, 493]. These include rat prostatic steroid-binding protein (PBP or prostatein), human mammaglobin (or heteroglobin), lipophilins, major cat allergen Fel dI, the hamster Harderian gland proteins and mouse salivary androgen-binding protein (ABP). Example of such a heterodimer: ABPalpha-like sequences are closely related to cat Fel dI chain 1, whereas ABPbeta-gamma-like sequences are closely related to Fel dI chain 2. Thus, the heterodimeric structure of ABPalpha-beta and ABPalpha-gamma is recapitulated by the sequence-similar Fel dI chains 1 and 2. This conservation of primary and quaternary structure indicates that the genome of the eutherian common ancestor of cats, rodents, and primates contained a similar gene pair.


Pssm-ID: 238346  Cd Length: 67  Bit Score: 63.86  E-value: 1.69e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
2EJN_B       78 CPIFYDVFFAVANGNELLLDLSLTKVNATEPERTAMKKIQDCYVENGLISRVLDGLVMTTISSSKDC 144
Cdd:cd00633   1 CPALESVIEGFLLGSEEEYKAELEKFNATPEAVEAKEKLKQCVDEQSLETKENIAKLLEKILASPLC 67
 
Name Accession Description Interval E-value
UTG smart00096
Uteroglobin;
2-71 7.25e-32

Uteroglobin;


Pssm-ID: 128407  Cd Length: 69  Bit Score: 108.38  E-value: 7.25e-32
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2EJN_B           2 EICPAVKRDVDLFLTGTPDEYVEQVAQYKALPVVLENARILKNCVDAkMTEEDKENALSLLDKIYTSPLC 71
Cdd:smart00096   1 EICPGFKRVIELLLLGTPSSYEASLKQFKPDPDMLEAGRQLKKLVDT-LPQETRENILKLTEKIYTSPLC 69
Feld-I_B pfam09252
Allergen Fel d I-B chain; Members of this family of cat allergens adopt a helical structure ...
 78-144 4.40e-31

Allergen Fel d I-B chain; Members of this family of cat allergens adopt a helical structure consisting of eight alpha helices, in a Uteroglobin-like fold. They are one of the most important causes of allergic asthma worldwide.


Pssm-ID: 462724  Cd Length: 67  Bit Score: 106.28  E-value: 4.40e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
2EJN_B         78 CPIFYDVFFAVANGNELLLDLSLTKVNATEPERTAMKKIQDCYVENGLISRVLDGLVMTTISSSKDC 144
Cdd:pfam09252   1 CPPFYGVYGAVLSGSRTLLNAELSLFNATDEEKVAFEKIQDCYNEEGLKAKLLDPQIMTSILFSPEC 67
Uteroglobin pfam01099
Uteroglobin family; Uteroglobin is a homodimer of two identical 70 amino acid polypeptides ...
 2-71 2.11e-22

Uteroglobin family; Uteroglobin is a homodimer of two identical 70 amino acid polypeptides linked by two disulphide bridges. The precise role of uteroglobin has still to be elucidated.


Pssm-ID: 460063  Cd Length: 90  Bit Score: 84.96  E-value: 2.11e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2EJN_B          2 EICPAVKRDVDLFLTGTPDEYVEQVAQYKALPVVLENARILKNCVDaKMTEEDKENALSLLDKIYTSPLC 71
Cdd:pfam01099  22 DGCPALEEVVEKFLFGSEEEYKESLEKYNPPPEAVEAKLELKQCFD-KLSNETRLNIAKLLEKILLSPLC 90
Secretoglobin cd00633
Secretoglobins are relatively small, secreted, disulphide-bridged dimeric proteins with ...
 4-71 6.22e-18

Secretoglobins are relatively small, secreted, disulphide-bridged dimeric proteins with encoding genes sharing substantial sequence similarity. Their family subunits may be grouped into five subfamilies, A-E. Uteroglobin (subfamily A), which is identical to Clara cell protein (CC10), forms a globular shaped homodimer with a large hydrophobic pocket located between the two dimers. The uteroglobin monomer structure is composed of four alpha helices that do not form a canonical four helix-bundle motif but rather a boomerang-shaped structure in which helices H1, H3, and H4 are able to bind a homodimeric partner. The hydrophobic pocket binds steroids, particularly progesterone, with high specificity. However, the true biological function of uteroglobin is poorly understood. In mammals, uteroglobin has immunosuppressive and anti-inflammatory properties through the inhibition of phospholipase A2. The other four main subfamilies of secretoglobins are found in heterodimeric combinations, with B and C subfamilies disulphide-bridged to the E and D subfamilies, respectively. [See review by Laukaitis C.M. _ Karn R.C. (2005). Biological Journal of the Linnean Society 84, 493]. These include rat prostatic steroid-binding protein (PBP or prostatein), human mammaglobin (or heteroglobin), lipophilins, major cat allergen Fel dI, the hamster Harderian gland proteins and mouse salivary androgen-binding protein (ABP). Example of such a heterodimer: ABPalpha-like sequences are closely related to cat Fel dI chain 1, whereas ABPbeta-gamma-like sequences are closely related to Fel dI chain 2. Thus, the heterodimeric structure of ABPalpha-beta and ABPalpha-gamma is recapitulated by the sequence-similar Fel dI chains 1 and 2. This conservation of primary and quaternary structure indicates that the genome of the eutherian common ancestor of cats, rodents, and primates contained a similar gene pair.


Pssm-ID: 238346  Cd Length: 67  Bit Score: 72.72  E-value: 6.22e-18
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
2EJN_B        4 CPAVKRDVDLFLTGTPDEYVEQVAQYKALPVVLENARILKNCVDaKMTEEDKENALSLLDKIYTSPLC 71
Cdd:cd00633   1 CPALESVIEGFLLGSEEEYKAELEKFNATPEAVEAKEKLKQCVD-EQSLETKENIAKLLEKILASPLC 67
Secretoglobin cd00633
Secretoglobins are relatively small, secreted, disulphide-bridged dimeric proteins with ...
 78-144 1.69e-14

Secretoglobins are relatively small, secreted, disulphide-bridged dimeric proteins with encoding genes sharing substantial sequence similarity. Their family subunits may be grouped into five subfamilies, A-E. Uteroglobin (subfamily A), which is identical to Clara cell protein (CC10), forms a globular shaped homodimer with a large hydrophobic pocket located between the two dimers. The uteroglobin monomer structure is composed of four alpha helices that do not form a canonical four helix-bundle motif but rather a boomerang-shaped structure in which helices H1, H3, and H4 are able to bind a homodimeric partner. The hydrophobic pocket binds steroids, particularly progesterone, with high specificity. However, the true biological function of uteroglobin is poorly understood. In mammals, uteroglobin has immunosuppressive and anti-inflammatory properties through the inhibition of phospholipase A2. The other four main subfamilies of secretoglobins are found in heterodimeric combinations, with B and C subfamilies disulphide-bridged to the E and D subfamilies, respectively. [See review by Laukaitis C.M. _ Karn R.C. (2005). Biological Journal of the Linnean Society 84, 493]. These include rat prostatic steroid-binding protein (PBP or prostatein), human mammaglobin (or heteroglobin), lipophilins, major cat allergen Fel dI, the hamster Harderian gland proteins and mouse salivary androgen-binding protein (ABP). Example of such a heterodimer: ABPalpha-like sequences are closely related to cat Fel dI chain 1, whereas ABPbeta-gamma-like sequences are closely related to Fel dI chain 2. Thus, the heterodimeric structure of ABPalpha-beta and ABPalpha-gamma is recapitulated by the sequence-similar Fel dI chains 1 and 2. This conservation of primary and quaternary structure indicates that the genome of the eutherian common ancestor of cats, rodents, and primates contained a similar gene pair.


Pssm-ID: 238346  Cd Length: 67  Bit Score: 63.86  E-value: 1.69e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
2EJN_B       78 CPIFYDVFFAVANGNELLLDLSLTKVNATEPERTAMKKIQDCYVENGLISRVLDGLVMTTISSSKDC 144
Cdd:cd00633   1 CPALESVIEGFLLGSEEEYKAELEKFNATPEAVEAKEKLKQCVDEQSLETKENIAKLLEKILASPLC 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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