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Conserved domains on  [gi|110591283|pdb|2DRU|A]
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Chain A, chimera of CD48 antigen and T-cell surface antigen CD2

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 5-103 3.24e-32

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


:

Pssm-ID: 409431  Cd Length: 98  Bit Score: 111.29  E-value: 3.24e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DRU_A        5 SVPNVNAITGSNVTLTILKHPlASYQRLTWLHTTnQKILEYFPNGKKTVFESvFKDRVDLDKTNGALRIYNVSKEDRGDY 84
Cdd:cd05775   1 SSGEVYGALGGNVTLTISSLQ-DDIDEIKWKKTK-DKIVEWENNIGPTYFGS-FKDRVLLDKESGSLTIKNLTKEDSGTY 77

                        90       100
                ....*....|....*....|.
2DRU_A       85 YMRMLHE--TEDQWKITMEVY 103
Cdd:cd05775  78 ELEITSTngKVLSSKFTLEVL 98
C2-set pfam05790
Immunoglobulin C2-set domain;
111-180 4.41e-14

Immunoglobulin C2-set domain;


:

Pssm-ID: 399065  Cd Length: 80  Bit Score: 63.90  E-value: 4.41e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
2DRU_A        111 IYWECSNATLTCEVLEGT-------DVELKLYQGKEHLRSLRQKTMSYQWT-NLRAPFKCKA-VNRVSQESEMEVVNCP 180
Cdd:pfam05790   1 VTVSCSNNLLTCEVLELTlpkgskmDPSLKLKGQEAKSLETKKLESTFQPTtEDSGTWVCLAsDNDQKKLESVIEVLVL 79
 
Name Accession Description Interval E-value
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 5-103 3.24e-32

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 111.29  E-value: 3.24e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DRU_A        5 SVPNVNAITGSNVTLTILKHPlASYQRLTWLHTTnQKILEYFPNGKKTVFESvFKDRVDLDKTNGALRIYNVSKEDRGDY 84
Cdd:cd05775   1 SSGEVYGALGGNVTLTISSLQ-DDIDEIKWKKTK-DKIVEWENNIGPTYFGS-FKDRVLLDKESGSLTIKNLTKEDSGTY 77

                        90       100
                ....*....|....*....|.
2DRU_A       85 YMRMLHE--TEDQWKITMEVY 103
Cdd:cd05775  78 ELEITSTngKVLSSKFTLEVL 98
C2-set pfam05790
Immunoglobulin C2-set domain;
111-180 4.41e-14

Immunoglobulin C2-set domain;


Pssm-ID: 399065  Cd Length: 80  Bit Score: 63.90  E-value: 4.41e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
2DRU_A        111 IYWECSNATLTCEVLEGT-------DVELKLYQGKEHLRSLRQKTMSYQWT-NLRAPFKCKA-VNRVSQESEMEVVNCP 180
Cdd:pfam05790   1 VTVSCSNNLLTCEVLELTlpkgskmDPSLKLKGQEAKSLETKKLESTFQPTtEDSGTWVCLAsDNDQKKLESVIEVLVL 79
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 9-96 5.34e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 37.82  E-value: 5.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DRU_A          9 VNAITGSNVTLTILKHPLASY--QRLTWL-----HTTNQKILEYFPNGKKTVFESVFKDRVDLDKTNGALRIYNVSKEDR 81
Cdd:pfam07686   6 VTVALGGSVTLPCTYSSSMSEasTSVYWYrqppgKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLTLSDS 85

                          90
                  ....*....|....*
2DRU_A         82 GDYYMRMLHETEDQW 96
Cdd:pfam07686  86 GTYTCAVIPSGEGVF 100
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 7-85 9.19e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.71  E-value: 9.19e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
2DRU_A           7 PNVNAITGSNVTLTIlKHPLASYQRLTWLHTTNQKILEyfpNGKKTVFESvfkdrvdldKTNGALRIYNVSKEDRGDYY 85
Cdd:smart00410   2 PSVTVKEGESVTLSC-EASGSPPPEVTWYKQGGKLLAE---SGRFSVSRS---------GSTSTLTISNVTPEDSGTYT 67
 
Name Accession Description Interval E-value
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 5-103 3.24e-32

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 111.29  E-value: 3.24e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DRU_A        5 SVPNVNAITGSNVTLTILKHPlASYQRLTWLHTTnQKILEYFPNGKKTVFESvFKDRVDLDKTNGALRIYNVSKEDRGDY 84
Cdd:cd05775   1 SSGEVYGALGGNVTLTISSLQ-DDIDEIKWKKTK-DKIVEWENNIGPTYFGS-FKDRVLLDKESGSLTIKNLTKEDSGTY 77

                        90       100
                ....*....|....*....|.
2DRU_A       85 YMRMLHE--TEDQWKITMEVY 103
Cdd:cd05775  78 ELEITSTngKVLSSKFTLEVL 98
C2-set pfam05790
Immunoglobulin C2-set domain;
111-180 4.41e-14

Immunoglobulin C2-set domain;


Pssm-ID: 399065  Cd Length: 80  Bit Score: 63.90  E-value: 4.41e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
2DRU_A        111 IYWECSNATLTCEVLEGT-------DVELKLYQGKEHLRSLRQKTMSYQWT-NLRAPFKCKA-VNRVSQESEMEVVNCP 180
Cdd:pfam05790   1 VTVSCSNNLLTCEVLELTlpkgskmDPSLKLKGQEAKSLETKKLESTFQPTtEDSGTWVCLAsDNDQKKLESVIEVLVL 79
IgV_CEACAM_like cd05741
Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion ...
 9-88 4.40e-06

Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and related domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface. This family corresponds to the D1 Ig-like domain. Also belonging to this group is the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84-like family. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. SLAM family proteins are organized as an extracellular domain with having two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409403  Cd Length: 102  Bit Score: 43.28  E-value: 4.40e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DRU_A        9 VNAITGSNVTLTI--LKHPLASYQrltWLHT----TNQKILEYFPNGKKTVFESVFKDRVDLDkTNGALRIYNVSKEDRG 82
Cdd:cd05741   5 FYGAEGKNVLLLVpnLQTPLKSVS---WYKGkqvsRNDEIAEYENSSDEFRAGSAFSGREYIY-TNGSLLIQNITLSDTG 80


                ....*.
2DRU_A       83 DYYMRM 88
Cdd:cd05741  81 FYTLES 86
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 9-96 5.34e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 37.82  E-value: 5.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DRU_A          9 VNAITGSNVTLTILKHPLASY--QRLTWL-----HTTNQKILEYFPNGKKTVFESVFKDRVDLDKTNGALRIYNVSKEDR 81
Cdd:pfam07686   6 VTVALGGSVTLPCTYSSSMSEasTSVYWYrqppgKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLTLSDS 85

                          90
                  ....*....|....*
2DRU_A         82 GDYYMRMLHETEDQW 96
Cdd:pfam07686  86 GTYTCAVIPSGEGVF 100
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 7-85 9.19e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.71  E-value: 9.19e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
2DRU_A           7 PNVNAITGSNVTLTIlKHPLASYQRLTWLHTTNQKILEyfpNGKKTVFESvfkdrvdldKTNGALRIYNVSKEDRGDYY 85
Cdd:smart00410   2 PSVTVKEGESVTLSC-EASGSPPPEVTWYKQGGKLLAE---SGRFSVSRS---------GSTSTLTISNVTPEDSGTYT 67
IGv smart00406
Immunoglobulin V-Type;
16-85 4.04e-03

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 34.67  E-value: 4.04e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
2DRU_A          16 NVTLT-ILKHPLASYQRLTWLHTTNQKILE---YFPNGKKTVFESVFKDRV----DLDKTNGALRIYNVSKEDRGDYY 85
Cdd:smart00406   1 SVTLScKFSGSTFSSYYVSWVRQPPGKGLEwlgYIGSNGSSYYQESYKGRFtiskDTSKNDVSLTISNLRVEDTGTYY 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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