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Conserved domains on  [gi|145579154|pdb|2DI3|B]
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Chain B, Bacterial regulatory proteins, GntR family

Protein Classification

FadR/GntR family transcriptional regulator( domain architecture ID 11450686)

helix-turn-helix transcriptional regulator belonging to the GntR family, which contains FadR, HutC, MocR, YtrA, AraR, PlmA, and many other subfamilies

CATH:  1.10.10.10
Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763
SCOP:  4000155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
4-223 2.89e-46

DNA-binding transcriptional regulator, FadR family [Transcription];


:

Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 153.55  E-value: 2.89e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B        4 KAHESVMDWVTEELRSGRLKIGDHLPSERALSETLGVSRSSLREALRVLEALGTISTATGsgprSGTIITAAPGQALSLS 83
Cdd:COG2186   7 SLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQG----GGTFVREPSPWALLDP 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B       84 VTLQLVTNQVGHHDIYETRQLLEGWAALHSSAERGDWDVA--EALLEKMDDPSLPLEDFLRFDAEFHVVISKGAENPLIS 161
Cdd:COG2186  83 LALLLALDDASLRDLLEARLALEPEAARLAAERATDEDLArlEAALAEMEAAADDGEAFAEADLAFHRAIAEASGNPLLA 162

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
2DI3_B      162 TLMEALRLSVADHTVARARalpdWRATSARLQKEHRAILAALRAGESTVAATLIKEHIEGYY 223
Cdd:COG2186 163 LLLESLRELLRRSVRLTLR----SPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVR 220
 
Name Accession Description Interval E-value
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
4-223 2.89e-46

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 153.55  E-value: 2.89e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B        4 KAHESVMDWVTEELRSGRLKIGDHLPSERALSETLGVSRSSLREALRVLEALGTISTATGsgprSGTIITAAPGQALSLS 83
Cdd:COG2186   7 SLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQG----GGTFVREPSPWALLDP 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B       84 VTLQLVTNQVGHHDIYETRQLLEGWAALHSSAERGDWDVA--EALLEKMDDPSLPLEDFLRFDAEFHVVISKGAENPLIS 161
Cdd:COG2186  83 LALLLALDDASLRDLLEARLALEPEAARLAAERATDEDLArlEAALAEMEAAADDGEAFAEADLAFHRAIAEASGNPLLA 162

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
2DI3_B      162 TLMEALRLSVADHTVARARalpdWRATSARLQKEHRAILAALRAGESTVAATLIKEHIEGYY 223
Cdd:COG2186 163 LLLESLRELLRRSVRLTLR----SPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVR 220
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 4-220 2.09e-17

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 78.14  E-value: 2.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B         4 KAHESVMDWVTEELRSGRLKIGDHLPSERALSETLGVSRSSLREALRVLEALGTISTATG-----SGPRSGTIItaapgQ 78
Cdd:PRK03837  13 KLSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGerarvSRPSADTII-----G 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B        79 ALSLSVTLQLVTNQVGHHDIYETRQLLEGWAALHSSAERGDWDVA--EALLEKMDDPSLPLEDFLRFDAEFHVVISKGAE 156
Cdd:PRK03837  88 QLSGMAKDFLSQSPDGLAHLKQARLFFESSLARYAAEHATDEQIAllRKALERNSQSLGDNAAFIRSDMEFHRVIAEIPG 167

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
2DI3_B       157 NPLISTLMEALrlsvADHTVARARALPDWRATSARLQKEHRAILAALRAGESTVAATLIKEHIE 220
Cdd:PRK03837 168 NPIFMAIHEAL----LDWLIEARPEVVILHGHENVTLQEHIAIVDAIRAHDPDEADRALQSHLN 227
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 6-65 2.78e-16

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 70.55  E-value: 2.78e-16
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B        6 HESVMDWVTEELRSGRLKIGDHLPSERALSETLGVSRSSLREALRVLEALGTISTATGSG 65
Cdd:cd07377   3 YEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRG 62
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 97-221 2.07e-15

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 70.08  E-value: 2.07e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B          97 DIYETRQLLEGWAAlHSSAERG---DWDVAEALLEKMD---DPSLPLEDFLRFDAEFHVVISKGAENPLISTLMEALRLS 170
Cdd:smart00895   1 ELYEVRRALEPLAA-RLAAERAtdeDLAALEALLDAMEaaaAAGDDLEEFAELDREFHRALAEAAGNPVLLELLESLRAR 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
2DI3_B         171 VADHTVARARALpdwratsARLQKEHRAILAALRAGESTVAATLIKEHIEG 221
Cdd:smart00895  80 LRRLRRLSLEAA-------RRALDEHRAILDAIRARDAEAARAAMREHLEA 123
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 7-65 7.22e-12

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 58.78  E-value: 7.22e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
2DI3_B          7 ESVMDWVTEELRSGRLKIGDHLPSERALSETLGVSRSSLREALRVLEALGTISTATGSG 65
Cdd:pfam00392   3 EQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRG 61
 
Name Accession Description Interval E-value
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
4-223 2.89e-46

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 153.55  E-value: 2.89e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B        4 KAHESVMDWVTEELRSGRLKIGDHLPSERALSETLGVSRSSLREALRVLEALGTISTATGsgprSGTIITAAPGQALSLS 83
Cdd:COG2186   7 SLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQG----GGTFVREPSPWALLDP 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B       84 VTLQLVTNQVGHHDIYETRQLLEGWAALHSSAERGDWDVA--EALLEKMDDPSLPLEDFLRFDAEFHVVISKGAENPLIS 161
Cdd:COG2186  83 LALLLALDDASLRDLLEARLALEPEAARLAAERATDEDLArlEAALAEMEAAADDGEAFAEADLAFHRAIAEASGNPLLA 162

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
2DI3_B      162 TLMEALRLSVADHTVARARalpdWRATSARLQKEHRAILAALRAGESTVAATLIKEHIEGYY 223
Cdd:COG2186 163 LLLESLRELLRRSVRLTLR----SPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVR 220
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
1-220 3.49e-24

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 96.14  E-value: 3.49e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B        1 MSVKAHESVMDWVTEELR----SGRLKIGDHLpSERALSETLGVSRSSLREALRVLEALGTISTAtgsgPRSGTIITaap 76
Cdd:COG1802   4 PSPLRRESLAEQVYEALReailSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIR----PNRGARVA--- 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B       77 gqalslSVTLQLVtnqvghHDIYETRQLLEGwAALHSSAERG---DWDVAEALLEKMDD--PSLPLEDFLRFDAEFHVVI 151
Cdd:COG1802  76 ------PLSPEEI------RELYEVRAALEG-LAARLAAERAtpaDLARLRALLEELEAaaAAGDVAAYLELDREFHRAL 142

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
2DI3_B      152 SKGAENPLISTLMEALRLSVADHTVARARALPDWRATSArlqkEHRAILAALRAGESTVAATLIKEHIE 220
Cdd:COG1802 143 VEAAGNPRLAELLRRLRARLRRYRRLSLRSPGRLEESLA----EHRAILDALEAGDAEAAAAALRAHLE 207
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 4-220 2.09e-17

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 78.14  E-value: 2.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B         4 KAHESVMDWVTEELRSGRLKIGDHLPSERALSETLGVSRSSLREALRVLEALGTISTATG-----SGPRSGTIItaapgQ 78
Cdd:PRK03837  13 KLSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGerarvSRPSADTII-----G 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B        79 ALSLSVTLQLVTNQVGHHDIYETRQLLEGWAALHSSAERGDWDVA--EALLEKMDDPSLPLEDFLRFDAEFHVVISKGAE 156
Cdd:PRK03837  88 QLSGMAKDFLSQSPDGLAHLKQARLFFESSLARYAAEHATDEQIAllRKALERNSQSLGDNAAFIRSDMEFHRVIAEIPG 167

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
2DI3_B       157 NPLISTLMEALrlsvADHTVARARALPDWRATSARLQKEHRAILAALRAGESTVAATLIKEHIE 220
Cdd:PRK03837 168 NPIFMAIHEAL----LDWLIEARPEVVILHGHENVTLQEHIAIVDAIRAHDPDEADRALQSHLN 227
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 6-65 2.78e-16

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 70.55  E-value: 2.78e-16
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B        6 HESVMDWVTEELRSGRLKIGDHLPSERALSETLGVSRSSLREALRVLEALGTISTATGSG 65
Cdd:cd07377   3 YEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRG 62
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 7-220 3.30e-16

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 75.19  E-value: 3.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B         7 ESVMDWVTEELRSGRLKIGDHLPSERALSETLGVSRSSLREALRVLEALGTISTATGSGPRSGTIITAAPGQALSLSVTL 86
Cdd:PRK10421   5 DEVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRHETWSEQNIVQPLKT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B        87 QLVTNQVGHHDIYETRQLLEGWAALHSS--AERGDWDVAEALLEKM--DDPSLPledfLRFDAEFHVVISKGAENPLIST 162
Cdd:PRK10421  85 LMADDPDYSFDILEARHAIEASTAWHAAmrATPGDKEKIQLCFEATlsEDPDLA----SQADVRFHLAIAEASHNVVLLQ 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
2DI3_B       163 LMEALrLSVADHTVARARAL----PdwrATSARLQKEHRAILAALRAGESTVAATLIKEHIE 220
Cdd:PRK10421 161 TMRGF-FDVLQSSVKQSRQRmylvP---PVFSQLTEQHQAVMDAILAGDAEGARKAMMAHLS 218
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 97-221 2.07e-15

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 70.08  E-value: 2.07e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B          97 DIYETRQLLEGWAAlHSSAERG---DWDVAEALLEKMD---DPSLPLEDFLRFDAEFHVVISKGAENPLISTLMEALRLS 170
Cdd:smart00895   1 ELYEVRRALEPLAA-RLAAERAtdeDLAALEALLDAMEaaaAAGDDLEEFAELDREFHRALAEAAGNPVLLELLESLRAR 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
2DI3_B         171 VADHTVARARALpdwratsARLQKEHRAILAALRAGESTVAATLIKEHIEG 221
Cdd:smart00895  80 LRRLRRLSLEAA-------RRALDEHRAILDAIRARDAEAARAAMREHLEA 123
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 20-163 1.55e-14

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 70.57  E-value: 1.55e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B        20 GRLKIGDHLPSERALSETLGVSRSSLREALRVLEALGTISTATGSGPRSGTiITAAPGQalslSVTLQLVTNQVGH-HDI 98
Cdd:PRK09990  23 GVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVAR-LNRVQDA----SPLMHLFSSQPRTlYDL 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
2DI3_B        99 YETRQLLEGWAAlHSSAERG---DWDVAEALLEKM-----DDPSLPLEDFLRFDAEFHVVISKGAENP-LISTL 163
Cdd:PRK09990  98 LEVRALLEGESA-RLAALRGtqaDFVLITRRYEEMlaaheNNKEIDPIEHARLDHAFHLAICEASHNPvLVHTL 170
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
9-65 1.64e-12

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 60.67  E-value: 1.64e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
2DI3_B           9 VMDWVTEELRSGRLKIGDHLPSERALSETLGVSRSSLREALRVLEALGTISTATGSG 65
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSG 57
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 7-65 7.22e-12

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 58.78  E-value: 7.22e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
2DI3_B          7 ESVMDWVTEELRSGRLKIGDHLPSERALSETLGVSRSSLREALRVLEALGTISTATGSG 65
Cdd:pfam00392   3 EQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRG 61
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 97-217 1.67e-11

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 59.69  E-value: 1.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B         97 DIYETRQLLEGWAAlHSSAERG---DWDVAEALLEKMD--DPSLPLEDFLRFDAEFHVVISKGAENPLISTLMEALRlsv 171
Cdd:pfam07729   1 ELYELRAALEPLAA-RLAAERAtdeDLAELEALLEALEaaADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLW--- 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
2DI3_B        172 aDHTVARARALPDWRATSARLQKEHRAILAALRAGESTVAATLIKE 217
Cdd:pfam07729  77 -DRLRRLRRLLLSSPGRLRASLEEHRAILDAIRARDPEAARAAMRR 121
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
6-65 4.17e-11

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 60.65  E-value: 4.17e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B        6 HESVMDWVTEELRSGRLKIGDHLPSERALSETLGVSRSSLREALRVLEALGTISTATGSG 65
Cdd:COG2188   7 YLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRG 66
PRK10225 PRK10225
Uxu operon transcriptional regulator;
25-220 1.83e-10

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 59.26  E-value: 1.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B        25 GDHLPSERALSETLGVSRSSLREALRVLEALGTISTATGsgprSGTIITAAPGQALSLSVTLQLVtNQVGHHDIYETRQL 104
Cdd:PRK10225  30 GERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRG----AGIYVLDSSGSHNTDSPDANVC-NDAGPFELLQARQL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B       105 LEG----WAALHSSAErgdwDVAEA----LLEKMDDPSLPLEDFLRFDAEFHVVISKGAENpliSTLMEALRLSVA--DH 174
Cdd:PRK10225 105 LESniaeFAALQATRE----DIVKMrqalQLEERELASSAPGSSESGDMQFHLAIAEATHN---SMLVELFRQSWQwrEN 177

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
2DI3_B       175 T---VARARALPDWRATSARLqKEHRAILAALRAGESTVAATLIKEHIE 220
Cdd:PRK10225 178 NpmwIQLHSHLDDSLYRKEWL-GDHKQILAALIKKDARAAKLAMWQHLE 225
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 1-65 7.92e-10

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 58.30  E-value: 7.92e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
2DI3_B        1 MSVKAHESVMDWVTEELRSGRLKIGDHLPSERALSETLGVSRSSLREALRVLEALGTISTATGSG 65
Cdd:COG1167   9 SSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSG 73
PRK11523 PRK11523
transcriptional regulator ExuR;
13-167 8.74e-10

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 57.16  E-value: 8.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B        13 VTEELRSGRLKIGDHLPSERALSETLGVSRSSLREALRVLEALGTISTATGSGPRsgtIITAAPGQALSLSVTLQLVTnq 92
Cdd:PRK11523  17 LKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIH---VVSNQPRHQQAADNNMEFAN-- 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
2DI3_B        93 VGHHDIYETRQLLEGWAALHSSAERGDWDVAeALLEKMDDPSlpLEDFLR---FDAEFHVVISKGAENPLISTLMEAL 167
Cdd:PRK11523  92 YGPFELLQARQLIESNIAEFAATQVTKQDIM-KLMAIQEQAR--GEDCFRdseWDLQFHVQVALATQNSALAAIVEKM 166
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
20-207 5.57e-08

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 51.95  E-value: 5.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B        20 GRLKIGDHLPSERALSETLGVSRSSLREALRVLEALGTISTATGsgprSGTIITAAPGQALSLSVTLQLVTNQVGHHDIY 99
Cdd:PRK09464  26 GTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQG----GGTFVQSSLWQSFSDPLVELLSDHPESQFDLL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DI3_B       100 ETRQLLEGWAALHsSAERGdwdvAEALLEKMDDPSLPLE---DFLRFDAE------FHVVISKGAENPLISTLMEALRlS 170
Cdd:PRK09464 102 ETRHALEGIAAYY-AALRG----TDEDFERIRECHHAIElaqQSGDLDAEanavmqYQIAVTEAAHNVVLLHLLRCME-P 175

                        170       180       190
                 ....*....|....*....|....*....|....*...
2DI3_B       171 VADHTVARARALPDWRATSARLQKEHRA-ILAALRAGE 207
Cdd:PRK09464 176 MLEQNVRQNFELLYRRREMLPKVSSHRArIFEAIVAGK 213
PRK09764 PRK09764
GntR family transcriptional regulator;
9-65 7.77e-08

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 51.37  E-value: 7.77e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
2DI3_B         9 VMDWVTEELRSGRLKIGDHLPSERALSETLGVSRSSLREALRVLEALGTISTATGSG 65
Cdd:PRK09764  10 IADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSG 66
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 4-76 2.11e-04

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 41.96  E-value: 2.11e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
2DI3_B         4 KAHESVMDWVTEELRSGRLKIGDHLPSERALSETLGVSRSSLREALRVLEALGTISTATgsgpRSGTIITAAP 76
Cdd:PRK15481   5 KTANEIFDSIRQLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQG----RNGTVIRGSP 73
PRK04984 PRK04984
fatty acid metabolism transcriptional regulator FadR;
19-52 8.02e-04

fatty acid metabolism transcriptional regulator FadR;


Pssm-ID: 179909 [Multi-domain]  Cd Length: 239  Bit Score: 39.47  E-value: 8.02e-04
                         10        20        30
                 ....*....|....*....|....*....|....
2DI3_B        19 SGRLKIGDHLPSERALSETLGVSRSSLREALRVL 52
Cdd:PRK04984  22 NNRFPPGSILPAERELSELIGVTRTTLREVLQRL 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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