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Conserved domains on  [gi|116666730|pdb|2ALE|A]
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Chain A, NHP2/L7aE family protein YEL026W

Protein Classification

SNU13 family protein( domain architecture ID 15340004)

SNU13 family protein similar to yeast Snu13p which is a bifunctional yeast protein involved in both messenger RNA splicing as well as ribosomal RNA maturation

Gene Ontology:  GO:0003723|GO:0030490

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SNU13 cd21104
U4/U6.U5 small nuclear ribonucleoprotein SNU13; U4/U6.U5 small nuclear ribonucleoprotein SNU13, ...
 5-126 2.51e-90

U4/U6.U5 small nuclear ribonucleoprotein SNU13; U4/U6.U5 small nuclear ribonucleoprotein SNU13, also known as NHP2-like protein 1 or U4/U6.U5 tri-snRNP 15.5 kDa protein, is a component of the spliceosome B complex, involved in pre-mRNA splicing. It binds to the 5'-stem-loop of U4 snRNA.


:

Pssm-ID: 411046  Cd Length: 122  Bit Score: 257.26  E-value: 2.51e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ALE_A        5 NPKAFPLADAALTQQILDVVQQAANLRQLKKGANEATKTLNRGISEFIIMAADCEPIEILLHLPLLCEDKNVPYVFVPSR 84
Cdd:cd21104   1 NPKAYPLADAQLTQTILDLVQQAANYKQLKKGANEATKTLNRGIAEFIVMAADAEPLEILLHLPLLCEDKNVPYVFVPSK 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
2ALE_A       85 VALGRACGVSRPVIAASITTNDASAIKTQIYAVKDKIETLLI 126
Cdd:cd21104  81 QALGRACGVSRPVIACSVTTNEGSQLKSQIQSLKDAIEKLLI 122
 
Name Accession Description Interval E-value
SNU13 cd21104
U4/U6.U5 small nuclear ribonucleoprotein SNU13; U4/U6.U5 small nuclear ribonucleoprotein SNU13, ...
 5-126 2.51e-90

U4/U6.U5 small nuclear ribonucleoprotein SNU13; U4/U6.U5 small nuclear ribonucleoprotein SNU13, also known as NHP2-like protein 1 or U4/U6.U5 tri-snRNP 15.5 kDa protein, is a component of the spliceosome B complex, involved in pre-mRNA splicing. It binds to the 5'-stem-loop of U4 snRNA.


Pssm-ID: 411046  Cd Length: 122  Bit Score: 257.26  E-value: 2.51e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ALE_A        5 NPKAFPLADAALTQQILDVVQQAANLRQLKKGANEATKTLNRGISEFIIMAADCEPIEILLHLPLLCEDKNVPYVFVPSR 84
Cdd:cd21104   1 NPKAYPLADAQLTQTILDLVQQAANYKQLKKGANEATKTLNRGIAEFIVMAADAEPLEILLHLPLLCEDKNVPYVFVPSK 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
2ALE_A       85 VALGRACGVSRPVIAASITTNDASAIKTQIYAVKDKIETLLI 126
Cdd:cd21104  81 QALGRACGVSRPVIACSVTTNEGSQLKSQIQSLKDAIEKLLI 122
Ribosomal_L7Ae pfam01248
Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; This family includes: Ribosomal L7A from ...
 18-110 1.38e-31

Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118.


Pssm-ID: 426153 [Multi-domain]  Cd Length: 95  Bit Score: 107.68  E-value: 1.38e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ALE_A         18 QQILDVVQQAANLRQLKKGANEATKTLNRGISEFIIMAADCEPIEILLHLPLLCEDKNVPYVFVPSRVALGRACGVSRPV 97
Cdd:pfam01248   1 DAIYEVLKKALKTGKLVLGLKEVTKALERGEAKLVIIAEDCDPEEKVKLIPALCKEKNVPYVKVPSKKELGEACGKKRPV 80

                          90
                  ....*....|...
2ALE_A         98 IAASITTNDASAI 110
Cdd:pfam01248  81 SALAIKDEGDSKI 93
eL8_ribo TIGR03677
ribosomal protein eL8, archaeal form; This model specifically identifies the archaeal version ...
 16-124 5.43e-29

ribosomal protein eL8, archaeal form; This model specifically identifies the archaeal version of the large ribosomal complex protein eL8, previously designated L8 in yeast and L7Ae in the archaea. The family is a narrower version of the pfam01248 model which also recognizes the L30 protein.


Pssm-ID: 188367 [Multi-domain]  Cd Length: 117  Bit Score: 101.76  E-value: 5.43e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ALE_A         16 LTQQILDVVQQAANLRQLKKGANEATKTLNRGISEFIIMAADCEPIEILLHLPLLCEDKNVPYVFVPSRVALGRACGVSR 95
Cdd:TIGR03677  10 LADKALEAVEKARETGKIKKGTNEVTKAVERGIAKLVVIAEDVEPPEIVAHLPALCEEKGIPYIYVKSKEDLGAAAGLEV 89

                          90       100
                  ....*....|....*....|....*....
2ALE_A         96 PVIAASITtnDASAIKTQIYAVKDKIETL 124
Cdd:TIGR03677  90 GAASAAIV--DAGKAEELLKEIIEKVEAL 116
Rpl7Ae COG1358
Ribosomal protein L7Ae or related RNA K-turn-binding protein [Translation, ribosomal structure ...
 18-114 1.81e-17

Ribosomal protein L7Ae or related RNA K-turn-binding protein [Translation, ribosomal structure and biogenesis]; Ribosomal protein L7Ae or related RNA K-turn-binding protein is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 440969 [Multi-domain]  Cd Length: 98  Bit Score: 71.73  E-value: 1.81e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ALE_A       18 QQILDVVQQAANLRQLKKGANEATKTLNRGISEFIIMAADCEPiEILLHLPLLCEDKNVPYVFVPSRVALGRACGVSRPV 97
Cdd:COG1358   1 DKILNLLGLARRAGKLVSGEEQVLKAIRKGKAKLVIIAEDASE-NTKKKLLDLCEEYGVPVVEVGTKEELGKAIGKVGRA 79

                        90
                ....*....|....*..
2ALE_A       98 IAASITTNDASAIKTQI 114
Cdd:COG1358  80 VVAITDEGFAKKLLELL 96
PTZ00222 PTZ00222
60S ribosomal protein L7a; Provisional
 36-117 1.26e-08

60S ribosomal protein L7a; Provisional


Pssm-ID: 140249  Cd Length: 263  Bit Score: 51.62  E-value: 1.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ALE_A        36 GANEATKTLNRGISEFIIMAADCEPIEILLHLPLLCEDKNVPYVFVPSRVALGRACG--VSRPVIAASITTNDASAIKTQ 113
Cdd:PTZ00222 136 GLQEVTRAIEKKQARMVVIANNVDPVELVLWMPNLCRANKIPYAIVKDMARLGDAIGrkTATCVAITDVNAEDEAALKNL 215


                 ....
2ALE_A       114 IYAV 117
Cdd:PTZ00222 216 IRSV 219
 
Name Accession Description Interval E-value
SNU13 cd21104
U4/U6.U5 small nuclear ribonucleoprotein SNU13; U4/U6.U5 small nuclear ribonucleoprotein SNU13, ...
 5-126 2.51e-90

U4/U6.U5 small nuclear ribonucleoprotein SNU13; U4/U6.U5 small nuclear ribonucleoprotein SNU13, also known as NHP2-like protein 1 or U4/U6.U5 tri-snRNP 15.5 kDa protein, is a component of the spliceosome B complex, involved in pre-mRNA splicing. It binds to the 5'-stem-loop of U4 snRNA.


Pssm-ID: 411046  Cd Length: 122  Bit Score: 257.26  E-value: 2.51e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ALE_A        5 NPKAFPLADAALTQQILDVVQQAANLRQLKKGANEATKTLNRGISEFIIMAADCEPIEILLHLPLLCEDKNVPYVFVPSR 84
Cdd:cd21104   1 NPKAYPLADAQLTQTILDLVQQAANYKQLKKGANEATKTLNRGIAEFIVMAADAEPLEILLHLPLLCEDKNVPYVFVPSK 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
2ALE_A       85 VALGRACGVSRPVIAASITTNDASAIKTQIYAVKDKIETLLI 126
Cdd:cd21104  81 QALGRACGVSRPVIACSVTTNEGSQLKSQIQSLKDAIEKLLI 122
Ribosomal_L7Ae pfam01248
Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; This family includes: Ribosomal L7A from ...
 18-110 1.38e-31

Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118.


Pssm-ID: 426153 [Multi-domain]  Cd Length: 95  Bit Score: 107.68  E-value: 1.38e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ALE_A         18 QQILDVVQQAANLRQLKKGANEATKTLNRGISEFIIMAADCEPIEILLHLPLLCEDKNVPYVFVPSRVALGRACGVSRPV 97
Cdd:pfam01248   1 DAIYEVLKKALKTGKLVLGLKEVTKALERGEAKLVIIAEDCDPEEKVKLIPALCKEKNVPYVKVPSKKELGEACGKKRPV 80

                          90
                  ....*....|...
2ALE_A         98 IAASITTNDASAI 110
Cdd:pfam01248  81 SALAIKDEGDSKI 93
eL8_ribo TIGR03677
ribosomal protein eL8, archaeal form; This model specifically identifies the archaeal version ...
 16-124 5.43e-29

ribosomal protein eL8, archaeal form; This model specifically identifies the archaeal version of the large ribosomal complex protein eL8, previously designated L8 in yeast and L7Ae in the archaea. The family is a narrower version of the pfam01248 model which also recognizes the L30 protein.


Pssm-ID: 188367 [Multi-domain]  Cd Length: 117  Bit Score: 101.76  E-value: 5.43e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ALE_A         16 LTQQILDVVQQAANLRQLKKGANEATKTLNRGISEFIIMAADCEPIEILLHLPLLCEDKNVPYVFVPSRVALGRACGVSR 95
Cdd:TIGR03677  10 LADKALEAVEKARETGKIKKGTNEVTKAVERGIAKLVVIAEDVEPPEIVAHLPALCEEKGIPYIYVKSKEDLGAAAGLEV 89

                          90       100
                  ....*....|....*....|....*....
2ALE_A         96 PVIAASITtnDASAIKTQIYAVKDKIETL 124
Cdd:TIGR03677  90 GAASAAIV--DAGKAEELLKEIIEKVEAL 116
Rpl7Ae COG1358
Ribosomal protein L7Ae or related RNA K-turn-binding protein [Translation, ribosomal structure ...
 18-114 1.81e-17

Ribosomal protein L7Ae or related RNA K-turn-binding protein [Translation, ribosomal structure and biogenesis]; Ribosomal protein L7Ae or related RNA K-turn-binding protein is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 440969 [Multi-domain]  Cd Length: 98  Bit Score: 71.73  E-value: 1.81e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ALE_A       18 QQILDVVQQAANLRQLKKGANEATKTLNRGISEFIIMAADCEPiEILLHLPLLCEDKNVPYVFVPSRVALGRACGVSRPV 97
Cdd:COG1358   1 DKILNLLGLARRAGKLVSGEEQVLKAIRKGKAKLVIIAEDASE-NTKKKLLDLCEEYGVPVVEVGTKEELGKAIGKVGRA 79

                        90
                ....*....|....*..
2ALE_A       98 IAASITTNDASAIKTQI 114
Cdd:COG1358  80 VVAITDEGFAKKLLELL 96
PTZ00222 PTZ00222
60S ribosomal protein L7a; Provisional
 36-117 1.26e-08

60S ribosomal protein L7a; Provisional


Pssm-ID: 140249  Cd Length: 263  Bit Score: 51.62  E-value: 1.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ALE_A        36 GANEATKTLNRGISEFIIMAADCEPIEILLHLPLLCEDKNVPYVFVPSRVALGRACG--VSRPVIAASITTNDASAIKTQ 113
Cdd:PTZ00222 136 GLQEVTRAIEKKQARMVVIANNVDPVELVLWMPNLCRANKIPYAIVKDMARLGDAIGrkTATCVAITDVNAEDEAALKNL 215


                 ....
2ALE_A       114 IYAV 117
Cdd:PTZ00222 216 IRSV 219
PTZ00365 PTZ00365
60S ribosomal protein L7Ae-like; Provisional
 33-99 4.05e-07

60S ribosomal protein L7Ae-like; Provisional


Pssm-ID: 240382  Cd Length: 266  Bit Score: 47.15  E-value: 4.05e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
2ALE_A        33 LKKGANEATKTLNRGISEFIIMAADCEPIEILLHLPLLCEDKNVPYVFVPSRVALGRACGV-SRPVIA 99
Cdd:PTZ00365 133 LKYGLNHVTDLVEYKKAKLVVIAHDVDPIELVCFLPALCRKKEVPYCIIKGKSRLGKLVHQkTAAVVA 200
RPL30E COG1911
Ribosomal protein L30E [Translation, ribosomal structure and biogenesis]; Ribosomal protein ...
 36-112 2.56e-05

Ribosomal protein L30E [Translation, ribosomal structure and biogenesis]; Ribosomal protein L30E is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 441515 [Multi-domain]  Cd Length: 97  Bit Score: 40.19  E-value: 2.56e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
2ALE_A       36 GANEATKTLNRGISEFIIMAADCePIEILLHLPLLCEDKNVP-YVFVPSRVALGRACGVSRPVIAASITTNDASAIKT 112
Cdd:COG1911  20 GSKQTIKAIKLGKAKLVILAANC-PPEIREDIEYYAKLSNVPvYVYPGTSVELGALCGKPFRVSALAIIDPGESDILA 96
PRK13602 PRK13602
50S ribosomal protein L7ae-like protein;
22-93 2.92e-04

50S ribosomal protein L7ae-like protein;


Pssm-ID: 184174 [Multi-domain]  Cd Length: 82  Bit Score: 37.07  E-value: 2.92e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
2ALE_A        22 DVVQQAANLrqlKKGANEATKTLNRGISEFIIMAADCEPIeILLHLPLLCEDKNVPYVFVPSRVALGRACGV 93
Cdd:PRK13602   4 EKVSQAKSI---VIGTKQTVKALKRGSVKEVVVAEDADPR-LTEKVEALANEKGVPVSKVDSMKKLGKACGI 71
PRK01018 PRK01018
50S ribosomal protein L30e; Reviewed
 36-107 5.12e-03

50S ribosomal protein L30e; Reviewed


Pssm-ID: 179205 [Multi-domain]  Cd Length: 99  Bit Score: 34.17  E-value: 5.12e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
2ALE_A        36 GANEATKTLNRGISEFIIMAADCePIEILLHLPLLCEDKNVP-YVFVPSRVALGRACGvsRPVIAASITTNDA 107
Cdd:PRK01018  20 GSKRTIKAIKLGKAKLVIVASNC-PKDIKEDIEYYAKLSGIPvYEYEGSSVELGTLCG--KPFTVSALAIVDP 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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