Chain F, Exotoxin A
poly(ADP-ribose) polymerase family protein( domain architecture ID 2436)
poly(ADP-ribose) polymerase family protein similar to Oncorhynchus masou poly [ADP-ribose] polymerase 1, which acts as Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
ADP_ribosyl super family | cl00283 | ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. ... |
24-195 | 2.88e-110 | ||||
ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. Poly(ADP-ribose) polymerases (PARPS 1-3, VPARP, tankyrase) catalyze the addition of up to 100 ADP_ribose units from NAD+. PARPs 1 and 2 are localized in the nucleaus, bind DNA, and are activated by DNA damage. VPARP is part of the vault ribonucleoprotein complex. Tankyrases regulates telomere length in part through poy(ADP_ribosylation) of telomere repeat binding factor 1 (TRF1). Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a carboxyl 40 kDa fragment is still catalytically active. The actual alignment was detected with superfamily member pfam09009: Pssm-ID: 444809 Cd Length: 177 Bit Score: 313.13 E-value: 2.88e-110
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Name | Accession | Description | Interval | E-value | ||||
Exotox-A_cataly | pfam09009 | Exotoxin A catalytic; Members of this family, which are found in prokaryotic exotoxin A, ... |
24-195 | 2.88e-110 | ||||
Exotoxin A catalytic; Members of this family, which are found in prokaryotic exotoxin A, catalyze the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, with subsequent inhibition of protein synthesis. Pssm-ID: 430368 Cd Length: 177 Bit Score: 313.13 E-value: 2.88e-110
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Dipth_tox_like | cd01436 | Mono-ADP-ribosylating toxins catalyze the transfer of ADP_ribose from NAD+ to eukaryotic ... |
39-171 | 5.69e-67 | ||||
Mono-ADP-ribosylating toxins catalyze the transfer of ADP_ribose from NAD+ to eukaryotic Elongation Factor 2, halting protein synthesis. A single molecule of delivered toxin is sufficient to kill a cell. These toxins share mono-ADP-ribosylating activity with a variety of bacterial toxins, such as cholera toxin and pertussis toxin. The structural core is homologous to the poly-ADP ribosylating enzymes such as the PARP enzymes and Tankyrase. Diphtheria toxin is encoded by a lysogenic bacteriophage. Both diphtheria toxin and Pseudomonas aeruginosa exotoxin A are multi-domain proteins. These domains provide a EF2 ADP_ribosylating, receptor-binding, and intracellular trafficking/transmembrane functions . Pssm-ID: 238716 Cd Length: 147 Bit Score: 202.49 E-value: 5.69e-67
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Name | Accession | Description | Interval | E-value | ||||
Exotox-A_cataly | pfam09009 | Exotoxin A catalytic; Members of this family, which are found in prokaryotic exotoxin A, ... |
24-195 | 2.88e-110 | ||||
Exotoxin A catalytic; Members of this family, which are found in prokaryotic exotoxin A, catalyze the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, with subsequent inhibition of protein synthesis. Pssm-ID: 430368 Cd Length: 177 Bit Score: 313.13 E-value: 2.88e-110
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Dipth_tox_like | cd01436 | Mono-ADP-ribosylating toxins catalyze the transfer of ADP_ribose from NAD+ to eukaryotic ... |
39-171 | 5.69e-67 | ||||
Mono-ADP-ribosylating toxins catalyze the transfer of ADP_ribose from NAD+ to eukaryotic Elongation Factor 2, halting protein synthesis. A single molecule of delivered toxin is sufficient to kill a cell. These toxins share mono-ADP-ribosylating activity with a variety of bacterial toxins, such as cholera toxin and pertussis toxin. The structural core is homologous to the poly-ADP ribosylating enzymes such as the PARP enzymes and Tankyrase. Diphtheria toxin is encoded by a lysogenic bacteriophage. Both diphtheria toxin and Pseudomonas aeruginosa exotoxin A are multi-domain proteins. These domains provide a EF2 ADP_ribosylating, receptor-binding, and intracellular trafficking/transmembrane functions . Pssm-ID: 238716 Cd Length: 147 Bit Score: 202.49 E-value: 5.69e-67
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Blast search parameters | ||||
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