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Conserved domains on  [gi|48425849|pdb|1UZP|A]
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Chain A, FIBRILLIN-1

Protein Classification

EGF_CA and TB domain-containing protein( domain architecture ID 10640395)

protein containing domains EGF_CA, and TB

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 64-104 2.57e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 55.36  E-value: 2.57e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
1UZP_A         64 CSNEIGVGVSKASCCC-SLGKAWGTPCEMCPAVNTSEYKILC 104
Cdd:pfam00683   3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
121-153 4.40e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 4.40e-05
                           10        20        30
                   ....*....|....*....|....*....|...
1UZP_A         121 DIDECQELPGLCQGGKCINTFGSFQCRCPTGYY 153
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
2-33 8.69e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 8.69e-05
                           10        20        30
                   ....*....|....*....|....*....|...
1UZP_A           2 DVNECLDPTTCISG-NCVNTPGSYICDCPPDFE 33
Cdd:smart00179   1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 64-104 2.57e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 55.36  E-value: 2.57e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
1UZP_A         64 CSNEIGVGVSKASCCC-SLGKAWGTPCEMCPAVNTSEYKILC 104
Cdd:pfam00683   3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
121-153 4.40e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 4.40e-05
                           10        20        30
                   ....*....|....*....|....*....|...
1UZP_A         121 DIDECQELPGLCQGGKCINTFGSFQCRCPTGYY 153
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
2-33 8.69e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 8.69e-05
                           10        20        30
                   ....*....|....*....|....*....|...
1UZP_A           2 DVNECLDPTTCISG-NCVNTPGSYICDCPPDFE 33
Cdd:smart00179   1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2-34 1.38e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.38e-04
                        10        20        30
                ....*....|....*....|....*....|....
1UZP_A        2 DVNECLDPTTC-ISGNCVNTPGSYICDCPPDFEL 34
Cdd:cd00054   1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 121-154 1.68e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.68e-04
                        10        20        30
                ....*....|....*....|....*....|....
1UZP_A      121 DIDECQELPGLCQGGKCINTFGSFQCRCPTGYYL 154
Cdd:cd00054   1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA pfam07645
Calcium-binding EGF domain;
121-151 4.97e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 4.97e-04
                          10        20        30
                  ....*....|....*....|....*....|..
1UZP_A        121 DIDECQELPGLC-QGGKCINTFGSFQCRCPTG 151
Cdd:pfam07645   1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 64-104 2.57e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 55.36  E-value: 2.57e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
1UZP_A         64 CSNEIGVGVSKASCCC-SLGKAWGTPCEMCPAVNTSEYKILC 104
Cdd:pfam00683   3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
121-153 4.40e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 4.40e-05
                           10        20        30
                   ....*....|....*....|....*....|...
1UZP_A         121 DIDECQELPGLCQGGKCINTFGSFQCRCPTGYY 153
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
2-33 8.69e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 8.69e-05
                           10        20        30
                   ....*....|....*....|....*....|...
1UZP_A           2 DVNECLDPTTCISG-NCVNTPGSYICDCPPDFE 33
Cdd:smart00179   1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2-34 1.38e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.38e-04
                        10        20        30
                ....*....|....*....|....*....|....
1UZP_A        2 DVNECLDPTTC-ISGNCVNTPGSYICDCPPDFEL 34
Cdd:cd00054   1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 121-154 1.68e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.68e-04
                        10        20        30
                ....*....|....*....|....*....|....
1UZP_A      121 DIDECQELPGLCQGGKCINTFGSFQCRCPTGYYL 154
Cdd:cd00054   1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 118-160 2.27e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 40.06  E-value: 2.27e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
1UZP_A      118 ILEDIDECQELPGLCQGGkCINTFGSFQCRCPTGYYLNEDTRV 160
Cdd:cd01475 183 ICVVPDLCATLSHVCQQV-CISTPGSYLCACTEGYALLEDNKT 224
EGF_CA pfam07645
Calcium-binding EGF domain;
121-151 4.97e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 4.97e-04
                          10        20        30
                  ....*....|....*....|....*....|..
1UZP_A        121 DIDECQELPGLC-QGGKCINTFGSFQCRCPTG 151
Cdd:pfam07645   1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF smart00181
Epidermal growth factor-like domain;
5-37 3.27e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 33.64  E-value: 3.27e-03
                           10        20        30
                   ....*....|....*....|....*....|...
1UZP_A           5 ECLDPTTCISGNCVNTPGSYICDCPPDFELNPT 37
Cdd:smart00181   1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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