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Conserved domains on  [gi|48425803|pdb|1UL9|A]
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Chain A, galectin-2

Protein Classification

GLECT domain-containing protein( domain architecture ID 10645088)

GLECT domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
 10-137 1.29e-27

Galectin; Galectin - galactose-binding lectin


:

Pssm-ID: 214596  Cd Length: 128  Bit Score: 99.22  E-value: 1.29e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1UL9_A          10 QVKLQNDFKPESVAAIRSSAFNSKGGTTVfNFLSAGENILLHISIRPGENVIVFNSRLkNGAWGPEERIPyAEKFRPPNP 89
Cdd:smart00276   2 TLPIPGGLKPGQTLTVRGIVLPDAKRFSI-NLLTGGDDIALHFNPRFNENKIVCNSKL-NGSWGSEEREG-GFPFQPGQP 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
1UL9_A          90 -SITVIDHGDRFQIRFDYGTSIYYNKRIKENAA-AIAYNAENSLFSSPVT 137
Cdd:smart00276  79 fDLTIIVQPDHFQIFVNGVHITTFPHRLPLESIdYLSINGDVQLTSVSFE 128
 
Name Accession Description Interval E-value
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
 10-137 1.29e-27

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 99.22  E-value: 1.29e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1UL9_A          10 QVKLQNDFKPESVAAIRSSAFNSKGGTTVfNFLSAGENILLHISIRPGENVIVFNSRLkNGAWGPEERIPyAEKFRPPNP 89
Cdd:smart00276   2 TLPIPGGLKPGQTLTVRGIVLPDAKRFSI-NLLTGGDDIALHFNPRFNENKIVCNSKL-NGSWGSEEREG-GFPFQPGQP 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
1UL9_A          90 -SITVIDHGDRFQIRFDYGTSIYYNKRIKENAA-AIAYNAENSLFSSPVT 137
Cdd:smart00276  79 fDLTIIVQPDHFQIFVNGVHITTFPHRLPLESIdYLSINGDVQLTSVSFE 128
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 10-117 4.31e-21

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 82.68  E-value: 4.31e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1UL9_A       10 QVKLQNDFKPESVAAIRSSAFNSKGGTTVfNFLSAGENILLHISIRPGENVIVFNSRLkNGAWGPEERIPYAEKFRPPNP 89
Cdd:cd00070   3 KLPLPGGLKPGSTLTVKGRVLPNAKRFSI-NLGTGSSDIALHFNPRFDENVIVRNSFL-NGNWGPEERSGGFPFQPGQPF 80

                        90       100
                ....*....|....*....|....*...
1UL9_A       90 SITVIDHGDRFQIRFDYGTSIYYNKRIK 117
Cdd:cd00070  81 ELTILVEEDKFQIFVNGQHFFSFPHRLP 108
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 38-115 1.86e-09

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 52.26  E-value: 1.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1UL9_A         38 VFNFLSAGE---NILLHISIRPGENVIVFNSRLkNGAWGPEERIPYaekfrppNPsitvIDHGDRFQIRFDYGTS---IY 111
Cdd:pfam00337  24 SINLQTGVGpsdDIALHFNPRFDENVIVRNSRQ-NGQWGQEEREGG-------FP----FQPGQPFELTILVGDDhfkIY 91


                  ....
1UL9_A        112 YNKR 115
Cdd:pfam00337  92 VNGQ 95
 
Name Accession Description Interval E-value
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
 10-137 1.29e-27

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 99.22  E-value: 1.29e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1UL9_A          10 QVKLQNDFKPESVAAIRSSAFNSKGGTTVfNFLSAGENILLHISIRPGENVIVFNSRLkNGAWGPEERIPyAEKFRPPNP 89
Cdd:smart00276   2 TLPIPGGLKPGQTLTVRGIVLPDAKRFSI-NLLTGGDDIALHFNPRFNENKIVCNSKL-NGSWGSEEREG-GFPFQPGQP 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
1UL9_A          90 -SITVIDHGDRFQIRFDYGTSIYYNKRIKENAA-AIAYNAENSLFSSPVT 137
Cdd:smart00276  79 fDLTIIVQPDHFQIFVNGVHITTFPHRLPLESIdYLSINGDVQLTSVSFE 128
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 10-117 4.31e-21

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 82.68  E-value: 4.31e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1UL9_A       10 QVKLQNDFKPESVAAIRSSAFNSKGGTTVfNFLSAGENILLHISIRPGENVIVFNSRLkNGAWGPEERIPYAEKFRPPNP 89
Cdd:cd00070   3 KLPLPGGLKPGSTLTVKGRVLPNAKRFSI-NLGTGSSDIALHFNPRFDENVIVRNSFL-NGNWGPEERSGGFPFQPGQPF 80

                        90       100
                ....*....|....*....|....*...
1UL9_A       90 SITVIDHGDRFQIRFDYGTSIYYNKRIK 117
Cdd:cd00070  81 ELTILVEEDKFQIFVNGQHFFSFPHRLP 108
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 38-115 1.86e-09

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 52.26  E-value: 1.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1UL9_A         38 VFNFLSAGE---NILLHISIRPGENVIVFNSRLkNGAWGPEERIPYaekfrppNPsitvIDHGDRFQIRFDYGTS---IY 111
Cdd:pfam00337  24 SINLQTGVGpsdDIALHFNPRFDENVIVRNSRQ-NGQWGQEEREGG-------FP----FQPGQPFELTILVGDDhfkIY 91


                  ....
1UL9_A        112 YNKR 115
Cdd:pfam00337  92 VNGQ 95
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 38-80 2.56e-09

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 51.82  E-value: 2.56e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
1UL9_A          38 VFNFLS-AGENILLHISIRPGENVIVFNSRLkNGAWGPEERIPY 80
Cdd:smart00908  24 SINLQCgPNADIALHFNPRFDEGTIVRNSKQ-NGKWGKEERSGG 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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