NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|494619|pdb|1STF|I]
View 

Chain I, STEFIN B (CYSTATIN B)

Protein Classification

CY domain-containing protein( domain architecture ID 10440427)

CY domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 4-92 1.94e-23

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


:

Pssm-ID: 425431  Cd Length: 92  Bit Score: 85.46  E-value: 1.94e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1STF_I         4 GAPSATQPATAETQHIADQVRSQLEEK-YNKKFPVFKAVSFKSQVVAGTNYFIKVHVGDEDFV-HLRVFQSLP-HENKPL 80
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKtDNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPlLDEKWL 80

                         90
                 ....*....|..
1STF_I        81 TLSNYQTNKAKH 92
Cdd:pfam00031 81 GLCSAQVYKVPW 92
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 4-92 1.94e-23

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 85.46  E-value: 1.94e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1STF_I         4 GAPSATQPATAETQHIADQVRSQLEEK-YNKKFPVFKAVSFKSQVVAGTNYFIKVHVGDEDFV-HLRVFQSLP-HENKPL 80
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKtDNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPlLDEKWL 80

                         90
                 ....*....|..
1STF_I        81 TLSNYQTNKAKH 92
Cdd:pfam00031 81 GLCSAQVYKVPW 92
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 1-63 2.24e-14

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 62.83  E-value: 2.24e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
1STF_I           1 MMSGAPSATQPATAETQHIADQVRSQLEEKYNKKF--PVFKAVSFKSQVVAGTNYFIKVHVGDED 63
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYelRVIKVVSAKSQVVAGTNYYLKVEVGETN 65
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 4-79 3.42e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 59.80  E-value: 3.42e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
1STF_I        4 GAPSATQPATAETQHIADQVRSQLEEKYNKK-FPVFKAVSFKSQVVAGTNYFIKVHVGDEDFVHLRVFQSLPHENKP 79
Cdd:cd00042   1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKyLEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLDCPDCKLL 77
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 4-92 1.94e-23

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 85.46  E-value: 1.94e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1STF_I         4 GAPSATQPATAETQHIADQVRSQLEEK-YNKKFPVFKAVSFKSQVVAGTNYFIKVHVGDEDFV-HLRVFQSLP-HENKPL 80
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKtDNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPlLDEKWL 80

                         90
                 ....*....|..
1STF_I        81 TLSNYQTNKAKH 92
Cdd:pfam00031 81 GLCSAQVYKVPW 92
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 1-63 2.24e-14

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 62.83  E-value: 2.24e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
1STF_I           1 MMSGAPSATQPATAETQHIADQVRSQLEEKYNKKF--PVFKAVSFKSQVVAGTNYFIKVHVGDED 63
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYelRVIKVVSAKSQVVAGTNYYLKVEVGETN 65
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 4-79 3.42e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 59.80  E-value: 3.42e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
1STF_I        4 GAPSATQPATAETQHIADQVRSQLEEKYNKK-FPVFKAVSFKSQVVAGTNYFIKVHVGDEDFVHLRVFQSLPHENKP 79
Cdd:cd00042   1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKyLEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLDCPDCKLL 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH