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Conserved domains on  [gi|159162947|pdb|1RMJ|A]
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Chain A, Insulin-like growth factor binding protein 6

Protein Classification

BM-40/SPARC/osteonectin family protein( domain architecture ID 11082431)

BM-40/SPARC/osteonectin family protein is an extracellular calcium-binding protein containing Kazal-type serine protease inhibitor/follistatin-like, EF-hand, and thyroglobulin type-1 repeat domains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 30-101 9.07e-21

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


:

Pssm-ID: 459665  Cd Length: 66  Bit Score: 78.50  E-value: 9.07e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
1RMJ_A         30 CRRHLDSVLQQLQTevYRGAQTLYVPNCDHRGFYRKRQCRSSQGQrrgpCWCVDRMGKSLPGSPDGNGSSSC 101
Cdd:pfam00086   1 CERERARALEQAAS--GRPASGLYIPNCDEDGFYKPVQCHGSTGY----CWCVDPEGQEIPGTRTRGGDPDC 66
 
Name Accession Description Interval E-value
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 30-101 9.07e-21

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 78.50  E-value: 9.07e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
1RMJ_A         30 CRRHLDSVLQQLQTevYRGAQTLYVPNCDHRGFYRKRQCRSSQGQrrgpCWCVDRMGKSLPGSPDGNGSSSC 101
Cdd:pfam00086   1 CERERARALEQAAS--GRPASGLYIPNCDEDGFYKPVQCHGSTGY----CWCVDPEGQEIPGTRTRGGDPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 29-101 1.69e-18

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 72.50  E-value: 1.69e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
1RMJ_A       29 PCRRHLDSVLQQLQTEVYRGaqtLYVPNCDHRGFYRKRQCRSSQGQrrgpCWCVDRMGKSLPGSPDGNGSSSC 101
Cdd:cd00191   1 PCERERASALESLAGPKLSG---LYVPQCDEDGNYEPVQCHGSTGY----CWCVDPDGEEIPGTRTRGGPPNC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 54-103 1.10e-12

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 57.39  E-value: 1.10e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
1RMJ_A          54 VPNCDHRGFYRKRQCRSSQGQrrgpCWCVDRMGKSLPGSPDGNGSSSCPT 103
Cdd:smart00211   1 IPQCDEDGNYEPVQCDGSSGQ----CWCVDATGREIPGTRTEGGDPDCPS 46
 
Name Accession Description Interval E-value
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 30-101 9.07e-21

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 78.50  E-value: 9.07e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
1RMJ_A         30 CRRHLDSVLQQLQTevYRGAQTLYVPNCDHRGFYRKRQCRSSQGQrrgpCWCVDRMGKSLPGSPDGNGSSSC 101
Cdd:pfam00086   1 CERERARALEQAAS--GRPASGLYIPNCDEDGFYKPVQCHGSTGY----CWCVDPEGQEIPGTRTRGGDPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 29-101 1.69e-18

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 72.50  E-value: 1.69e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
1RMJ_A       29 PCRRHLDSVLQQLQTEVYRGaqtLYVPNCDHRGFYRKRQCRSSQGQrrgpCWCVDRMGKSLPGSPDGNGSSSC 101
Cdd:cd00191   1 PCERERASALESLAGPKLSG---LYVPQCDEDGNYEPVQCHGSTGY----CWCVDPDGEEIPGTRTRGGPPNC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 54-103 1.10e-12

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 57.39  E-value: 1.10e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
1RMJ_A          54 VPNCDHRGFYRKRQCRSSQGQrrgpCWCVDRMGKSLPGSPDGNGSSSCPT 103
Cdd:smart00211   1 IPQCDEDGNYEPVQCDGSSGQ----CWCVDATGREIPGTRTEGGDPDCPS 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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