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Conserved domains on  [gi|157831885|pdb|1LSP|A]
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Chain A, LYSOZYME

Protein Classification

lysozyme family protein; bifunctional lytic transglycosylase/C40 family peptidase( domain architecture ID 10099091)

lysozyme family protein| bifunctional lytic transglycosylase/C40 family peptidase may catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), and/or cleave peptide cross-bridges between glycan chains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GEWL cd01021
Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; ...
 12-184 1.05e-109

Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; GEWL) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc). Mammals have two lysozymes. This family corresponds to human and mouse lysozyme G-like protein 2.


:

Pssm-ID: 381601 [Multi-domain]  Cd Length: 174  Bit Score: 310.30  E-value: 1.05e-109
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LSP_A       12 DTTGASCKTAKPEGLSYCGVPASKTIAERDLKAMDRYKTIIKKVGEKLCVEPAVIAGIISRESHAGKVL-KNGWGDRGNG 90
Cdd:cd01021   1 ETTGASAATAKQDGLLYGGVAASEKMAETDLNRLNKYKDCIKQVGKKLCIDPALIAAIISRESRAGAALdKNGWGDHGNG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LSP_A       91 FGLMQVDKRSHKPQGTWNGEVHITQGTTILTDFIKRIQKKFPSWTKDQQLKGGISAYNAGAGNVRSYARMDIGTTHDDYA 170
Cdd:cd01021  81 FGLMQVDKRYHPPKGAWDSEEHIEQATGILIDFIKTVQRKHPSWSPEQQLKGGIAAYNAGVGNVQSYAGMDIGTTGNDYS 160

                       170
                ....*....|....
1LSP_A      171 NDVVARAQYYKQHG 184
Cdd:cd01021 161 NDVIARAQWYKNNG 174
 
Name Accession Description Interval E-value
GEWL cd01021
Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; ...
 12-184 1.05e-109

Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; GEWL) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc). Mammals have two lysozymes. This family corresponds to human and mouse lysozyme G-like protein 2.


Pssm-ID: 381601 [Multi-domain]  Cd Length: 174  Bit Score: 310.30  E-value: 1.05e-109
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LSP_A       12 DTTGASCKTAKPEGLSYCGVPASKTIAERDLKAMDRYKTIIKKVGEKLCVEPAVIAGIISRESHAGKVL-KNGWGDRGNG 90
Cdd:cd01021   1 ETTGASAATAKQDGLLYGGVAASEKMAETDLNRLNKYKDCIKQVGKKLCIDPALIAAIISRESRAGAALdKNGWGDHGNG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LSP_A       91 FGLMQVDKRSHKPQGTWNGEVHITQGTTILTDFIKRIQKKFPSWTKDQQLKGGISAYNAGAGNVRSYARMDIGTTHDDYA 170
Cdd:cd01021  81 FGLMQVDKRYHPPKGAWDSEEHIEQATGILIDFIKTVQRKHPSWSPEQQLKGGIAAYNAGVGNVQSYAGMDIGTTGNDYS 160

                       170
                ....*....|....
1LSP_A      171 NDVVARAQYYKQHG 184
Cdd:cd01021 161 NDVIARAQWYKNNG 174
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 31-159 5.46e-06

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 45.37  E-value: 5.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LSP_A       31 VPASKTIAERDLKAMDRYKTIIKKVGEKLCVEPAVIAGIISRES--------HAGKVlkngwgdrgngfGLMQV------ 96
Cdd:COG0741  86 AAELLALAALLLRRPLPYLPLIEEAAKKYGVDPALVLALIRQESafnpnavsPAGAR------------GLMQLmpatar 153

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
1LSP_A       97 -----DKRSHKPQGTWNGEVHITQGTTILtdfiKRIQKKFpswtkDQQLKGGISAYNAGAGNVRSYAR 159
Cdd:COG0741 154 rlglkLGLGPSPDDLFDPETNIRAGAAYL----RELLDRF-----DGDLVLALAAYNAGPGRVRRWLR 212
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 52-157 3.67e-04

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 38.44  E-value: 3.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LSP_A         52 IKKVGEKLCVEPAVIAGIISRESHAGKVLKNGWGDRGngfgLMQ---------VDKRSHKPQGTWNGEVHITQGTTILTD 122
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVG----LMQimpstakrlGLRVNPGVDDLFDPEKNIKAGTKYLKE 76

                          90       100       110
                  ....*....|....*....|....*....|....*
1LSP_A        123 FIKRIqkkfpswtkDQQLKGGISAYNAGAGNVRSY 157
Cdd:pfam01464  77 LYKQY---------GGDLWLALAAYNAGPGRVRKW 102
 
Name Accession Description Interval E-value
GEWL cd01021
Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; ...
 12-184 1.05e-109

Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; GEWL) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc). Mammals have two lysozymes. This family corresponds to human and mouse lysozyme G-like protein 2.


Pssm-ID: 381601 [Multi-domain]  Cd Length: 174  Bit Score: 310.30  E-value: 1.05e-109
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LSP_A       12 DTTGASCKTAKPEGLSYCGVPASKTIAERDLKAMDRYKTIIKKVGEKLCVEPAVIAGIISRESHAGKVL-KNGWGDRGNG 90
Cdd:cd01021   1 ETTGASAATAKQDGLLYGGVAASEKMAETDLNRLNKYKDCIKQVGKKLCIDPALIAAIISRESRAGAALdKNGWGDHGNG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LSP_A       91 FGLMQVDKRSHKPQGTWNGEVHITQGTTILTDFIKRIQKKFPSWTKDQQLKGGISAYNAGAGNVRSYARMDIGTTHDDYA 170
Cdd:cd01021  81 FGLMQVDKRYHPPKGAWDSEEHIEQATGILIDFIKTVQRKHPSWSPEQQLKGGIAAYNAGVGNVQSYAGMDIGTTGNDYS 160

                       170
                ....*....|....
1LSP_A      171 NDVVARAQYYKQHG 184
Cdd:cd01021 161 NDVIARAQWYKNNG 174
lyz_G-like_1 cd16888
lysozyme G-like protein 1; Eukaryotic goose-type or G-type lysozymes (goose egg-white lysozyme; ...
 18-185 2.95e-49

lysozyme G-like protein 1; Eukaryotic goose-type or G-type lysozymes (goose egg-white lysozyme; GEWL) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc). Mammals have two lysozyme G-like proteins, and this family corresponds to human and mouse lysozyme G-like protein 1. In humans and some other species, the canonical catalytic glutamate residue is absent, suggesting a loss of muramidase activity.


Pssm-ID: 381609  Cd Length: 160  Bit Score: 157.00  E-value: 2.95e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LSP_A       18 CKTAKPEGLSYCGVPASKTIAERDLKAMDRYKTIIKKVGEKLCVEPAVIAGIISRESHAGKVLKNGwGDRGNGFGLMQvd 97
Cdd:cd16888   1 CRIGRRHGLNYCGVRASERLAEIDMPYLLRYQPMMRTVGQKYCMDPAVIAGVLSRESPGGNYLVDL-GNVGDGLGMVQ-- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LSP_A       98 KRSHKPQGTWNGEVHITQGTTILTDFIKRIQKKFPSWTKDQQLKGGISAYNAGAGNVRSyaRMDIGTthdDYANDVVARA 177
Cdd:cd16888  78 DTGFYAPTSWISESQVSQKTEVLTSRIKEIQRRFPTWTPDQCLRGGLCAYSGGPGYVRS--NQDLSC---DFCNDVLARA 152


                ....*...
1LSP_A      178 QYYKQHGY 185
Cdd:cd16888 153 KYFKRHGF 160
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 31-159 5.46e-06

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 45.37  E-value: 5.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LSP_A       31 VPASKTIAERDLKAMDRYKTIIKKVGEKLCVEPAVIAGIISRES--------HAGKVlkngwgdrgngfGLMQV------ 96
Cdd:COG0741  86 AAELLALAALLLRRPLPYLPLIEEAAKKYGVDPALVLALIRQESafnpnavsPAGAR------------GLMQLmpatar 153

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
1LSP_A       97 -----DKRSHKPQGTWNGEVHITQGTTILtdfiKRIQKKFpswtkDQQLKGGISAYNAGAGNVRSYAR 159
Cdd:COG0741 154 rlglkLGLGPSPDDLFDPETNIRAGAAYL----RELLDRF-----DGDLVLALAAYNAGPGRVRRWLR 212
Lyz-like cd00442
lysozyme-like domains; This family contains several members, including soluble lytic ...
 65-119 5.85e-06

lysozyme-like domains; This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.


Pssm-ID: 381596 [Multi-domain]  Cd Length: 59  Bit Score: 42.01  E-value: 5.85e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
1LSP_A       65 VIAGIISRESHAGKVLknGWGDRGNGFGLMQVDKRSHK------PQGTWNGEVHITQGTTI 119
Cdd:cd00442   1 VLAAIIGQESGGNKPA--NAGSGSGAAGLFQFMPGTWKaygknsSSDLNDPEASIEAAAKY 59
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 48-155 2.03e-04

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 39.77  E-value: 2.03e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LSP_A       48 YKTIIKKVGEKLCVEPAVIAGIISRE--------SHAGKVlkngwgdrgngfGLMQV------------DKRSHKPQGTW 107
Cdd:cd13401   6 YRDLVERAAKKNGLDPALVYAIIRQEsafdpdavSPAGAL------------GLMQLmpatakdvakklGLPYYSPRDLF 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
1LSP_A      108 NGEVHITQGTTiltdFIKRIQKKFpswtkDQQLKGGISAYNAGAGNVR 155
Cdd:cd13401  74 DPEYNIRLGSA----YLAELLDRF-----DGNPVLALAAYNAGPGRVR 112
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 52-157 3.67e-04

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 38.44  E-value: 3.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LSP_A         52 IKKVGEKLCVEPAVIAGIISRESHAGKVLKNGWGDRGngfgLMQ---------VDKRSHKPQGTWNGEVHITQGTTILTD 122
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVG----LMQimpstakrlGLRVNPGVDDLFDPEKNIKAGTKYLKE 76

                          90       100       110
                  ....*....|....*....|....*....|....*
1LSP_A        123 FIKRIqkkfpswtkDQQLKGGISAYNAGAGNVRSY 157
Cdd:pfam01464  77 LYKQY---------GGDLWLALAAYNAGPGRVRKW 102
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 63-178 5.02e-04

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 37.96  E-value: 5.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LSP_A       63 PAVIAGIISRESHAGKVLKNGWGDRGngfgLMQV------DKRSHKPQGTWNGEVHITQGTTILTDFIKRiqkkfpswtK 136
Cdd:cd00254   1 PALVLAVIRVESGFNPRAVSPAGARG----LMQLmpgtarDLGRRGVDDLFDPEENIRAGARYLRELLDR---------F 67

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
1LSP_A      137 DQQLKGGISAYNAGAGNVRSYARMDI----GTTHddYANDVVARAQ 178
Cdd:cd00254  68 GGDLELALAAYNAGPGAVDRWGGGEVppykETRN--YVQRVLAYYQ 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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