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Conserved domains on  [gi|1127256|pdb|1LCP|A]
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Chain A, LEUCINE AMINOPEPTIDASE

Protein Classification

M17 family metallopeptidase( domain architecture ID 10087321)

M17 family metallopeptidase such as leucine aminopeptidase that catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

EC:  3.4.11.-
Gene Ontology:  GO:0046872|GO:0070006|GO:0006508
MEROPS:  M17
SCOP:  4000505|4000584

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Peptidase_M17 cd00433
Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- ...
1-479 0e+00

Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and play a key role in protein degradation and in the metabolism of biologically active peptides. They do not contain HEXXH motif (which is used as one of the signature patterns to group the peptidase families) in the metal-binding site. The two associated zinc ions and the active site are entirely enclosed within the C-terminal catalytic domain in leucine aminopeptidase. The enzyme is a hexamer, with the catalytic domains clustered around the three-fold axis, and the two trimers related to one another by a two-fold rotation. The N-terminal domain is structurally similar to the ADP-ribose binding Macro domain. This family includes proteins from bacteria, archaea, animals and plants.


:

Pssm-ID: 238247 [Multi-domain]  Cd Length: 468  Bit Score: 628.81  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A        1 TKGLVLGIYskekeEDEPQFTSAGENFNKLVSGKLREILNISGPPLKAGKTRTFYGLHEDFPSVVVVGLGKKTAgideqe 80
Cdd:cd00433   1 ADGLVLGVF-----EGEGGLPPAAEKLDAASSGALAALLKASGFKGKAGETLLLPALGGGAKRVALVGLGKEED------ 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A       81 nwhEGKENIRAAVAAGCRQIQDLEIPSVEVDPCG---DAQAAAEGAVLGLYEYDDLKQKRK----VVVSAKLHGSEDQEA 153
Cdd:cd00433  70 ---LDVENLRKAAGAAARALKKLGSKSVAVDLPTlaeDAEAAAEGALLGAYRFDRYKSKKKktplLVVLELGNDKAAEAA 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A      154 WQRGVLFASGQNLARRLMETPANEMTPTKFAEIVEENLKSASIKtdVFIRPKSWIEEQEMGSFLSVAKGSEEPPVFLEIH 233
Cdd:cd00433 147 LERGEAIAEGVNLARDLVNTPANDLTPTYLAEEAKELAKELGVK--VEVLDEKELEELGMGALLAVGKGSEEPPRLIVLE 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A      234 YKGsPNASEPPLVFVGKGITFDSGGISIKAAANMDLMRADMGGAATICSAIVSAAKLDLPINIVGLAPLCENMPSGKANK 313
Cdd:cd00433 225 YKG-KGASKKPIALVGKGITFDTGGLSLKPAAGMDGMKYDMGGAAAVLGAMKAIAELKLPVNVVGVLPLAENMISGNAYR 303
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A      314 PGDVVRARNGKTIQVDNTDAEGRLILADALCYAHTFNPKVIINAATLTGAMDIALGSGATGVFTNSSWLWNKLFEASIET 393
Cdd:cd00433 304 PGDVITSRSGKTVEILNTDAEGRLVLADALTYAQEFKPDLIIDIATLTGAAVVALGHDYAGLFTNDDELAKQLLAAGEAS 383
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A      394 GDRVWRMPLFEHYTRQvIDCQLADVNNIGKYRSAGACTAAAFLKEFVTHP-KWAHLDIAGVMTNKDEvPYLRKGMAGRPT 472
Cdd:cd00433 384 GERVWRLPLWEEYREQ-LKSDIADLKNIGGRGPAGSITAALFLKEFVGDGiPWAHLDIAGTAWKSKP-GYLPKGATGFGV 461

                ....*..
1LCP_A      473 RTLIEFL 479
Cdd:cd00433 462 RLLVEFL 468
 
Name Accession Description Interval E-value
Peptidase_M17 cd00433
Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- ...
1-479 0e+00

Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and play a key role in protein degradation and in the metabolism of biologically active peptides. They do not contain HEXXH motif (which is used as one of the signature patterns to group the peptidase families) in the metal-binding site. The two associated zinc ions and the active site are entirely enclosed within the C-terminal catalytic domain in leucine aminopeptidase. The enzyme is a hexamer, with the catalytic domains clustered around the three-fold axis, and the two trimers related to one another by a two-fold rotation. The N-terminal domain is structurally similar to the ADP-ribose binding Macro domain. This family includes proteins from bacteria, archaea, animals and plants.


Pssm-ID: 238247 [Multi-domain]  Cd Length: 468  Bit Score: 628.81  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A        1 TKGLVLGIYskekeEDEPQFTSAGENFNKLVSGKLREILNISGPPLKAGKTRTFYGLHEDFPSVVVVGLGKKTAgideqe 80
Cdd:cd00433   1 ADGLVLGVF-----EGEGGLPPAAEKLDAASSGALAALLKASGFKGKAGETLLLPALGGGAKRVALVGLGKEED------ 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A       81 nwhEGKENIRAAVAAGCRQIQDLEIPSVEVDPCG---DAQAAAEGAVLGLYEYDDLKQKRK----VVVSAKLHGSEDQEA 153
Cdd:cd00433  70 ---LDVENLRKAAGAAARALKKLGSKSVAVDLPTlaeDAEAAAEGALLGAYRFDRYKSKKKktplLVVLELGNDKAAEAA 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A      154 WQRGVLFASGQNLARRLMETPANEMTPTKFAEIVEENLKSASIKtdVFIRPKSWIEEQEMGSFLSVAKGSEEPPVFLEIH 233
Cdd:cd00433 147 LERGEAIAEGVNLARDLVNTPANDLTPTYLAEEAKELAKELGVK--VEVLDEKELEELGMGALLAVGKGSEEPPRLIVLE 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A      234 YKGsPNASEPPLVFVGKGITFDSGGISIKAAANMDLMRADMGGAATICSAIVSAAKLDLPINIVGLAPLCENMPSGKANK 313
Cdd:cd00433 225 YKG-KGASKKPIALVGKGITFDTGGLSLKPAAGMDGMKYDMGGAAAVLGAMKAIAELKLPVNVVGVLPLAENMISGNAYR 303
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A      314 PGDVVRARNGKTIQVDNTDAEGRLILADALCYAHTFNPKVIINAATLTGAMDIALGSGATGVFTNSSWLWNKLFEASIET 393
Cdd:cd00433 304 PGDVITSRSGKTVEILNTDAEGRLVLADALTYAQEFKPDLIIDIATLTGAAVVALGHDYAGLFTNDDELAKQLLAAGEAS 383
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A      394 GDRVWRMPLFEHYTRQvIDCQLADVNNIGKYRSAGACTAAAFLKEFVTHP-KWAHLDIAGVMTNKDEvPYLRKGMAGRPT 472
Cdd:cd00433 384 GERVWRLPLWEEYREQ-LKSDIADLKNIGGRGPAGSITAALFLKEFVGDGiPWAHLDIAGTAWKSKP-GYLPKGATGFGV 461

                ....*..
1LCP_A      473 RTLIEFL 479
Cdd:cd00433 462 RLLVEFL 468
PepB COG0260
Leucyl aminopeptidase [Amino acid transport and metabolism];
4-484 0e+00

Leucyl aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 440030 [Multi-domain]  Cd Length: 492  Bit Score: 517.36  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A        4 LVLGIYSKEKeedepqFTSAGENFNKLVSGKLREILNISGPPLKAGKTRTFYGL-HEDFPSVVVVGLGKKtAGIDEqenw 82
Cdd:COG0260  18 LVVGVFEGGD------LSPAAAALDAALGGALAALLAAGGFKGKAGETLLLPGPpGLAAERVVLVGLGKA-EELDA---- 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A       83 hegkENIRAAVAAGCRQIQDLEIPSVEV------DPCGDAQAAAEGAVLGLYEYDDLKQKRK--------VVVSAKLhgS 148
Cdd:COG0260  87 ----EDLRKAAAAAARALKKAGAKSVAValpelpDDAEAAEAAAEGALLGAYRFDRYKSKKKepppleelTLVVPDA--A 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A      149 EDQEAWQRGVLFASGQNLARRLMETPANEMTPTKFAEIVEENLKSASIKTDVFIRPKswIEEQEMGSFLSVAKGSEEPPV 228
Cdd:COG0260 161 AAEAALARAEAIAEGVNLARDLVNTPANDLTPEELAERAKELAKEHGLKVEVLDEKE--LEKLGMGALLAVGQGSARPPR 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A      229 FLEIHYKGsPNASEPPLVFVGKGITFDSGGISIKAAANMDLMRADMGGAATICSAIVSAAKLDLPINIVGLAPLCENMPS 308
Cdd:COG0260 239 LIVLEYKG-GGKAKPPVALVGKGVTFDTGGISLKPAAGMEEMKKDMGGAAAVLGAMKAIAELKLPVNVVGLIPAVENMPS 317
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A      309 GKANKPGDVVRARNGKTIQVDNTDAEGRLILADALCYAH-TFNPKVIINAATLTGAMDIALGSGATGVFTNSSWLWNKLF 387
Cdd:COG0260 318 GNAYRPGDVLTSMSGKTVEVLNTDAEGRLVLADALTYAAeRFKPDLIIDLATLTGACVVALGPDTAGLFSNDDALADELL 397
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A      388 EASIETGDRVWRMPLFEHYTRQvIDCQLADVNNIGKyRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGM 467
Cdd:COG0260 398 AAGEAAGEPVWRLPLWDEYREQ-LKSDIADLKNIGG-RFAGAITAALFLRRFVGDTPWAHLDIAGTAWNSGARPYRPKGA 475
                       490
                ....*....|....*..
1LCP_A      468 AGRPTRTLIEFLFRFSQ 484
Cdd:COG0260 476 TGFGVRLLVELLEDRAE 492
PRK00913 PRK00913
multifunctional aminopeptidase A; Provisional
4-479 5.76e-176

multifunctional aminopeptidase A; Provisional


Pssm-ID: 234863 [Multi-domain]  Cd Length: 483  Bit Score: 502.77  E-value: 5.76e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A         4 LVLGIYSKekeedepqFTSAGENFNKLVSGKLREILNISGPPLKAGKTRTFYGL-HEDFPSVVVVGLGKKTAgIDEqenw 82
Cdd:PRK00913  18 LVVGVPER--------LSPAAEQLDKASDGYLSALLKRGDFKGKAGETLLLHAVpGVLAERVLLVGLGKEEE-LDE---- 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A        83 hegkENIRAAVAAGCRQIQDLEIPSV-----EVDPCGDAQAAAEGAVLGLYEYDDLKQK-------RKVVVSAKLHGSED 150
Cdd:PRK00913  85 ----EQLRKAAGKAARALKKTKVKEAvifltELHTYWKARAAAEGALLGLYRFDKYKSKkeprrplEKLVFLVPTRLTEA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A       151 QEAWQRGVLFASGQNLARRLMETPANEMTPTKFAEIVEENLKSASIKTDVFirPKSWIEEQEMGSFLSVAKGSEEPPVFL 230
Cdd:PRK00913 161 EKAIAHGEAIAEGVNLARDLVNEPPNILTPAYLAERAKELAKEYGLEVEVL--DEKEMEKLGMGALLAVGQGSANPPRLI 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A       231 EIHYKGSPnasePPLVFVGKGITFDSGGISIKAAANMDLMRADMGGAATICSAIVSAAKLDLPINIVGLAPLCENMPSGK 310
Cdd:PRK00913 239 VLEYKGGK----KPIALVGKGLTFDSGGISLKPAAGMDEMKYDMGGAAAVLGTMRALAELKLPVNVVGVVAACENMPSGN 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A       311 ANKPGDVVRARNGKTIQVDNTDAEGRLILADALCYAHTFNPKVIINAATLTGAMDIALGSGATGVFTNSSWLWNKLFEAS 390
Cdd:PRK00913 315 AYRPGDVLTSMSGKTIEVLNTDAEGRLVLADALTYAERFKPDAIIDVATLTGACVVALGHHTAGLMSNNDELADELLKAG 394
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A       391 IETGDRVWRMPLFEHYTRQvIDCQLADVNNIGKyRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGMAGR 470
Cdd:PRK00913 395 EESGERAWRLPLGDEYQEQ-LKSPFADMANIGG-RPGGAITAACFLSRFVEKYPWAHLDIAGTAWNSKAWGYNPKGATGR 472

                 ....*....
1LCP_A       471 PTRTLIEFL 479
Cdd:PRK00913 473 GVRLLVQFL 481
Peptidase_M17 pfam00883
Cytosol aminopeptidase family, catalytic domain; The two associated zinc ions and the active ...
166-474 5.31e-175

Cytosol aminopeptidase family, catalytic domain; The two associated zinc ions and the active site are entirely enclosed within the C-terminal catalytic domain in leucine aminopeptidase.


Pssm-ID: 459978  Cd Length: 304  Bit Score: 493.05  E-value: 5.31e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A        166 LARRLMETPANEMTPTKFAEIVEEnLKSASIKTDVFIRPKSWIEEQEMGSFLSVAKGSEEPPVFLEIHYKGSPNAsEPPL 245
Cdd:pfam00883   1 LARDLVNTPANVLTPETFAEAAKE-LAKEYGGVKVEVLDEEELEELGMGAFLAVGKGSEEPPRLVVLEYKGAGPD-DKPI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A        246 VFVGKGITFDSGGISIKAAANMDLMRADMGGAATICSAIVSAAKLDLPINIVGLAPLCENMPSGKANKPGDVVRARNGKT 325
Cdd:pfam00883  79 ALVGKGITFDSGGISLKPAAGMEEMKGDMGGAAAVLGAMRAIAALKLPVNVVAVLPLAENMPSGNAYKPGDVITSMNGKT 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A        326 IQVDNTDAEGRLILADALCYAHTFNPKVIINAATLTGAMDIALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEH 405
Cdd:pfam00883 159 VEVLNTDAEGRLVLADALTYAEKFKPDLIIDVATLTGACVVALGEDYAGLFSNDDELAEELLAAGEATGERVWRLPLWEE 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
1LCP_A        406 YTRQvIDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYlrKGMAGRPTRT 474
Cdd:pfam00883 239 YREQ-LKSDVADLKNVGGGGRAGAITAAAFLKEFVEDTPWAHLDIAGTAWKDDGGGK--KGATGRGVRT 304
 
Name Accession Description Interval E-value
Peptidase_M17 cd00433
Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- ...
1-479 0e+00

Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and play a key role in protein degradation and in the metabolism of biologically active peptides. They do not contain HEXXH motif (which is used as one of the signature patterns to group the peptidase families) in the metal-binding site. The two associated zinc ions and the active site are entirely enclosed within the C-terminal catalytic domain in leucine aminopeptidase. The enzyme is a hexamer, with the catalytic domains clustered around the three-fold axis, and the two trimers related to one another by a two-fold rotation. The N-terminal domain is structurally similar to the ADP-ribose binding Macro domain. This family includes proteins from bacteria, archaea, animals and plants.


Pssm-ID: 238247 [Multi-domain]  Cd Length: 468  Bit Score: 628.81  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A        1 TKGLVLGIYskekeEDEPQFTSAGENFNKLVSGKLREILNISGPPLKAGKTRTFYGLHEDFPSVVVVGLGKKTAgideqe 80
Cdd:cd00433   1 ADGLVLGVF-----EGEGGLPPAAEKLDAASSGALAALLKASGFKGKAGETLLLPALGGGAKRVALVGLGKEED------ 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A       81 nwhEGKENIRAAVAAGCRQIQDLEIPSVEVDPCG---DAQAAAEGAVLGLYEYDDLKQKRK----VVVSAKLHGSEDQEA 153
Cdd:cd00433  70 ---LDVENLRKAAGAAARALKKLGSKSVAVDLPTlaeDAEAAAEGALLGAYRFDRYKSKKKktplLVVLELGNDKAAEAA 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A      154 WQRGVLFASGQNLARRLMETPANEMTPTKFAEIVEENLKSASIKtdVFIRPKSWIEEQEMGSFLSVAKGSEEPPVFLEIH 233
Cdd:cd00433 147 LERGEAIAEGVNLARDLVNTPANDLTPTYLAEEAKELAKELGVK--VEVLDEKELEELGMGALLAVGKGSEEPPRLIVLE 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A      234 YKGsPNASEPPLVFVGKGITFDSGGISIKAAANMDLMRADMGGAATICSAIVSAAKLDLPINIVGLAPLCENMPSGKANK 313
Cdd:cd00433 225 YKG-KGASKKPIALVGKGITFDTGGLSLKPAAGMDGMKYDMGGAAAVLGAMKAIAELKLPVNVVGVLPLAENMISGNAYR 303
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A      314 PGDVVRARNGKTIQVDNTDAEGRLILADALCYAHTFNPKVIINAATLTGAMDIALGSGATGVFTNSSWLWNKLFEASIET 393
Cdd:cd00433 304 PGDVITSRSGKTVEILNTDAEGRLVLADALTYAQEFKPDLIIDIATLTGAAVVALGHDYAGLFTNDDELAKQLLAAGEAS 383
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A      394 GDRVWRMPLFEHYTRQvIDCQLADVNNIGKYRSAGACTAAAFLKEFVTHP-KWAHLDIAGVMTNKDEvPYLRKGMAGRPT 472
Cdd:cd00433 384 GERVWRLPLWEEYREQ-LKSDIADLKNIGGRGPAGSITAALFLKEFVGDGiPWAHLDIAGTAWKSKP-GYLPKGATGFGV 461

                ....*..
1LCP_A      473 RTLIEFL 479
Cdd:cd00433 462 RLLVEFL 468
PepB COG0260
Leucyl aminopeptidase [Amino acid transport and metabolism];
4-484 0e+00

Leucyl aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 440030 [Multi-domain]  Cd Length: 492  Bit Score: 517.36  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A        4 LVLGIYSKEKeedepqFTSAGENFNKLVSGKLREILNISGPPLKAGKTRTFYGL-HEDFPSVVVVGLGKKtAGIDEqenw 82
Cdd:COG0260  18 LVVGVFEGGD------LSPAAAALDAALGGALAALLAAGGFKGKAGETLLLPGPpGLAAERVVLVGLGKA-EELDA---- 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A       83 hegkENIRAAVAAGCRQIQDLEIPSVEV------DPCGDAQAAAEGAVLGLYEYDDLKQKRK--------VVVSAKLhgS 148
Cdd:COG0260  87 ----EDLRKAAAAAARALKKAGAKSVAValpelpDDAEAAEAAAEGALLGAYRFDRYKSKKKepppleelTLVVPDA--A 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A      149 EDQEAWQRGVLFASGQNLARRLMETPANEMTPTKFAEIVEENLKSASIKTDVFIRPKswIEEQEMGSFLSVAKGSEEPPV 228
Cdd:COG0260 161 AAEAALARAEAIAEGVNLARDLVNTPANDLTPEELAERAKELAKEHGLKVEVLDEKE--LEKLGMGALLAVGQGSARPPR 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A      229 FLEIHYKGsPNASEPPLVFVGKGITFDSGGISIKAAANMDLMRADMGGAATICSAIVSAAKLDLPINIVGLAPLCENMPS 308
Cdd:COG0260 239 LIVLEYKG-GGKAKPPVALVGKGVTFDTGGISLKPAAGMEEMKKDMGGAAAVLGAMKAIAELKLPVNVVGLIPAVENMPS 317
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A      309 GKANKPGDVVRARNGKTIQVDNTDAEGRLILADALCYAH-TFNPKVIINAATLTGAMDIALGSGATGVFTNSSWLWNKLF 387
Cdd:COG0260 318 GNAYRPGDVLTSMSGKTVEVLNTDAEGRLVLADALTYAAeRFKPDLIIDLATLTGACVVALGPDTAGLFSNDDALADELL 397
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A      388 EASIETGDRVWRMPLFEHYTRQvIDCQLADVNNIGKyRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGM 467
Cdd:COG0260 398 AAGEAAGEPVWRLPLWDEYREQ-LKSDIADLKNIGG-RFAGAITAALFLRRFVGDTPWAHLDIAGTAWNSGARPYRPKGA 475
                       490
                ....*....|....*..
1LCP_A      468 AGRPTRTLIEFLFRFSQ 484
Cdd:COG0260 476 TGFGVRLLVELLEDRAE 492
PRK00913 PRK00913
multifunctional aminopeptidase A; Provisional
4-479 5.76e-176

multifunctional aminopeptidase A; Provisional


Pssm-ID: 234863 [Multi-domain]  Cd Length: 483  Bit Score: 502.77  E-value: 5.76e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A         4 LVLGIYSKekeedepqFTSAGENFNKLVSGKLREILNISGPPLKAGKTRTFYGL-HEDFPSVVVVGLGKKTAgIDEqenw 82
Cdd:PRK00913  18 LVVGVPER--------LSPAAEQLDKASDGYLSALLKRGDFKGKAGETLLLHAVpGVLAERVLLVGLGKEEE-LDE---- 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A        83 hegkENIRAAVAAGCRQIQDLEIPSV-----EVDPCGDAQAAAEGAVLGLYEYDDLKQK-------RKVVVSAKLHGSED 150
Cdd:PRK00913  85 ----EQLRKAAGKAARALKKTKVKEAvifltELHTYWKARAAAEGALLGLYRFDKYKSKkeprrplEKLVFLVPTRLTEA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A       151 QEAWQRGVLFASGQNLARRLMETPANEMTPTKFAEIVEENLKSASIKTDVFirPKSWIEEQEMGSFLSVAKGSEEPPVFL 230
Cdd:PRK00913 161 EKAIAHGEAIAEGVNLARDLVNEPPNILTPAYLAERAKELAKEYGLEVEVL--DEKEMEKLGMGALLAVGQGSANPPRLI 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A       231 EIHYKGSPnasePPLVFVGKGITFDSGGISIKAAANMDLMRADMGGAATICSAIVSAAKLDLPINIVGLAPLCENMPSGK 310
Cdd:PRK00913 239 VLEYKGGK----KPIALVGKGLTFDSGGISLKPAAGMDEMKYDMGGAAAVLGTMRALAELKLPVNVVGVVAACENMPSGN 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A       311 ANKPGDVVRARNGKTIQVDNTDAEGRLILADALCYAHTFNPKVIINAATLTGAMDIALGSGATGVFTNSSWLWNKLFEAS 390
Cdd:PRK00913 315 AYRPGDVLTSMSGKTIEVLNTDAEGRLVLADALTYAERFKPDAIIDVATLTGACVVALGHHTAGLMSNNDELADELLKAG 394
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A       391 IETGDRVWRMPLFEHYTRQvIDCQLADVNNIGKyRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGMAGR 470
Cdd:PRK00913 395 EESGERAWRLPLGDEYQEQ-LKSPFADMANIGG-RPGGAITAACFLSRFVEKYPWAHLDIAGTAWNSKAWGYNPKGATGR 472

                 ....*....
1LCP_A       471 PTRTLIEFL 479
Cdd:PRK00913 473 GVRLLVQFL 481
Peptidase_M17 pfam00883
Cytosol aminopeptidase family, catalytic domain; The two associated zinc ions and the active ...
166-474 5.31e-175

Cytosol aminopeptidase family, catalytic domain; The two associated zinc ions and the active site are entirely enclosed within the C-terminal catalytic domain in leucine aminopeptidase.


Pssm-ID: 459978  Cd Length: 304  Bit Score: 493.05  E-value: 5.31e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A        166 LARRLMETPANEMTPTKFAEIVEEnLKSASIKTDVFIRPKSWIEEQEMGSFLSVAKGSEEPPVFLEIHYKGSPNAsEPPL 245
Cdd:pfam00883   1 LARDLVNTPANVLTPETFAEAAKE-LAKEYGGVKVEVLDEEELEELGMGAFLAVGKGSEEPPRLVVLEYKGAGPD-DKPI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A        246 VFVGKGITFDSGGISIKAAANMDLMRADMGGAATICSAIVSAAKLDLPINIVGLAPLCENMPSGKANKPGDVVRARNGKT 325
Cdd:pfam00883  79 ALVGKGITFDSGGISLKPAAGMEEMKGDMGGAAAVLGAMRAIAALKLPVNVVAVLPLAENMPSGNAYKPGDVITSMNGKT 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A        326 IQVDNTDAEGRLILADALCYAHTFNPKVIINAATLTGAMDIALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEH 405
Cdd:pfam00883 159 VEVLNTDAEGRLVLADALTYAEKFKPDLIIDVATLTGACVVALGEDYAGLFSNDDELAEELLAAGEATGERVWRLPLWEE 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
1LCP_A        406 YTRQvIDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYlrKGMAGRPTRT 474
Cdd:pfam00883 239 YREQ-LKSDVADLKNVGGGGRAGAITAAAFLKEFVEDTPWAHLDIAGTAWKDDGGGK--KGATGRGVRT 304
PRK05015 PRK05015
aminopeptidase B; Provisional
167-452 5.45e-73

aminopeptidase B; Provisional


Pssm-ID: 235330 [Multi-domain]  Cd Length: 424  Bit Score: 236.69  E-value: 5.45e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A       167 ARRLMETPANEMTPTKFAEIVEENLKSASIKTDVF--IRPKSWIEEQEMGSFlSVAKGSEEPPVFLEIHY--KGSPNAse 242
Cdd:PRK05015 106 VRDTINAPAEELGPEQLAQRAADLICSVAGDAVSYriIKGEDLREQGYMGIH-TVGRGSERPPVLLALDYnpTGDPDA-- 182
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A       243 PPLV-FVGKGITFDSGGISIKAAANMDLMRADMGGAATICSAIVSAAK--LDLPINIVglapLC--ENMPSGKANKPGDV 317
Cdd:PRK05015 183 PVYAcLVGKGITFDSGGYSIKPSAGMDSMKSDMGGAATVTGALALAITrgLNKRVKLF----LCcaENLISGNAFKLGDI 258
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A       318 VRARNGKTIQVDNTDAEGRLILADALCYAHTFNPKVIINAATLTGAMDIALGSGATGVFTNSSWLWNKLFEASIETGDRV 397
Cdd:PRK05015 259 ITYRNGKTVEVMNTDAEGRLVLADGLIDASEQGPPLIIDAATLTGAAKTALGNDYHALFSFDDELAQRLLASAAQENEPF 338
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
1LCP_A       398 WRMPLfEHYTRQVIDCQLADVNNIGKYR-SAGACTAAAFLKEFVTHPK--WAHLDIAG 452
Cdd:PRK05015 339 WRLPL-AEFHRSQLPSNFADLANSGSGAgPAGASTAAGFLSHFVENYQqgWLHIDCSA 395
PTZ00412 PTZ00412
leucyl aminopeptidase; Provisional
105-479 9.81e-66

leucyl aminopeptidase; Provisional


Pssm-ID: 240407 [Multi-domain]  Cd Length: 569  Bit Score: 221.77  E-value: 9.81e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A       105 IPSVEVdpcgdAQAAAEGAVLGLYEYDDLKQKRKVVVSAKLHG-------------------SEDQEAWQRGVLFASGQN 165
Cdd:PTZ00412 142 LPSHDV-----VEKTAIFAVTAAYQYDRLKSGAKGGLTRARRAesrakppaapqppmelvidSSNAQAIAAGNIIGHCVN 216
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A       166 LARRLMETPANEMTPTKFAEIVEENLKSASIKTDVFIRPKSwIEEQEMGSFLSVAKGSEEPPVFLEIHYKGSPNASEPPL 245
Cdd:PTZ00412 217 EARNLGNLREDEGVPQFYAEWIKKELAPLGIKVRKVLRGEQ-LEGAGLNLMYNVGKGSRHEPYLVVFEYIGNPRSSAATA 295
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A       246 VfVGKGITFDSGGISIKAAANMDLMRADMGGAATICSAIVSAAKLDLPINIVGLAPLCENMPSGKANKPGDVVRARNGKT 325
Cdd:PTZ00412 296 L-VGKGVTFDCGGLNIKPYGSMETMHSDMMGAATVMCTLKAIAKLQLPVNVVAAVGLAENAIGPESYHPSSIITSRKGLT 374
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A       326 IQVDNTDAEGRLILADALCYAH-----TFNPKVIINAATLTGAMDIALGSGATGVFTNSSWLWNKLFEASIETGDRVWRM 400
Cdd:PTZ00412 375 VEVLNTDAEGRLVLADTLTYVQkdaklDKKPTTIIDIATLTGAIIVGLGSRRAGLFSNDAHLAQSLMASGRSSGEELWPM 454
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A       401 PLFEHYTRqVIDCQLADVNNIGKYRSAGACTAAAFLKEFVTHP-KWAHLDIAGVMTNKDEvP--YLRKGMAGRPTRTLIE 477
Cdd:PTZ00412 455 PIGDEHKD-AMKGGIADLINVASGREAGSCTAAAFLSNFVEPEvKWAHLDIAGVGMGGDK-PkgFQPAGAPGFGVQLLVD 532

                 ..
1LCP_A       478 FL 479
Cdd:PTZ00412 533 YF 534
Peptidase_M17_N pfam02789
Cytosol aminopeptidase family, N-terminal domain;
5-134 5.51e-16

Cytosol aminopeptidase family, N-terminal domain;


Pssm-ID: 426984 [Multi-domain]  Cd Length: 127  Bit Score: 74.30  E-value: 5.51e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LCP_A          5 VLGIYskekeeDEPQFTSAGENFNKLVSGKLREILNISGPPLKAGKTRTFYGL-HEDFPSVVVVGLGKKTAgideqenwh 83
Cdd:pfam02789   1 VVGVF------EGGKLSPAAEKLDEALQGLLSELLKEGDFKGKAGETLLLRSLpGIKAKRVLLVGLGKEEE--------- 65
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
1LCP_A         84 EGKENIRAAVAAGCRQIQDL----------EIPSVEVDPCGDAQAAAEGAVLGLYEYDDLK 134
Cdd:pfam02789  66 LTAEALRKAAGAAARALKGAkvttvavllpELNVKNRDAYEKARAAAEGLLLGLYRFDRYK 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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