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Conserved domains on  [gi|15825784|pdb|1I8N|A]
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Chain A, ANTI-PLATELET PROTEIN

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAN_APPLE cd00129
PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth ...
 44-122 1.15e-31

PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech anti-platelet proteins. Common structural features include two disulfide bonds that link the alpha-helix to the central region of the protein. PAN domains have significant functional versatility, fulfilling diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


:

Pssm-ID: 238074  Cd Length: 80  Bit Score: 107.40  E-value: 1.15e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1I8N_A       44 EDCWSKRPGWKLPD--NLLTKTEFTSVDECRKMCEESAVEPSCYILQINTETNECYRNNEGDVTWSSLQYDQpNVVQWHL 121
Cdd:cd00129   1 VDEFCKSAGTTLIKiaLKIKTTKANTADECANRCEKNGLPFSCKAFVFAKARKQCLWFPFNSMSGVRKEFSH-GFDLYEN 79


                .
1I8N_A      122 H 122
Cdd:cd00129  80 K 80
 
Name Accession Description Interval E-value
PAN_APPLE cd00129
PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth ...
 44-122 1.15e-31

PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech anti-platelet proteins. Common structural features include two disulfide bonds that link the alpha-helix to the central region of the protein. PAN domains have significant functional versatility, fulfilling diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238074  Cd Length: 80  Bit Score: 107.40  E-value: 1.15e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1I8N_A       44 EDCWSKRPGWKLPD--NLLTKTEFTSVDECRKMCEESAVEPSCYILQINTETNECYRNNEGDVTWSSLQYDQpNVVQWHL 121
Cdd:cd00129   1 VDEFCKSAGTTLIKiaLKIKTTKANTADECANRCEKNGLPFSCKAFVFAKARKQCLWFPFNSMSGVRKEFSH-GFDLYEN 79


                .
1I8N_A      122 H 122
Cdd:cd00129  80 K 80
 
Name Accession Description Interval E-value
PAN_APPLE cd00129
PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth ...
 44-122 1.15e-31

PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech anti-platelet proteins. Common structural features include two disulfide bonds that link the alpha-helix to the central region of the protein. PAN domains have significant functional versatility, fulfilling diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238074  Cd Length: 80  Bit Score: 107.40  E-value: 1.15e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1I8N_A       44 EDCWSKRPGWKLPD--NLLTKTEFTSVDECRKMCEESAVEPSCYILQINTETNECYRNNEGDVTWSSLQYDQpNVVQWHL 121
Cdd:cd00129   1 VDEFCKSAGTTLIKiaLKIKTTKANTADECANRCEKNGLPFSCKAFVFAKARKQCLWFPFNSMSGVRKEFSH-GFDLYEN 79


                .
1I8N_A      122 H 122
Cdd:cd00129  80 K 80
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 44-122 2.74e-06

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 42.46  E-value: 2.74e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1I8N_A       44 EDCWSKR--PGWKLPDNLLTKTEFTSVDECRKMCEESaVEPSCYILQINTETNECYRNNEGDVTWSSLQYDQPNVVQWHL 121
Cdd:cd01099   1 LNDFKFVlvLNKILVSEVKTEITVASLEECLRKCLEE-TEFTCRSFNYNYKSKECILSDEDRMSSGVKLLYDSNVDYYEN 79


                .
1I8N_A      122 H 122
Cdd:cd01099  80 K 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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