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Conserved domains on  [gi|10120955|pdb|1FG9|C]
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Chain C, INTERFERON-GAMMA RECEPTOR ALPHA CHAIN

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Interfer-bind super family cl46366
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 144-223 1.26e-22

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


The actual alignment was detected with superfamily member pfam07140:

Pssm-ID: 480706  Cd Length: 133  Bit Score: 89.46  E-value: 1.26e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FG9_C        144 YDPETTC-YIRVYNVYVRMNGSEIqYKILTQKEDDCDEIQCQLAIPVSSlnsQYCVSAEGVLHVWGVTTEKSKEVCITIF 222
Cdd:pfam07140   1 YGNGTTCdYTFGYTVYFLFNDSKE-ILEYSVDDRYCDEVQCRFNIESQE---NVCVSVVGVYGNWYVRTEASKDVCVPEL 76


                  .
1FG9_C        223 N 223
Cdd:pfam07140  77 V 77
Tissue_fac super family cl47630
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 8-96 1.04e-19

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


The actual alignment was detected with superfamily member pfam01108:

Pssm-ID: 460067  Cd Length: 107  Bit Score: 81.28  E-value: 1.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FG9_C          8 GPSSVPTPTNVTIESYNMNPIVYWEY-QIMPQVPVFTVEVKNYGVKNSEWIDACINISHHYCNISDHVGDPSNSLWVRVK 86
Cdd:pfam01108  18 GGPSLPAPQNVTFQSTNFKNILTWEPgPNSPPDVVYTVQYKIYGSGDWKNVPNCTNITRTECDLTDETSDLTETYYARVR 97

                          90
                  ....*....|
1FG9_C         87 ARVGQKESAY 96
Cdd:pfam01108  98 AVSGGGTSSW 107
 
Name Accession Description Interval E-value
IFNGR1 pfam07140
Interferon gamma receptor (IFNGR1); This family consists of several eukaryotic and viral ...
 144-223 1.26e-22

Interferon gamma receptor (IFNGR1); This family consists of several eukaryotic and viral interferon gamma receptor proteins. Molecular interactions among cytokines and cytokine receptors in eukaryotes form the basis of many cell-signaling pathways relevant to immune function. Human interferon-gamma (IFN-gamma) signals through a multimeric receptor complex consisting of two different but structurally related transmembrane chains: the high-affinity receptor-binding subunit (IFN-gammaRalpha) and a species specific accessory factor (AF-1 or IFN-gammaRbeta). The vaccinia viral interferon gamma receptor has been shown to be secreted from infected cells during early infection. The structure has been halved such that the N-terminus of this family is now represented by Tissue_fac pfam01108.


Pssm-ID: 284538  Cd Length: 133  Bit Score: 89.46  E-value: 1.26e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FG9_C        144 YDPETTC-YIRVYNVYVRMNGSEIqYKILTQKEDDCDEIQCQLAIPVSSlnsQYCVSAEGVLHVWGVTTEKSKEVCITIF 222
Cdd:pfam07140   1 YGNGTTCdYTFGYTVYFLFNDSKE-ILEYSVDDRYCDEVQCRFNIESQE---NVCVSVVGVYGNWYVRTEASKDVCVPEL 76


                  .
1FG9_C        223 N 223
Cdd:pfam07140  77 V 77
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 8-96 1.04e-19

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 81.28  E-value: 1.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FG9_C          8 GPSSVPTPTNVTIESYNMNPIVYWEY-QIMPQVPVFTVEVKNYGVKNSEWIDACINISHHYCNISDHVGDPSNSLWVRVK 86
Cdd:pfam01108  18 GGPSLPAPQNVTFQSTNFKNILTWEPgPNSPPDVVYTVQYKIYGSGDWKNVPNCTNITRTECDLTDETSDLTETYYARVR 97

                          90
                  ....*....|
1FG9_C         87 ARVGQKESAY 96
Cdd:pfam01108  98 AVSGGGTSSW 107
 
Name Accession Description Interval E-value
IFNGR1 pfam07140
Interferon gamma receptor (IFNGR1); This family consists of several eukaryotic and viral ...
 144-223 1.26e-22

Interferon gamma receptor (IFNGR1); This family consists of several eukaryotic and viral interferon gamma receptor proteins. Molecular interactions among cytokines and cytokine receptors in eukaryotes form the basis of many cell-signaling pathways relevant to immune function. Human interferon-gamma (IFN-gamma) signals through a multimeric receptor complex consisting of two different but structurally related transmembrane chains: the high-affinity receptor-binding subunit (IFN-gammaRalpha) and a species specific accessory factor (AF-1 or IFN-gammaRbeta). The vaccinia viral interferon gamma receptor has been shown to be secreted from infected cells during early infection. The structure has been halved such that the N-terminus of this family is now represented by Tissue_fac pfam01108.


Pssm-ID: 284538  Cd Length: 133  Bit Score: 89.46  E-value: 1.26e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FG9_C        144 YDPETTC-YIRVYNVYVRMNGSEIqYKILTQKEDDCDEIQCQLAIPVSSlnsQYCVSAEGVLHVWGVTTEKSKEVCITIF 222
Cdd:pfam07140   1 YGNGTTCdYTFGYTVYFLFNDSKE-ILEYSVDDRYCDEVQCRFNIESQE---NVCVSVVGVYGNWYVRTEASKDVCVPEL 76


                  .
1FG9_C        223 N 223
Cdd:pfam07140  77 V 77
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 8-96 1.04e-19

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 81.28  E-value: 1.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FG9_C          8 GPSSVPTPTNVTIESYNMNPIVYWEY-QIMPQVPVFTVEVKNYGVKNSEWIDACINISHHYCNISDHVGDPSNSLWVRVK 86
Cdd:pfam01108  18 GGPSLPAPQNVTFQSTNFKNILTWEPgPNSPPDVVYTVQYKIYGSGDWKNVPNCTNITRTECDLTDETSDLTETYYARVR 97

                          90
                  ....*....|
1FG9_C         87 ARVGQKESAY 96
Cdd:pfam01108  98 AVSGGGTSSW 107
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 109-221 3.67e-03

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 36.17  E-value: 3.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FG9_C        109 KIGPPKLDIRKEEKQIMIDIFHPSVFVNGDEQEVDYDPETTcyirvYNVYVRMNGSEIQYKILTQKEDDcdeiqcqLAIP 188
Cdd:pfam09294   2 IIGPPEVELEVEGGSLNVTVKDPETREGKNLSLRDLYGSLQ-----YRVSYWKNSSNGEKKNTTSTNSF-------VVLS 69

                          90       100       110
                  ....*....|....*....|....*....|...
1FG9_C        189 VSSLNSQYCVSAEGVLHVWGVTTEKSKEVCITI 221
Cdd:pfam09294  70 DLEPGTTYCVSVQAFSPLDNKSSQRSPPQCIRT 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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