1XYG,2EP5,2YV3,1YS4,1VKN,2QZ9,2GYY,2G17,1T4B,2OZP,2HJS


Conserved Protein Domain Family
Semialdhyde_dh

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smart00859: Semialdhyde_dh 
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Semialdehyde dehydrogenase, NAD binding domain
The semialdehyde dehydrogenase family is found in N-acetyl-glutamine semialdehyde dehydrogenase (AgrC), which is involved in arginine biosynthesis, and aspartate-semialdehyde dehydrogenase, an enzyme involved in the biosynthesis of various amino acids from aspartate. This family is also found in yeast and fungal Arg5,6 protein, which is cleaved into the enzymes N-acety-gamma-glutamyl-phosphate reductase and acetylglutamate kinase. These are also involved in arginine biosynthesis. All proteins in this entry contain a NAD binding region of semialdehyde dehydrogenase.
Statistics
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PSSM-Id: 214863
Aligned: 487 rows
Threshold Bit Score: 35.9872
Created: 14-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1XYG_A        18 RIGLLGASGYTGAEIVRLLANHPhFQVTl-mTAD--RKAGQSMESVFPHLRaQk-lPTLVSVKDAdfstvDAVFCCLPHG 93  thale cress
YP_001342636   6 RAVIIGPGNIGTDLLIKMKR-SDwIEPVwmvGIDpdSDGLKRARDMGIKTT-HqgiDDFIDYLIAdd--iRIAFDATSAY 81  Marinomonas sp....
YP_700510      5 KVAVIGSGNIGTDLVIKLEQVAKnVEIAvlvGIDpaSDGLARARRLGISTV-DtgvQGLIEHPEFdd--iEIIFDSTSAK 81  Rhodococcus sp....
YP_001262141   6 KAAIIGSGNIGTDLMIKMIKYPQnMELAavvGIDpaSEGLAMARERGIATT-HegiEGLKKLPDYae--iGVVFDATSAY 82  Sphingomonas wi...
YP_001160335   4 GVAVLGSGNIGTDLMIKVLRLSDsLRMVamaGIDpdSDGLARARRLGVTTT-AegvAGLVALPEFad--vALVFDATSAG 80  Salinispora tro...
YP_367333      9 AVAIIGSGNIGTDLMIKVLRHAKhLDVAamvGIDpaSDGLARAARLGVPTT-AggiDGLVAMPGFad--vRIAFDATSAG 85  Burkholderia sp...
YP_001268203   9 AVAIIGSGNIGTDLMVKILRHGKhLRMGafvGIDpeSDGLKRAERMGVPTV-StgiEGLLSHPDFgs--iGFVFDATSAG 85  Pseudomonas put...
YP_003498077   5 KVAIIGSGNIGTDLMIKILRHDQhLEMAvmvGIDpqSDGLARARRMGVATT-HegvIGLMNMPEFad--iDIVFDATSAG 81  Escherichia col...
YP_955174      3 KVAIIGSGNIGTDLMIKVLRVSDlLEVAamvGIDpdSDGLARARRLKVQTT-HegvEGLLALDEFde--iDIVFDATSAG 79  Mycobacterium v...
YP_922850      5 KVAIIGSGNIGTDLMIKVLRTSKhLEMGamvGIDpaSDGLARAGRFGVPTT-AegvEGLVALPGFdd--iEIVFDATSAG 81  Nocardioides sp...
1XYG_A        94 TTQEIIKelp---talKIVDLSADFRLRniaeyeewygqphkavelqkevvYGLTEILREDIKKA 155 thale cress
YP_001342636  82 VHEENSRklna--lgvVMIDLTPAAIGP-----------------------YCIPPVNLEEHANN 121 Marinomonas sp. MWYL1
YP_700510     82 AHLTNAEalrp--ygkHLIDLTPAAIGP-----------------------YVVPAVNLDQHLGA 121 Rhodococcus sp. RHA1
YP_001262141  83 AHKVHDEalra--dgkLVVDLTPAAIGP-----------------------FTIPPVNMDEHLDA 122 Sphingomonas wittichii RW1
YP_001160335  81 AHRHHDAvlra--hgrTVVDLTPAAVGP-----------------------YVVPPVNLDEHLRE 120 Salinispora tropica CNB-440
YP_367333     86 AHARHAEvlgr--hgvQVIDLTPAAIGP-----------------------FVVPVVNLFEHLDA 125 Burkholderia sp. 383
YP_001268203  86 AHARHEQllrp--hgvRVIDLTPAAIGP-----------------------FVVPAVNIEQHLDA 125 Pseudomonas putida F1
YP_003498077  82 AHVKNDAalreakpdiRLIDLTPAAIGP-----------------------YCVPVVNLEENVDQ 123 Escherichia coli O55:H7 str. C...
YP_955174     80 AHIKNAEtlrk--fgkYLVDLTPAAIGP-----------------------FVVPAVNLTDQLNR 119 Mycobacterium vanbaalenii PYR-1
YP_922850     82 AHVVNAArllp--lgkRLIDLTPAALGP-----------------------FTIPAVNLEDHLEA 121 Nocardioides sp. JS614
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