2EP7,3CPS,3L0D,2B4R,3HJA,1GD1,3GNQ,1HDG,1S7C,1U8F,1VC2,3LC1,2X5J,2D2I,3E5R,2X0N,3K2B,2VYN,2CZC,1B7G


Conserved Protein Domain Family
Gp_dh_N

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smart00846: Gp_dh_N 
Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
GAPDH is a tetrameric NAD-binding enzyme involved in glycolysis and glyconeogenesis. N-terminal domain is a Rossmann NAD(P) binding fold.
Statistics
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PSSM-Id: 214851
Aligned: 449 rows
Threshold Bit Score: 47.5464
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2EP7_A         3 IKVGINGFGRIGRSFFRASWGR--EEIEIVAINDl-TDAKHLAHLLKy-DS-----VHGIF-KGSVE-------AK---D 62  Aquifex aeolicus
YP_001040113   1 MRIGIYGFGSIGRLVAREAVKRgwEIVGAIDIDEk-IIGKDIGEILGf-EE-----KYGVV--VSRD-------VE---E 61  Staphylothermus...
NP_147019      4 VKVGVNGFGTIGRRVALAITLQ--KDMKLVGVVK--RTPDYAALy----AA-----SRGIpiYTPTAk-----eAEefeK 65  Aeropyrum perni...
NP_279245      2 IRVGINGYGTIGKRVADAVAAQ--PDMTVAGVAK--TSPNFEATQAR--KR-----GFDLY--TAVE-------DR---A 58  Halobacterium s...
YP_136798      2 LHVGINGFGTIGKRVADAVRVQ--PDMTVAGVAK--RSPNFEATIAD--DR-----GYDLY-AA--Dgr---epFD---E 61  Haloarcula mari...
YP_325669      3 IQVAVNGYGTIGKRVADAVTLQ--PDMELVGVAK--TSPNHEAELAV--EN-----DYPLY-AAIEDri---ddFE---A 64  Natronomonas ph...
CCC39373       2 IRVGVNGYGTIGKRVADAVALQ--PDMEVVGVAK--TKPNFEAHTAD--QR-----GYEMY-AAIPDra---plFG---D 63  Haloquadratum w...
YP_657783      2 IHVGVNGYGTIGKRVADAVDMM--PDMELTGVSKasPNHTADAAADRgyDIyvpeeRHDRWaDTEMTvtgdvheLI---- 75  Haloquadratum w...
YP_921163      5 IRVLVNGIGTIGKRVAHAVSLQ--PDMVLVGVSS----PRPSLGVLS---------SLSRG--GVLE------------G 55  Thermofilum pen...
2CZC_A         3 VKVGVNGYGTIGKRVAYAVTKQ--DDMELIGITK--TKPDFEAYRAK--EL-----GIPVY-AASEEfi---prFE---K 64  Pyrococcus hori...
2EP7_A        63 DSIVVDGKEIKVFAQKdpsqip-----wgdlgvDVVIEA-T-GVFRDRENAsKHLQGGAKKVIITA-PAKNPDi----TV 130 Aquifex aeolicus
YP_001040113  62 ---LIDa--------------------------DVVVHA-T-SS---------YLD-KVYDQIL--------------SL 86  Staphylothermus...
NP_147019     66 RGIKVGGTLRELLAr-----------------vDVVVDAtP-EG-QGAKNKpLYREAGVKQVYQGG-EKPEVAe---aSF 122 Aeropyrum perni...
NP_279245     59 DQFPAAGI------ETagpvdd------liadsDVVVDAtP-SG-VGAENRsRYAAHDTPAIYQGG-EDASVAd---vSF 120 Halobacterium s...
YP_136798     62 ADLGTAGTVHDLIETS-----------------DVVVDTtP-SGVGAANAS-LYAEHDTPAIFQGG-EDADVAd---vSF 118 Haloarcula mari...
YP_325669     65 AGIDLAGTVDELVEAA-----------------DIVVDAcP-SGIGADNKS-LYEAHDTPALYQGG-ESADLVd---vSF 121 Natronomonas ph...
CCC39373      64 AGVELAGAVDELVAAA-----------------DIMIDCtP-SGIGAENKS-LYESYDTPAIFQGG-EDATIAe---vSF 120 Haloquadratum w...
YP_657783     76 ----------EIS--------------------DIVADTtP-PG-MGAEYRpIYEEHDTPALFQGG-ESADAVe---aSF 119 Haloquadratum w...
YP_921163     56 VPFYVRGASPSLFEERgvrvggvledllgsgrvDVVVDAaP-GGEGLRNRDeLYSRYGVRAVFQGGePAAVAEltfspFF 134 Thermofilum pen...
2CZC_A        65 EGFEVAGTLNDLLEKv-----------------DIIVDA-TpGGIGAKNKp-LYEKAGVKAIFQGG-EKADVAe---vSF 121 Pyrococcus hori...
2EP7_A       131 VL-GVNEEKYNPKEhnIISNASC 152 Aquifex aeolicus
YP_001040113  87 VRlGIDT---------VST---C 97  Staphylothermus marinus F1
NP_147019    123 ST-LCNYEESKGRG--SLRVVSC 142 Aeropyrum pernix K1
NP_279245    121 NA-RANFEAAADAD--HVRVVSC 140 Halobacterium sp. NRC-1
YP_136798    119 NA-RANYEKAVGAD--TARVVSC 138 Haloarcula marismortui ATCC 43049
YP_325669    122 NA-RSNFEAAADAD--HVRVVSC 141 Natronomonas pharaonis DSM 2160
CCC39373     121 NA-RANYAAACGTD--SVRVVSC 140 Haloquadratum walsbyi C23
YP_657783    120 TA-RANYSEATNKD--YVRIVSC 139 Haloquadratum walsbyi DSM 16790
YP_921163    135 NY-G---DAFGRR---YVRVPSC 150 Thermofilum pendens Hrk 5
2CZC_A       122 VA-QANYEAALGKn--YVRVVSC 141 Pyrococcus horikoshii OT3
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