3JD5,8D8K


Conserved Protein Domain Family
DAP3

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pfam10236: DAP3 (491016 is an unknown moldel)
Mitochondrial ribosomal death-associated protein 3
This is a family of conserved proteins which were originally described as death-associated-protein-3 (DAP-3). The proteins carry a P-loop DNA-binding motif, and induce apoptosis. DAP3 has been shown to be a pro-apoptotic factor in the mitochondrial matrix and to be crucial for mitochondrial biogenesis and so has also been designated as MRP-S29 (mitochondrial ribosomal protein subunit 29).
Statistics
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PSSM-Id: 491016
Aligned: 23 rows
Threshold Bit Score: 288.053
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3JD5_g        98 LMVRKPALELLHYLKNT-NFAHPAVRYVLYGEKGTGKTLSLCHIIHFCAKQ-DWLILHIPDAHLWVKNCRDLLQSTy-NK 174 domestic cattle
O59677       170 LLHRKITTELVNVLQRSkDQGTKDGRFLLDGAPGSGRSIALIQAELFALSQpNFIVLPVHNCEGWVNSTSSYGYDE--QL 247 Schizosaccharom...
1_pfamImport   1 -MVRSPALEVISYLKKT-DNTRPAVRYLFYGLKGSGKTMSLCHVVHFCYTQ-GWLVLHIPDAHIWVKNCKELLPSSy-NR 76 
2_pfamImport   1 LMVRRPAVEIMEYLQRT-DFARPVNRFVLHGEDGVGKSLVLAHLLHYGFQQ-QYVLIHVPWVPNWMKRAKEIANSAs-HE 77 
Q9W253        93 LMVRNPALELLQYIKDG-DLTKPVVRYVLYGENGTGKTLTMAHVLHYGALN-DFLLVHVPWAPNWMKRPKEASNAAg-QE 169 fruit fly
Q5KNX8       123 SVVREATLDLVKRVEAAkTGSSKLARYILTGEQGSGKSVLLVQSVAYAIES-GWIVLYSPRASKWVNSTSQYIYDP--ET 199 Cryptococcus ne...
XP_011392248 143 SLVRKQTLELLDKLDAA-SKAMKGESIVLDGRGGSGKSMLLAQSIAYALDD-GWVVVSVPRAINLINSSTLYTYNA--QH 218
8D8K_W       124 CLVREDA---TNSFLKK-LVSHPVKKFIITGEPGVGKTVLLSQAHAYAVDS-KQIIINISYPELFLNGRNDFSYDD--DL 196 brewer's yeast
XP_001642299 116 SLVREGT---TKKFLDL-LKKSANKKFIVTGEPGVGKTVLLSQVHAFATEA-KSITVNISYPELFLNGRNDFFYDE--NS 188
Q755C9       113 CYTREATGQLLERLSGT-----EHQRVILTGQPGVGKSTLLAQAQVAAFEK-GSVIINISHPELFLNGRNDFRHDTtgEQ 186 Eremothecium go...
3JD5_g       175 QRFDQPLEASIWLKNFKTANE-RFLSQIK--VQDKYVWNk-----------RESTEKGsPLAEVVEQGIMRVRNATDA-- 238 domestic cattle
O59677       248 KLWVQPDLIKGFLTSVMKTNS-DKLKKLK--TFESHELLq-----------NECIPAGtDLLSFLHKLIASSNAPK-S-- 310 Schizosaccharom...
1_pfamImport  77 ARFDQPLQANEWLRNFKTTNE-KFLSTIK--TKHRYVWTk-----------RESTNEGsTLGELVDQGINRMKSSSDV-- 140
2_pfamImport  78 GSIDLPLDGAAWLVHFKSQNG-PLIKSLGltVSREYVWTk-----------RETTPAGaPLMELVEHGINRAKFSCDT-- 143
Q9W253       170 GMIDLPFDAAAWLVHFKTQNG-PLLQRLQlkTSKEYVWSk-----------RESTPAGsSLIELVEHGIARIKYASET-- 235 fruit fly
Q5KNX8       200 KTYAQWESAQNILSVLLETNR-DKLSAIE--LSEKVELTk-----------GKSVEAGeTVAALAQLGAKDDRSAVKA-- 263 Cryptococcus ne...
XP_011392248 219 QAYLQPEATTQLLEAILKVNG-AAAKQIK--SAEAVEVD------------GSKIDAGtPLETLLKRGMDDSSSAAAKqt 283
8D8K_W       197 KLFIQPMYLKKLIRKILKANDpALLKSIE--LSKDYKFSnanpknasvkpfVTLNKTKnTVLDLLSVMTHPHNRGK-L-- 271 brewer's yeast
XP_001642299 189 KLYVQPMYLKSFIRKILKGNDkSVLKSIT--LANDYKFPnndskd-vnrkhLTLFGGKnTLYDLLSVKTVSRSRGE-L-- 262
Q755C9       187 EQYTQPMYLKKLLTKILKSNKkSVLSSVA--LTQEYKFPvadtresaskrvTRLVPGKtPLYGLLSMKTTPAARGM-L-- 261 Eremothecium go...
3JD5_g       239 -VGIVLKELKRQSSl--gVFRLLVAVDGVNALWGR--TTLKREDKSPITPEELALIYNLRKM---VKNDWQGGAIvltVS 310 domestic cattle
O59677       311 -LEIFLQELNNNTKsn-sNMKVLLVIDNISILSVV--TKYKDKKNNFLPPKDFYFINLLFKYi-sGSLTFNRGTV---LA 382 Schizosaccharom...
1_pfamImport 141 -VAAVMKELRLQSGqpesNFRLAVAVDGVNALWGR--STIKKEDKSFVDPEELTLVYNLRKL---MRNDWAGGAIittLS 214
2_pfamImport 144 -IAALVEELKQHASa--gRARAMVVIDGYNAFFQPh-TRLLTEAKARITPDQITLTKPFLSI---TRNDWTNGVCvvtVD 216
Q9W253       236 -TAALIAELKQLSTa--gQCKVMVAIDGFNAFFHPv-TRIFSDNKQLVTPDRVTLTQPFLDI---TNYDWTNGVCilsVD 308 fruit fly
Q5KNX8       264 -LEAVVGALEKQTQ-----FPVLWAIDEAQSLFNT--SKYRAADYTPIEPYHLSTPRLALDFi-aARRSFSRGAVvtsLS 334 Cryptococcus ne...
XP_011392248 284 lLEAVFKTLSSQSE-----RPVLVAVDDAQALFRT--SLYKDPDFINLESFELGIPRALLSLlisPSSAISRGVFiaaLS 356
8D8K_W       272 -MKAIIDELSVQSK-----VPIMFTVDNFSKVLTTaySAYRNTENKQIYSLDLQMGKLMMDIi-sGETKFANGESstiLA 344 brewer's yeast
XP_001642299 263 -FQSIMQELKSQSK-----VPVYFTIDNFSRILVTsdCAYKNVNNKNIRSLDLQIVKTIMDFv-sGDSKFKNKNSaivMA 335
Q755C9       262 -FQAVIDELVAQSA-----VPVYLTVDNFSRILSEplSAYKDTSCRSIHVLKLQLGRIIMNFv-sGATKLNHKDSrvvLA 334 Eremothecium go...
3JD5_g       311 QTGSLFKPRKAYLPQELLGKEGFdt---------------lDPFI-------------------PILVS-NYNPKEFEGC 355 domestic cattle
O59677       383 ATSSQPRVSTPSLDIALGVAHR-------------------NPYKssdetil-----dslqsvhILNME-PYTLDESRRM 437 Schizosaccharom...
1_pfamImport 215 QTGSLYTSRAEYLPQELLGEMGFdn---------------mDPFV-------------------PVSVP-NYSEKEFESC 259
2_pfamImport 217 QMVKEFKDTAAGRQSSAVAGPAQvqepslallesrecfehlDPFV-------------------PVSVV-GYDDAEYYSC 276
Q9W253       309 KIAMTEGHMDSYMPRYLLGKEGFeh---------------lDPFV-------------------PIHVE-NYTDKEFHSY 353 fruit fly
Q5KNX8       335 LSDPSNLPS-PAIRSALSISSSSp----------------lTPYTainpyhl-----ahaenltPINVPyGMNSEEAAGL 392 Cryptococcus ne...
XP_011392248 357 TTHTEFPSP-PELQNALSEKSSSdgtskl-------ltqaiNAYTklnahhleh-arkvvkhadVVDTSkPLTKEEAAAI 427
8D8K_W       345 ISGVDRTNK--TLPVALGKIPV-------------------DPYVtryhyepkfvellqkgnvtEFEVP-KLNKQEVNEL 402 brewer's yeast
XP_001642299 336 TSGDDRTNR--TLPIALGKAQH-------------------DEYIprkqydpefaeilkkgkveEFQVP-KLTKEEVKEL 393
Q755C9       335 TSGVDRETK--TLPTGLGQTPH-------------------DPYAakynydavlaemmlkggvkEFRVE-PLSKPEVAEL 392 Eremothecium go...
3JD5_g       356 IQYYLENNWLQHEk----AHTEEGKKELLFLsNrnpglleRL 393 domestic cattle
O59677       438 MEYLVSSNVCLEK-----VDNYLQNHVLS---GgnprkffDA 471 Schizosaccharomyces pombe 972h-
1_pfamImport 260 YLYYTDRHWLQHPq----SLTEDGKKELIFLsNrnpsvfeRL 297
2_pfamImport 277 IQYYLERKWIQ-------TNEPGFEEELKLLsCqnpyqlmQL 311
Q9W253       354 ISYYLDRHWIN-------KTPQGFEEQLKFMsNknpyslmQL 388 fruit fly
Q5KNX8       393 FELFTKKGWAPN------GSDELFMESFIAS-QgnpremgKG 427 Cryptococcus neoformans
XP_011392248 428 FAQLRDERRYWSA-----VNDELFLEKLVES-NgnvrlfsKS 463
8D8K_W       403 IDYYKQSNVLLDKditgkKWENLIDEKYFLSgNgnprellKS 444 brewer's yeast
XP_001642299 394 MSFYLESDIVLKKdkdskSLDQLVDEKYFLSgNgnpreliKS 435
Q755C9       393 VDFYAKAGILSEKdqenrREGRLVDEKYLLSgNgnlrellKS 434 Eremothecium gossypii
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