2DKH


Conserved Protein Domain Family
Phe_hydrox_dim
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pfam07976: Phe_hydrox_dim 
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Phenol hydroxylase, C-terminal dimerization domain
Phenol hydroxylase acts a homodimer, to hydroxylates phenol to catechol or similar product. The enzyme is comprised of three domains. The first two domains from the active site. The third domain, this domain, is involved in forming the dimerization interface. The domain adopts a thioredoxin-like fold.
Links
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Statistics
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PSSM-Id: 429765
Aligned: 243 rows
Threshold Bit Score: 97.2193
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2DKH_A       441 FTAGVGTHYAPSLLtgqakhqALASG--------------FTVGMRFHSAPVVRVCDAKPVQLGHCGKADGRWRLYAFAa 506
EEQ90998     466 FTSGYGVVYQPNIF-------NWGPDhpaksplfnppgvkLVPGRVFPSCTVTRLSDSNKVALEQAVPANGSFRIHIFA- 537
XP_002794301 446 LTSGYGVAYQPNIF-------NWGPDhpakspllnsvgvkLVSGRPFPPCTVTRLSDAYKVALEQEVPINGSFRIHIFA- 517
XP_002487142 409 FTSGYGVAYDPNVI-------NWSPShpaqshlfgidgvkLVPGRAFTPTTVTRLSDANMIHLEQEVPANGSFRVFVFA- 480
GAD91775     410 FTSGYGVAYNANIF-------NWSPShpaksplfnvpgvkLRVGRAFTPSKVTRLSDANFVNLEQEVPANGAFRIFVFA- 481
EPS32694     408 FTSGYGVAYKPNVF-------NWDAShpaksslfdisgvrLTPGRAFTPSMVTRLADANFVELEQEVPVNGSFRIYVFA- 479
C8VBV0       413 FTSGYGVAYLPNIF-------NWDPShpaksplfdvpginLVTGKAFTPSTVTRLADSNFVHLEQEIPANGAFRIFIFA- 484 Aspergillus nid...
EHA21143     412 FTSGYGVAYKPNVF-------TWDAThpaqsplfdvpgvrLTPGRAFTPTTVTRLADSNHVHLEQEIPANGAFRIFIFA- 483
Q4WZW6       411 FTSGYGVAYKPNVF-------NWSPShpaqsplfdipgikLTPGRAFTPTTVTRLADANFVHLEQEIPANGAFRIFIFA- 482 Aspergillus fum...
XP_003172284 399 FTSGYGIVYPPNVF-------NWHPNhraksplfisdgtiLTPGRCFPPATVTRLADSNPVHLEHEIPMNGSFRILIFA- 470

2DKH_A       507 qNDlaQPE----SGLLALCRFLEGDaaSPLRRFTPAgQ----------DIDSIFDLRAVFPQAYTEVALETLPALLLppk 572
EEQ90998     538 -GN--PDKt--rQAVNDFASNLEKKr-SFLSSYQRRdIdtvshferhnPHSHLFTFCLTYSNTEGSGAIDHLPKLLK--- 608
XP_002794301 518 -GN----PaktrEAVNDFASHLVKKl-SFYSSYQQRdIdtvsyferhnPHSRFFTLTVIFSGQKCAKRIDQLPKVLR--- 588
XP_002487142 481 -GT----PqkskKALEDFASYIEKEk-SFLSVYRRPdIanvsyferhnPHSKLFTLNFIFASEKNGVDMQSLPQIVK--- 551
GAD91775     482 -GV----PaktkQALTDFAASLEKEr-SFLSVYRRPdIssvshferhnPHSKLFTISVVYASDKNGINLPELPNLLK--- 552
EPS32694     480 -GN----QaktsKAIADFAANLEKEr-SFLSAYRRPdIasvsfferhnPHSKLFTISVIYAANKNEVDVDSIPQILR--- 550
C8VBV0       485 -GR----QsrskKAIADFAANLEKEr-SFLSAYRRSdIgeisfferhnPHSKLFTLCLIYAEKKNDIDMDSIPQILR--- 555 Aspergillus nid...
EHA21143     484 -GK----QdktsKAITDLAANLEKEr-SFLSVYRRAdIadvsffenhlPHSKLFSICLVYAGEKNQIDVDSIPKILR--- 554
Q4WZW6       483 -GK----QantkKAITDFGANLEKEr-SFLSSYRRIdeisf--ferhlPHSKLFSICLIYAAQKNEVDVEAIPQILR--- 551 Aspergillus fum...
XP_003172284 471 -GS----LdksrTALADFCRYIEEPs-SFYALFATPeLcpdpyfekhnPHSRFFTIAAVFMEEKDNVDISTLPRLLK--- 541

2DKH_A       573 gqlgmiDY-EKVFSPDl--kN--AG-QD-IFELRGID-RQQG 606
EEQ90998     609 ------AYrHHIYVDNvpdiKapNArAA-AHTKLGFD-TERG 642
XP_002794301 589 ------DYrHHIYVDDipdiKm-pNaKaaAHSKVGFDaEQ-G 622
XP_002487142 552 ------DYhHHIYADDipdvRv-pHaKysAHEKLGFDpEQ-G 585
GAD91775     553 ------AYhHHIYADDlpdvRv-pQaKfaAHEKLGFDpTK-G 586
EPS32694     551 ------DYhHHLYADDipdiRv-pQaKfaAHEKLGFDvEK-G 584
C8VBV0       556 ------DYrYHIYSDDipdvRv-pNaTyaAHEKLGFDpEK-G 589 Aspergillus nidulans FGSC A4
EHA21143     555 ------DYhHHLYADNipdvRv-pQaTyaAHEKLGFDvEK-G 588
Q4WZW6       552 ------DYhHHIYADDipdvRv-pLaKfaAHEKLGFDpEK-G 585 Aspergillus fumigatus
XP_003172284 542 ------AYhHHIYADDlvhkSa-aQpIgsIHKKLGFDtDR-P 575
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