3H0L_P  23 EVVESFYDRYNQteEKVKaYITPLYGKALKQAESLKEREL-------PLFGIPIAVKDNILVEGEKTTCASKILENFVAP 95  Aquifex aeolicus
Q17449  84 EAIRAYFHKAILahEKTN-AVTCFILDAERQAEELDEQAKlpyyvkpPLFGVPLSLKECLKVKGYDTTRGFVQDAYHPAT 162 Caenorhabditis elegans
O00519  95 AVLFTYVGKAWEvnKGTN-CVTSYLADCETQLSQAPRQg--------LLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAE 165 human
O45089  82 ETLRAFQRKAYEstEKTN-CVCFFIQEALEIAENLEHLATdpnyqkpPLFGVPVSIKESIHVKNLDSTAGYAQKINNPSD 160 Caenorhabditis elegans
Q17447  85 DAVRTYYAKAISanEKTN-SVCMFVKEAEKWAMDWDEKAKdpqfqkpPLFGLPMSLKECVPLEGYDQTRGFVQDTFRPTE 163 Caenorhabditis elegans
P22580  79 EITAAFCHRAALihQVVNcLSEIMFSEALRLADYYDSNRPai---lpPLYGIPISLKDQCNVEGVDTSLGYLCRTFKPKT 155 Saccharomyces cerevis...
O59805  76 ELVTAFCKRAAIaqQLVNcVNELFYEEALARAAELDEYYAktgslvgPLHGVPVSVKEHISIKNHTATASFLAKANIIAE 155 Schizosaccharomyces p...
Q12559  74 DVTLAFCKRAALahQLVNcAHDFFPELALAQARELDRYFEthkkpvgPLHGLPISLKDQLRVKGTETCMAYISWLGKRDT 153 Aspergillus oryzae RIB40
P9WQ95  33 DVVEAAIARAEAvnPALNaLAYAAFDVARDAAAMGTGQEA-------FFSGVPTFIKDNVDVAGQPSMHGTDAWEPYAAV 105 Mycobacterium tubercu...
O28325  20 ELVEECLEKIERlnPKIN-AFVTLNEKAIEEAKKADVST--------PLAGLPIAIKDNVETRGIRTTYCSKFYENYVPE 90  Archaeoglobus fulgidu...

3H0L_P  96 Y--DATVIERLKKAGALIVGKTNLDEFAMGSSTEYSAFFPTKNPWDLERVPGGSSGGSAASVAVLSAPVSLGSDTGGSIR 173 Aquifex aeolicus
Q17449 163 E--DSIQVEHYKKLGLIPFCQTNVPQSLLSYNCSNPLFGTTTNPYDSTRTCGGSSGGEGALIGAGGSLIGIGTDVGGSVR 240 Caenorhabditis elegans
O00519 166 C--DSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIR 243 human
O45089 161 A--NSVSVDQLIRLGAVPFVHTNIPIALLSYGCSNGVYGTTLNPLDNSRVPGGSSGGEAALVSLGGSVLGIGTDVGGSIR 238 Caenorhabditis elegans
Q17447 164 T--DGVLVQQLKKLGAIPYVQTNVPQSLLSYNCSNPVYGTTNHPMDKTRTSGGSSGGESALISADGSLLGIGGDVGGSIR 241 Caenorhabditis elegans
P22580 156 KneESLIVSFLRDLGAIIFVKTTVPSSMMATDTQSNTFGYTYNSINLSFSSGGSSGGEGSLIGAHGSLLGLGTDIGGSIR 235 Saccharomyces cerevis...
O59805 156 K--DSDLVATVRKAGAVFYCRTPQPQAIMHLETSSNLTGVTVNPFNRKLTPGGSSGGEGALLGIKASVLGIGSDIGGSIR 233 Schizosaccharomyces p...
Q12559 154 S--DSILTALLRKAGAVFLVKTSVPQTLMVCETVNNIIGRTSNPRNLNLSCGGSSGGEGAMIAMRGGAIGIGTDIGGSIR 231 Aspergillus oryzae RIB40
P9WQ95 106 A--DSEITRVVLGTGLVSLGKTQLSEFGFSAVAEHPRLGPVRNPWNTDYTAGASSSGSGALVAAGVVPIAHANDGGGSIR 183 Mycobacterium tubercu...
O28325  91 E--DAVLVERLKKAGAVIIGKTNMPEFGLIAYTDNPMFGPTRNPWDLSRTVGGSSGGSAAAVAAGILPVASGNDGGGSIR 168 Archaeoglobus fulgidu...

3H0L_P 174 QPASFCGVIGIKPTYGRVSRYGLV----AFASSLDQIGVFGRRTEDVALVLEVISGWDEKDSTSAKVpvpe-----wsee 244 Aquifex aeolicus
Q17449 241 IPCHFTGTAGIKPSKMRFAHRGGGasvpGKPLIDANDGPMAKDVKTNVEFLRNVWGDIDFQSDRDPYcppvh----wnes 316 Caenorhabditis elegans
O00519 244 FPSSFCGICGLKPTGNRLSKSGLKgcvyGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPplpf------ree 317 human
O45089 239 TPASFCGLAGFKSSSDRSPQLGKTasipGRQLLLSVEGPIAKNIDVCVEYLRLKW-NDPLLYKKDVYmppvk----fqen 313 Caenorhabditis elegans
Q17447 242 IPCAYTGTTGIKPSHLRFSHRGVCgsvpGRPLINSNDGPMSTRVETNVDFLRTVWADT-WITEQDPYvppvt----wnee 316 Caenorhabditis elegans
P22580 236 IPSSYQGLFGLKPTFGRVPYLRVDnsfeGRETIPSVIGPLARDLSDLRYFMSCVINICQPWVQDVKcipyh-----fdss 310 Saccharomyces cerevis...
O59805 234 SPAANNGLFGLRPSTLRLSRKGCQgavsGQETILGVVGPLGRSVRDMNLFMKACIDSQPWLDDASLLpmp--------wr 305 Schizosaccharomyces p...
Q12559 232 VPAAFNSLYGIRPSHGRLPYGGMTnsmeGQETIHSVVGPIAHSAQDVRLFLQSVLKEEPWKYDSKVIplpwreaeenaaq 311 Aspergillus oryzae RIB40
P9WQ95 184 IPAACNGLVGLKPSRGRLPLEPEYr---RLPVGIVANGVLTRTVRDTAAFYREAERLWRN--HQLPpvgd------vtsp 252 Mycobacterium tubercu...
O28325 169 IPASFCGLYGLKPSFGRVPCYPSL----PIFIGLHSEGFLTRYVEDTALMLDLVKGWDIRDVKSLPdeefs-----ylka 239 Archaeoglobus fulgidu...

3H0L_P 245 VKKEVKGLKIGLPKEFFeyelQPQVKEAFEnFIKELEKEG-FEIKEVS-LPHVKYSIP-TYYIIAPSEASSNLARYDGVr 321 Aquifex aeolicus
Q17449 317 VYSSEKKLRVGYYIDDGwftpTPALQRAVLeSKKHLEAAG-HTVIPFY-PPRLPSVMQ-LYFRAVCLDGGQYVLNKLLKd 393 Caenorhabditis elegans
O00519 318 VYTSSQPLRVGYYETDNytmpSPAMRRAVLeTKQSLEAAG-HTLVPFL-PSNIPHALEtLSTGGLFSDGGHTFLQNFKGd 395 human
O45089 314 LYNSEKPLKIGYYTFDGyqtaSPAYQRAVReTVAVLKELG-HELVPFE-VPQPDHMYS-IFCAGATADGGLYLMDSLANd 390 Caenorhabditis elegans
Q17447 317 AYKSDKKLKIGYYVDDGwftpTPVCQRAVMeAKQILEDSG-HTLVPFR-PPRVPEVLR-MFLRAVCVDAGTFLSKKLMNd 393 Caenorhabditis elegans
P22580 311 TSKLHDNYVVGIWYGDGvidpPPSDIRALKtCEDLVNKTKgMKAVKWE-PSSELSRELfDLANEADVADSGN-------- 381 Saccharomyces cerevis...
O59805 306 SVAPPKTLKVGIMRSDNvvnpQPPVARAMQmAIDQLSKNPdFDLVDVE-PLDHKYSWD-LISEMYWLDGG---------- 373 Schizosaccharomyces p...
Q12559 312 AKIAEKSLNFAFYDFDGvvrpHPPITRGVEiVRSTLEKDG-HTVAPWT-PYKHAFAVD-LANKIYAADGS-TDVYKHINa 387 Aspergillus oryzae RIB40
P9WQ95 253 VKQR---LRIAVVTRSVlreaSPEVRQLTLkLAGLLEELG-HRVEHVDhPPAPASFVDdFVLYWGFLALAQVRS------ 322 Mycobacterium tubercu...
O28325 240 IEEHPDGVRIAFSPDLGyaivDPEVEEKVReAAFKLEKFGeVEEVKLS-LPNLEQELVtKVVLEVVTFIG---------- 308 Archaeoglobus fulgidu...

3H0L_P 322 yg--yrAKEYKDIFEMYARTRDEGFGPEVKRRIMLGTFALSAGYYDAY-YLKAQKVRR-LITNDFLKAFEE---VDVIAS 394 Aquifex aeolicus
Q17449 394 ii--epTIRFQVTLWMVPVWIQRILSYPVSLVFPRMGMLMQSLTRDTFeLREAYADIE-AYREEFVGLMMKd-nLDVILC 469 Caenorhabditis elegans
O00519 396 fv--dpCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAgKLWELQHEIeVYRKTVIAQWRAl-dLDVVLT 472 human
O45089 391 iippeaDIGFPV--AKLPHFIQRLLRKYWHHRRERQIIQELPHDTEEM-RQMHEKIED--YRHEFVLAMRAk-kLDALVC 464 Caenorhabditis elegans
Q17447 394 ii--dpLLYTQVVLWMVPVPIQRFLSSIIKVFFPRLGNLMDAMTLSTVeLRNTYADIE-AYRSEMAGLMVDq-kIDALLC 469 Caenorhabditis elegans
P22580 382 ------------EIKNEFEISGEPLLDILKPMVLENGRPPYTVN--EWwDLTKRVYNAqQLMRDYYLSFPEserPDVIIS 447 Saccharomyces cerevis...
O59805 374 -----------KVYYDLFNKVGEPILPLTEWIMHQPNVKPHDITa----VWKLTAARD-EYRNRYLKHLQAy-gVDVLLT 436 Schizosaccharomyces p...
Q12559 388 s---gePAIPNIKDLMNPNLPKADLNEVWDAQLQKWR------------YQCEYLDKW-REWEERTGK--E---LDAIIA 446 Aspergillus oryzae RIB40
P9WQ95 323 ------------GRRTFGRTFDPTRLDELTLGLARHTGRNLHR------LPLAIMRLR-MLRRRSVRFFGT---YDVLLT 380 Mycobacterium tubercu...
O28325 309 --------------DRMAEWEKVAFPPYLGFMALAQSLTFRE-------YIKIEERKM-ELWKALRGIFEE---YDYLIT 363 Archaeoglobus fulgidu...

3H0L_P 395 PTTPTLPFKFGERLe-----nPIEMYLSDILT---VPANLAGLPAIS------IPIAWK-D------------------G 441 Aquifex aeolicus
Q17449 470 PASIMPAPQHDIPSkvvsgvsYTCLYNLLDFGagvVPVTAVSKSDEE------KLINEYpEtdkwyqit--kkatlgavG 541 Caenorhabditis elegans
O00519 473 P-MLAPALDLNAPGratgavsYTMLYNCLDFPagvVPVTTVTAEDEAqmehyrGYFGDIwDkmlqkg-------mkksvG 544 human
O45089 465 PAFGCPPPHHGMPNkilgansYPALYNLIDFAagtVPVTVQKQEDEVe-----LRKMKT-Edswdrrvv---tesknciG 535 Caenorhabditis elegans
Q17447 470 PVTVSPALPHVSPSklfagtsYTGIFNLLDYAagsVNVTHVTKQDE-------LDLEDYeEsdpwyala--kkgsrgtiG 540 Caenorhabditis elegans
P22580 448 P-TTLMPFRPGDMLktt--lrYILLFNVLNFPslsIPVGSVDCQIDGlm---dTTSALNpEdkmiktywndliqsgeidG 521 Saccharomyces cerevis...
O59805 437 PVGPSPAPKLGEAKyw----tYTSVWNLLDLPavvFPVTTVDPKLDVkde-syIPMNEQdAanyety------spedylD 505 Schizosaccharomyces p...
Q12559 447 PVAATAAVRHNQFRyy----gYATVFNVLDYTsvvVPVTYADKAVDH------RLADYQpVsdmdkavya-eydpevyhG 515 Aspergillus oryzae RIB40
P9WQ95 381 PTVAEATPQVGYLApt---dyQTVLDRLSSWVvftPVQNVTGVPAIS------LPLAQS-Ad-----------------G 433 Mycobacterium tubercu...
O28325 364 PTVACKPFEIGKLGpeeiagkAITPIGWMPFT---YPFNFTGQPAAS------IPAGFS-Ke-----------------G 416 Archaeoglobus fulgidu...

3H0L_P 442 LPVGGQLIGKHWDETTLL 459 Aquifex aeolicus
Q17449 542 MPIGVQVAAPPYREEAVL 559 Caenorhabditis elegans
O00519 545 LPVAVQCVALPWQEELCL 562 human
O45089 536 LPVSVQIATPPYREEMCL 553 Caenorhabditis elegans
Q17447 541 FPIGVQVATPPYKEETCL 558 Caenorhabditis elegans
P22580 522 FPIGLQVVSPTFNDNEVC 539 Saccharomyces cerevisiae S288C
O59805 506 APVSLQLVGKRWQDEELL 523 Schizosaccharomyces pombe 972h-
Q12559 516 APVAVQIIGRRLSEERTL 533 Aspergillus oryzae RIB40
P9WQ95 434 MPVGMMLSADTGREALLL 451 Mycobacterium tuberculosis H37Rv
O28325 417 LPIGMQIVGKPYDDVGVL 434 Archaeoglobus fulgidus DSM 4304