2FWM


Conserved Protein Domain Family
dhbA_paeA

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TIGR04316: dhbA_paeA 
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2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
Members of this family are 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (EC 1.3.1.28), the third enzyme in the biosynthesis of 2,3-dihydroxybenzoic acid (DHB) from chorismate. The first two enzymes are isochorismate synthase (EC 5.4.4.2) and isochorismatase (EC 3.3.2.1). Synthesis is often followed by adenylation by the enzyme DHBA-AMP ligase (EC 2.7.7.58) to activate (DHB) for a non-ribosomal peptide synthetase.
Statistics
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PSSM-Id: 275120
Aligned: 20 rows
Threshold Bit Score: 355.056
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2FWM_X        10 VWVTGAGKGIGYATALAFVEAGAKVTGFDQAFTQEQ-----------YPFATEVMDVADAaQVAQVCQRLLAETeRLDAL 78  Escherichia coli
ZP_05883089    8 VLLTGSSQGIGYAVLERLLIEGYRVVATDRCIDKLDehlaslqrqyaDQLDCYAIDLLDS-QLDQKVAQLCRQY-RFDHL 85  Vibrio metschni...
WP_011092101  17 VWVTGAASGIGESIARQFVALGANVIGFDRAFQHNAspy------ndRPFRCVTLDISEPnSVATVCRQQLAETg-LDVL 89  Pectobacterium ...
WP_012777082  12 VWITGAGSGIGYQTAYRFQQAGAKVIGFDITFPEGd-----------LPFTPYLLDISDTiAVSRCCEQLLVQQpRLDVL 80  Photorhabdus as...
WP_015854748  12 VWVTGAGQGIGYATACAFYRAGSTVTGIDKTFHPNTn----------YPFAIHQADVADSkQVKEVVQVLLNTTpQLDVL 81  Dickeya
CDQ49810       7 VLLTGAGQGIGYAVLGSLLASGYRVVATDKNHHQLTqqlaslnarytEQLHCYELDLQHHdDVKKRVQELNERY-QFDHF 85  Vibrio anguillarum
WP_012146131  12 VWVTGAGAGIGLATALAFVQAGAEVIGFDKHFGEPe-----------YAFRTEVLDIADSdAVDRVCGRLLAEQgALDVL 80  Serratia
WP_015818365  15 VWITGAGRGIGYAIAESFYRAGAQVTGLDCAFPQHe-----------YPFATVKCDLCKPeEIRACCQRLFVENgQIDVL 83  Teredinibacter ...
AAB40796      18 VWVTGAGKGIGYATALAFVEAGAKVTGFDQAFTQEQ-----------YPFATEVMDVADAaQVAQVCQRLLAETeRLDAL 86  Escherichia coli
WP_012236513   8 ALVTGAAQGIGEAVARRLAARGAAVAAVDANRERLAavvad-lqasgHRAAAFAVDVADGeAVDGAVERIERELgPLEML 86  Sorangium cellu...
2FWM_X        79 VNAAGILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQTMNQFRRQRGGAIVTVASDAAHTPRIGMSAYGASKAALKSLAL 158 Escherichia coli
ZP_05883089   86 VSCAGILSIGSVSSMPIEEIRKMFEVNTFAAMSIIQNVAKGMKQRKSGNIVVIGSNSANTPRMNIGGYAASKSALHLLVK 165 Vibrio metschni...
WP_011092101  90 VNAAGILRLGDIDALSVDDWYQCINVNASGAFYLLNALVPHFKQQRRGAIVCVGSNAAHVPRVQMAAYCASKAALTSLSH 169 Pectobacterium ...
WP_012777082  81 VNGAGILRLGATEEITFEDWQQCLSVNAGGAFNLFQATIPQFQRQKAGAIVTIASNAAHVPRVGMSAYCASKAALRSLCL 160 Photorhabdus as...
WP_015854748  82 VNAAGILRTGQTDEIDPQDWQLCFNVNAGGAFNMFQHTMSVFRRQRAGAMVTVSSNAAHVPRLGMSAYGASKAALRSLCH 161 Dickeya
CDQ49810      86 ISCAGILHLGSITELSMSEIKAMFDVNTFGTLAALQGVAIGMKARQRGNVIVIGSNSANTPRLNIGAYAASKSALHMLVK 165 Vibrio anguillarum
WP_012146131  81 VNGAGILRMGLADETSTADWLACLAVNAGGAFNMFRHALPVFRRQRRGAIVSVASNAAHVPRVGMAAYCASKAALRSLCN 160 Serratia
WP_015818365  84 VNAAGILRFAEITELTEDDWQASLDVNVSAVFHLIQQCIPRFKQQKSGVIVNIASNAARVPRMGMAAYCASKAALESFSH 163 Teredinibacter ...
AAB40796      87 VNAAGILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQTMNQFRRQRGGAIVTVASDAAHTPRIGMSAYGASKAALKSLAL 166 Escherichia coli
WP_012236513  87 VNVAGVLRVGGALSLTSDDWERTFAVNTRGVFNVSRAVARRMVPRRSGSIVTVGSNAARTPRMNMGAYAASKAAAAQWTK 166 Sorangium cellu...
2FWM_X       159 SVGLELAGSGVRCNVVSPGSTDTDMQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHITLQ 238 Escherichia coli
ZP_05883089  166 CCALELAEFGIRCNIVSPGSTRTEMQTQLWNESYGEQQVIEGNLAQYRLGIPLGRMAEPADIANTVLFLMSDSARQITMH 245 Vibrio metschni...
WP_011092101 170 CAGLELAPYGVRCNLVSPGSTDTPMQRGMWHSADAEQRTIAGFPDQYKLGIPLGKIAQPEEIANTVVFLASDLASHITMQ 249 Pectobacterium ...
WP_012777082 161 SVGLELAPYGVRCNLVSPGSTDTPMQRDMWQTEASKQQVIQGFSELFKLGIPLGKIATPTEIADAILFMASDLASHITLQ 240 Photorhabdus as...
WP_015854748 162 TVALEMAPFGVRCNLVSPGSTDTEMQRSLWHTPDAEAQTIKGFPEQYKLGIPLQKIAHPQEIAATILFLASDAASHLVMQ 241 Dickeya
CDQ49810     166 CAALELANDGIRCNIVSPGSTRTEMQTQLWNSEYGEREVIKGNLEQYRLGIPLGKMAEPEDIAGVVMFLMSNAASQITMH 245 Vibrio anguillarum
WP_012146131 161 TVGLEMAPYGVRCNLVSPGSTNTPMQRGMWQDETGEQNTINGFPEQFKLGIPLGKIAQPQEIADAILFLASDRASHITMQ 240 Serratia
WP_015818365 164 CIALELAAYGVRCNLVSPGSTNTPMLQNMLSNDAGFERTIQGSLATFKNGIPLRKIAHPNDIANSVLFLASDLASHITLH 243 Teredinibacter ...
AAB40796     167 SVGLELAGSGVRCNVVSPGSTDTDMQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHITLQ 246 Escherichia coli
WP_012236513 167 CLGLELAQHDIRCNVVSPGSTDTPMQRALWADDRGAQAVIAGAPEAFRLGIPLRRIATTDDVASAVLFLLSDEARHITMH 246 Sorangium cellu...
2FWM_X       239 DIVVDGGSTLG 249 Escherichia coli
ZP_05883089  246 DLRVDGGATLD 256 Vibrio metschnikovii CIP 69.14
WP_011092101 250 DVVVDGGATLt 260 Pectobacterium atrosepticum
WP_012777082 241 DIVIDGGATLG 251 Photorhabdus asymbiotica
WP_015854748 242 DIVIDGGAVLN 252 Dickeya
CDQ49810     246 DLRVDGGATLD 256 Vibrio anguillarum
WP_012146131 241 DIVIDGGATLa 251 Serratia
WP_015818365 244 NLVVDGGATLS 254 Teredinibacter turnerae
AAB40796     247 DIVVDGGSTLG 257 Escherichia coli
WP_012236513 247 DLCVDGGATLG 257 Sorangium cellulosum
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