Conserved Protein Domain Family
quinone_pig3

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TIGR02824: quinone_pig3 
putative NAD(P)H quinone oxidoreductase, PIG3 family
Members of this family are putative quinone oxidoreductases that belong to the broader superfamily (modeled by Pfam pfam00107) of zinc-dependent alcohol (of medium chain length) dehydrogenases and quinone oxiooreductases. The alignment shows no motif of conserved Cys residues as are found in zinc-binding members of the superfamily, and members are likely to be quinone oxidoreductases instead. A member of this family in Homo sapiens, PIG3, is induced by p53 but is otherwise uncharacterized. [Unknown function, Enzymes of unknown specificity]
Statistics
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PSSM-Id: 274316
Aligned: 20 rows
Threshold Bit Score: 455.952
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
BAD55064        1 MRAIELNgf-gGPEVLVWGKAADPVPGHGEVLIDVVAAGVNRADLLQRQGNYPPPAGASDILGLECSGVVAEVG-EGVRe 78  Nocardia farci...
CAD95992        4 MRAVVAE----SSDRLVWQEVPDVSAGPGEVLIKVAASGVNRADVLQAAGKYPPPPGVSDIIGLEVSGIVAAVG-PGVTe 78  Mycobacterium ...
BAC16990        1 MKAIVQTee-kNTASLELQDVPVPTLKPGEVLVEVKAAGVNRADLLQTQGNYPVPPGASEILGLECAGIIADPG-DTGR- 77  Corynebacteriu...
AAG04526        1 MTAIEIArp-gGPEVLVATSRPLPTPGPREVLVEVRAAGVNGPDVLQRKGVYDPPPGASDIPGLEIAGTVRAVGsEVSR- 78  Pseudomonas ae...
CAE14635       12 MLAISIIkp-gGPEKLHLVQVPLPRPGKGYLLVKVAAAGVNRPDIFQRMGSYPPPPDASPLPGLEIAGEVVAKGeGCER- 89  Photorhabdus l...
AAN53718        8 YAHIHIEqp-gAPEVMQLSRSSLPVVGAGQVLIRVSAAGVNGPDLKQRAGAYPPPPGASLILGLEVAGEICALGeGVTQ- 85  Shewanella one...
AAL54118       16 VLSVIATrp-gGPEVLELVPRELPALKRGEMRVRIHAAGVNRPDAMQRAGQYPPPPGVTDVLGLELSGVVLEIAeDVTR- 93  Brucella melit...
chgcsh:XC3493   6 MTAIAIRngkgDADALHAVEQARPQPAPGQVLIRVHAAGINRPDLLQRGGHYPPPPGAPETLGLEVAGEVVVAAg---R- 81  Xanthomonas ca...
AAY93648        1 MKALQGVe-----GHVEWVEEPSPACDVGQVRIRVAAAGLNRADLLQRAGLYPPPPGASKALGLECSGVVSEVGpGSSW- 74  Pseudomonas pr...
CAI86383        1 MKYISHEd----G-ILAFSETNKPVLKSHEVLVKVAAIGVNRADCMQRQGKYPAPKDDSQILGLECAGIVCDIGgKVDKi 75  Pseudoalteromo...
BAD55064       79 WQVGDRVCALLSGGGYAERVVVPATQVLPVPEGMDLAAAAGLPEVAATVWSNLVMTAGLHAGQLVLIHGGGSGIGTHAIQ 158 Nocardia farci...
CAD95992       79 WSAGQEVCALLAGGGYAEYVAVPADQVLPIPPSVNLVDSAALPEVACTVWSNLVMTAHLRPGQLVLIHGGASGIGSHAIQ 158 Mycobacterium ...
BAC16990       78 -SKGEEVACLLTGGGYAEFVAVPEGQLMPIPEGFSFVEAASIVEVACTVWSNIGMLAGLKEGQTFLVHGGAGGIGTFAVQ 156 Corynebacteriu...
AAG04526       79 FAVGEAVMALIPGGGYAQFAVADERTTLHLPDGLGMEEAAALPETFMTVWVNLFQRGGFKAGETLLVHGGASGIGTAATM 158 Pseudomonas ae...
CAE14635       90 WNLGDKVCALVAGGGYAEYCLVHDSVALPIY-GLDFVQAAALPENFFTVWANVFQTGQLKPGENLLIHGGTSGIGSVTIM 168 Photorhabdus l...
AAN53718       86 WQLGDKVCALVPGGGYGEYTLTYAAHCLPIPKGFSMVQAAALPETFFTVWGNLFMRAGLKAGETVLIHGGSGGIGSTAIA 165 Shewanella one...
AAL54118       94 FGPGDRIMALVAGGAYSEEAIVQADVCIPVPAGLSMVEAAGIPETYFTVWSNLFQRAGLQPGETVLLHGGTSGIGVTATL 173 Brucella melit...
chgcsh:XC3493  82 WKVGDRVCALLGGGGYAQYAAVDARHVLPVPEGMTLVQAAALPETIFTAYANLFEHGRLAAGEWLLLHGATSGIGVTAIQ 161 Xanthomonas ca...
AAY93648       75 -QVGDRVCALLAGGGMAEEVVVDARHVLPVPEGLSLAEAAALPEVYSTAWLNLFQLAALKPGEKVLLHAGASGVGSAAIQ 153 Pseudomonas pr...
CAI86383       76 wl-nkRVFALCAGGAYSEYVAVDAKQLMELPDDVSMREGAAISEVYLTAFGALFELGKLQAGQTALIHAGASGVGGAAIQ 154 Pseudoalteromo...
BAD55064      159 VARQRG-ARVAVTAGSAEKLErCRE-LGADVLINYREQDFVEVVRAQESGagaaGADIILDNMGAAYLGRNVAALAPHGH 236 Nocardia farci...
CAD95992      159 VARALA-ARVAITAGSPEKLElCRD-LGAQITINYRDEDFVARLKQETDGs---GADIILDIMGASYLDRNIDALATDGQ 233 Mycobacterium ...
BAC16990      157 MGKAMG-ATVAVTTGSPEKLQtCQQ-LGADILINYREEDFAEVLKNR--------ADVILDIIGAKYLGQNVKALAKDGH 226 Corynebacteriu...
AAG04526      159 LGKAFGaAKIFTTISSEAQRE-ASLrLGADVAIDYTEQDFVEEVLRGTEGr---GVDVIVDIVAGDYVTRNYQAAAMNGR 234 Pseudomonas ae...
CAE14635      169 LAKAFG-AKVITTVGSDEKAK-VAHsLGADFVINYHKEDFVDRVLKITGNh---GVDMVVDLIGGDYVNKNYKVAAKFGR 243 Photorhabdus l...
AAN53718      166 LANRLG-AKVIATTGQDEKRD-YCLgLGADLVVNYNSQNFVEEVMSFTQGk---GVNVVFDIAGGDFINLNLQSLALDGR 240 Shewanella one...
AAL54118      174 LAKAIG-ARMITTCGSDDKCR-ASEaLGAIASINYRTTDFVEAGRALTEGr---GPEVVIDMVGGSYMQRNLQLVAEDGR 248 Brucella melit...
chgcsh:XC3493 162 LAKAAG-AHVLATARSAGKAA-QAReLGADVAIDSTTESFVAAAK---AHa---GVDVALDMVGASVFADTLEALNPGGR 233 Xanthomonas ca...
AAY93648      154 LCKAFG-NPCWVSVGSADRLA-YCEsLGAQGGVVRTDG--IEALRDFGP------FDVILDPVGANYVANNLKLLALDGR 223 Pseudomonas pr...
CAI86383      155 MAKSAG-ATVVITAGSDEKCA-HAKaLGADHAINYKTTDFVEYMKANNLT-----ANTIVDPVSGSYLNKNAAVAAMDCQ 227 Pseudoalteromo...
BAD55064      237 LVIIGMQGGVTGELNVGALLGKWGSVHATNVRNRPAtgtGSKAEIIAEVRRHLWPLVADGAVVPVIHAEFDIADAAQAHR 316 Nocardia farci...
CAD95992      234 LIVIGMQGGVKAELNLGKLLTKRARVIGTTLRARPVsgpHGKAAIAQAVAASVWPMIAANRVRPVIGTRLPIQQAAQAHE 313 Mycobacterium ...
BAC16990      227 MVTIGLQGGVKGELNLGLLLAKRGTISATALRGRDD---ADKARIVAATVEAIWPMLADGRITPHIDHTLPLADAAKALK 303 Corynebacteriu...
AAG04526      235 IVQIGVIKGKAAEVDLFPMLSKRLVHLGSTLRSRSH---DEKGAIIAELERQVWPHVRAGTVRPQVFRTFPLEQARQAHE 311 Pseudomonas ae...
CAE14635      244 IIQIGMMKGNPENLNLMPLMLKRLTHTGSTLRSRSV---EEKAEIAKELEKQVWPLLKSGKVTPLICKVFDLKDAADAHR 320 Photorhabdus l...
AAN53718      241 MVSVSTQRSPKAEVNILQLMAKRIVWTGSTLRPQTV---EAKAEIARQLRERVWPLLDSQQIVPHIFATYPLIDAPKAHR 317 Shewanella one...
AAL54118      249 IAQIAFQQGSEAQMDMGPLLFKRLTLTGSTLRARPL---VMKAALARSVEAEVLPLVLNKGARPVIDSVFDLADVQAAHA 325 Brucella melit...
chgcsh:XC3493 234 IVYIASQAGATLEVPIPLLMRKQAIITGSTLRPRNA---DEKARLAAEVERVVWPWIAQGKVRVLIDQCFPLAEAAAAHR 310 Xanthomonas ca...
AAY93648      224 WVLIGLMGGREAQLDLAQVLAKRIQFLGSTLRSRND---QFKADLLSDLGQNVWPLFSEGRLSPQLARTFAIQDAEAAFA 300 Pseudomonas pr...
CAI86383      228 IVMLAFLDGRFAEVDFARLLQKRISFHASTLRNRSI---EFKRALRDDFVARFYSDIASKSYNFNLYKVLPWSQASEAHA 304 Pseudoalteromo...
BAD55064      317 VLDSSRAFGKVVLRV 331 Nocardia farcinica IFM 10152
CAD95992      314 LMLSGKTFGKILLTV 328 Mycobacterium bovis AF2122/97
BAC16990      304 ALEDGTVTGKLVLEV 318 Corynebacterium efficiens YS-314
AAG04526      312 LMDSGQHIGKIVLTS 326 Pseudomonas aeruginosa PAO1
CAE14635      321 MMEAGDVIGKVMLVN 335 Photorhabdus luminescens subsp. laumondii TTO1
AAN53718      318 LMQSGEHRGKVVLTL 332 Shewanella oneidensis MR-1
AAL54118      326 HLEASAHTGKIILKT 340 Brucella melitensis bv. 1 str. 16M
chgcsh:XC3493 311 YLEQGSHLGKVVLEM 325 Xanthomonas campestris pv. campestris str. 8004
AAY93648      301 ELATNQVSGKLVLVI 315 Pseudomonas protegens Pf-5
CAI86383      305 ILERNENAGKVVLSV 319 Pseudoalteromonas haloplanktis TAC125
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