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History Report on CCDS ID 4137  | Interpretation | Date | Source | Comment | Data |
|---|
| CCDS: Made public |
03/02/2005 |
NCBI |
|
CCDS Release: 1 |
| CCDS: Retained |
02/26/2007 |
NCBI |
|
CCDS Release: 3 |
| CCDS: Retained |
04/30/2008 |
NCBI |
|
CCDS Release: 5 |
| CCDS: Updated |
07/28/2009 |
NCBI |
|
CCDS Release: 6 |
| CCDS: Public note |
01/27/2011 |
NCBI |
The coding region has been updated to extend the N-terminus to an upstream in-frame ATG. The update adds an N-terminal transit peptide, which is necessary for mitochondrial localization, and is consistent with the known gene function in lysine catabolism (which occurs in the mitochondrion). The transcript includes three potential translational start codons, all of which have weak Kozak signals. Ribosomal leaky scanning may result in the use of all three start codons, and a mitochondrial transit peptide can be predicted for the N-terminus arising from use of either the first or second initiation site. The second start codon is represented for this CCDS protein because the predicted transit peptide is scored as more probable, and the second ATG is more strongly conserved. This representation of the mitochondrial isoform is consistent with published reports (see PMIDs: 19885858 and 20207735). |
CCDS version: 4137.1 |
| CCDS: Retained |
03/30/2011 |
NCBI |
|
CCDS Release: 8 |
| CCDS: Retained |
08/11/2011 |
NCBI |
|
CCDS Release: 9 |
| CCDS: Retained |
09/19/2012 |
NCBI |
|
CCDS Release: 11 |
| CCDS: Retained |
03/21/2013 |
NCBI |
|
CCDS Release: 12 |
| CCDS: Retained |
08/30/2013 |
NCBI |
|
CCDS Release: 14 |
| CCDS: Retained |
11/21/2013 |
NCBI |
|
CCDS Release: 15 |
| CCDS: Retained |
06/20/2014 |
NCBI |
|
CCDS Release: 17 |
| CCDS: Retained |
04/03/2015 |
NCBI |
|
CCDS Release: 18 |
| CCDS: Retained |
08/11/2016 |
NCBI |
|
CCDS Release: 20 |
| CCDS: Review status |
10/03/2016 |
NCBI |
|
by RefSeq, Havana and CCDS collaboration |
| CCDS: Retained |
05/16/2018 |
NCBI |
|
CCDS Release: 22 |
| CCDS: Retained |
08/10/2022 |
NCBI |
|
CCDS Release: 24 |
|
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